Publications
The Department of Ophthalmology has had a proud and long-standing history of excellence in research. Over the years, we have developed major research programmes that have impacted clinical care and improved our patients' eye health.
Our affiliation with the Singapore Eye Research Institute has enables us to continue to participate in world leading research projects. We are proud to share that not only has some of our faculty's research work been published in several renowned international journals – including the New England Journal of Medicine, the Lancet, and Nature Genetics – it has also been presented at top regional and global meetings.
Retina
| Title | Journal |
|---|---|
| Polymeric hydrogels as a vitreous replacement strategy in the eye. Lin Q, Lim JYC, Xue K, Su X, Loh XJ. |
Biomaterials. 2020 Nov 24;268;120547 (IF:10.317) ACS Appl. Bio Mater. 2020, 2, 12,9043-9053 **Stem Cell Reports (Accepted, In Press) (IF:6.032) |
| PCL-based thermogelling polymer: Molecular weight effects on its suitability as a vitreous tamponade. Xue, K., Liu Z, Lin Q., Lim JYC, Tang YTK, Wong SL, Parikh B, Su X*, Loh XJ* |
Translational Vision Science and Technology (Accepted, In Press) |
| Adult stem cell derived human retinal pigment epithelial cell transplantation supports retinal function in non-human primate models. Liu Z, Parikh H, Tan Q.S.W, Wong D.S.L. Ong K.H., Yu W, Seah J.Y, Holder G.E, Hunziker W, Tan G.W.S, Barathi V.A., Lingam G, Stanzel B.V*, Blenkinsop T.A.*, Su.X*. |
Commun Biol. 2020 Dec 11;3(1):755 J Clin Med 2020 Sept 10:9 (9):E2920. |
| Surgical macular dynamics during subretinal injection in non-human primates with intraoperative OCT: Pearls on how to reduce foveal trauma. Tan G.S.W, Liu Z, Ilmarinen T, Barathi V.A. Chee CC, Lingam G, Su.X, Stanzel B.V. |
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| Common variants in SOX-2 and congenital genes contribute to age-related nuclear cataract. Ekaterina Yonova-Doing, W. Zhao, Su.X et al |
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| A Pilot Study on MicroRNA Profile in Tear Fluids to Predict Response to Anti-VEGF Treatments for Diabetic Macular Edema. Chan H.W, Yang B., Wong W.M., Blakeley P., Seah Y.J., Tan Q.S.W., Wang H., Bhargava M., Lin H.A, Chai C.H.C., Mangunkusumo E.A., Thet N., Yuen Y.S., Sethi R., Wang S., Hunziker W., Lingam G., Su X*. |
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| Review: Highlights from the 2019 International Myopia Summit on ‘Controversies in Myopia’. Wong CW, Foo LL, Morjaria P, Morgan I, Mueller A, Davis A, Keys D, He MG, Sankaridurg P, Zhu JF, Hendicott P, Tan D, Saw SM, Cheng CY, Lamoureux E, Crowston J, Cheung C.M.J, Sng C, Chan C, Wong D, Lee SY, Agrawal R, Hoang Q.V., Su X, Koh A, Ngo C, Chen H, Wu P.C, Chia A, Jonas J.B, Wong T.Y, Ang M. |
Br J Ophthalmol 2020 Aug 18; bjophthalmol-2020-316475. |
| Commentary: All India Ophthalmological Society members' survey: Practice pattern of intravitreal anti-vascular endothelial growth factor injection. Lingam G, Su X. |
J Ophthalmol. 020;68(6):1100-1101. |
| Systemic Factors Associated with Treatment Response in Diabetic Macular Edema. Wong W, Chee C, Bhargava M, Chai C, Lin H, Zhao P, Mangunkusumo E.A., Naing T, Yuen Y.S, Wong TY, Su X*, Lingam G*. |
Journal of Ophthalmology 2020:1875860. |
| Re-visiting the dangers of the coronavirus in the ophthalmology practice. Seah Y.J., Su X, Lingam G. |
Eye(Lond) 2020 Jul;34(7):1155. |
| Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases. Seah Y.J., Zhao X.X, Lin Q, Liu Z, Su Z.Z.S, Yuen Y.S, Hunziker W, Gopal Lingam, Loh X.J, Su X*. |
Eye (Lond). 2020 Aug;34(8):1341-1356. |
| A new highly transparent injectable PHA-based thermogelling vitreous substitute. Kun X, Liu Z, Jiang L, Kai D, Li Z, Su X, Loh X.J*. |
Biomat. Sci. 2020 Feb 4;8(3):926-936. |
| Sustained delivery of anti-VEGFs from thermogel depots inhibits angiogenesis without the need for multiple injections. Kun X, Zhao X, Zhang Z, Qiu B, Tan S.W.Q, Ong K.H., Liu Z, Parikh BH, Barathi VH, Yu W, Wang X, Lingam G, Hunziker W, Su X and Loh XJ. |
Biomaterial Sci 2019 Nov 1;7(11):4603-4614. |
| Retinal-detachment repair and vitreous-like body reformation via a thermogelling polymer endotamponade. Liu Z, Liow SS, Lai SL, Alli-Shaik A, Holder GE, Parikh BH, Krishnakumar S, Li Z, Tan MJ, Gunaratne J, Barathi VA, Hunziker W, Lakshminarayanan R, Tan CWT, Chee CK, Zhao P, Lingam G*, Loh XJ*, Su X*. (Featured in News and Views, Nature Biomedical Engineering) |
