Prevention of Biomarkers for Vascular Cognitive Impairment
Our Research Group, highly focused on VCI, involves multiple institutions and investigators from across Singapore, led by well-established and productive PIs, seeks to:
Theme 1: undertake a multiple lifestyle interventional study to retard VCI-associated disease progression and to evaluate selected biomarkers for their predictive and surrogate outcome potential.
Theme 2: assess longitudinal changes in brain structure, function and pathology using (MRI, PET, retinal) neuroimaging, as well as novel blood and genetic markers to determine their diagnostic and prognostic value as biomarkers.
Theme 3: to link Themes 1 and 2 with health services research (HSR) on healthcare costs associated with VCI to facilitate clinical and policy decision making. Hence, we shall utilise basic, translational, clinical and implementation science approaches to improve the understanding of basic mechanisms underlying age-related VCI which will improve disease diagnosis, reduce incidence and progression through the development of new therapies and hence enhance quality of life.