**Nature Biomed Eng. 2019 Aug;3(8):598-610.(IF: 18.952) |
| Clinical and Genetic Findings in CTNNA1-Associated Macular Pattern Dystrophy. Tanner Alexander; Chan Hwei Wuen; Pulido Jose S; Arno Gavin; Ba-Abbad Rola; Jurkute Neringa; Robson Anthony G; Egan Catherine A; Knight Hannah; Calcagni Antonio; Taylor Rachel L; .Lenassi Eva; .Black Graeme C; Moore Anthony T; Michaelides Michel; Webster Andrew R; Mahroo Omar A. |
Ophthalmology. 2020 Nov. Journal of dietary supplements. 2020 Mar; 34:Pg1939-0211 |
| Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies. Ng Qin Xiang; De Deyn Michelle Lee Zhi Qing; Loke Wayren; Foo Nadine Xinhui; Chan Hwei Wuen; Yeo Wee Song |
Canadian Journal of Ophthalmology, 53(1):49-55 |
| Surgical outcomes and complications of sutured scleral fixated intraocular lenses in pediatric eyes | PLoS ONE; 13(1) |
| Incidence, microbiology, and outcomes of endophthalmitis after 111,876 pars plana vitrectomies at a single, tertiary eye care hospital | Indian Journal of Ophthalmology;66(2):246-251 |
| Clinical features and treatment outcomes of vasoproliferative tumors in Indian participants | PLoS ONE; 13(5) |
| Understanding variable disease severity in X-linked retinoschisis: Does RS1 secretory mechanism determine disease severity? | Ocular Immunology and Inflammation; 27(5):762-765 |
| Diagnostic Challenge with Nocardia Subretinal Abscess: A Case Report from Tuberculosis-Endemic Region | Eye (Basingstoke);33(1):87-96 |
| Retinoblastoma in Asia | Ophthalmic Surgery Lasers and Imaging Retina; 49(10):757-764 |
| Outcome of sutured scleral-fixated intraocular lens in blunt and penetrating trauma in children | Indian Journal of Ophthalmology;66(12)1789 |
| Commentary: Qualitative comparison of choroidal vascularity measurement algorithms | Indian Journal of Ophthalmology66(12)1825-1831 |
| Outcome of vitreoretinal surgery for rhegmatogenous retinal detachment in X-linked juvenile retinoschisis | Canadian Journal of Ophthalmology; 3:253-262 |
| Outcomes of surgery in eyes with familial exudative vitreoretinopathyassociated retinal detachment | EYE; 8:1341-1356 |
| Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases | Eye (Basingstoke); 7:1155-1157 |
| Revisiting the dangers of the coronavirus in the ophthalmology practice | JOURNAL OF OPHTHALMOLOGY |
| Systemic Factors Associated with Treatment Response in Diabetic Macular Edema | EYE; 8:1486-1486 |
| Use of biomaterials for sustained delivery for anti-VEGF to treat retinal diseases (Jan, 10.1038/s41433-020-0770-y, 2020) | EYE |
| Response to 'Comment on: "Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases"' |
Cornea
| Title | Journal |
|---|---|
| Optical and Tectonic Corneal Transplant Outcomes in a Tertiary Hospital in Singapore within the Singapore Corneal Transplant Registry. Ho D, Chai C, Lin H, Htoon HM, Tan AM, Manotosh R, Tan D |
ANNALS ACADEMY OF MEDICINE SINGAPORE, Vol 47(3):92-100 |
| Comparing outcomes of phacoemulsification with femtosecond laser-assisted cataract surgery in patients with fuchs endothelial dystrophy. Wei Wei Dayna Yong; Hui-Chen Charmaine Chai; Liang Shen; Ray Manotosh; Wee Tien Anna Tan |
American Journal of Ophthalmology 2019, Vol 196:173-180 |
| Three-year outcomes of Descemet''s stripping endothelial keratoplasty in eyes with pre-existing glaucoma drainage devices. Hernstadt David Justin; Chai Charmaine; Tan Anna; Manotosh Ray |
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie. 2019 Oct; 54(5):577-584 |
| Disease patterns of microbial keratitis in Singapore: A retrospective case series. Tong Weihan;. Chen David; Chai Charmaine; Tan Anna Marie; Manotosh Ray |
Contact lens & anterior eye : the journal of the British Contact Lens Association. 2019 Aug; 42(4):455-461 |
| Three-year outcomes of Descemet's stripping endothelial keratoplasty in eyes with pre-existing glaucoma drainage devices. Hernstadt DJ, Chai C, Tan A, Manotosh R |
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE; 54(5):577-584 |
Medtech
| Title | Journal |
|---|---|
| The Effect of Patient Education and Telemedicine Reminders on Adherence to Eyedrops for Glaucoma. Yien L; Yanlong W; Chai C; Ching-Chiuan Y; Ho Y; Chuan ET; Pravar Jain; Victor Koh |
Ophthalmology Glaucoma. 2020 May; 3(3):369-376 |
| Novel Automated Approach to Predict the Outcome of Laser Peripheral Iridotomy for Primary Angle Closure Suspect Eyes Using Anterior Segment Optical Coherence Tomography. Koh V, Swamidoss IN, Aquino MCD, Chew PT, Sng C |
Journal of Medical Systems. 2020 42(6); 0148-5598 |
| The Effect of Patient Education and Telemedicine Reminders on Adherence to Eye Drops for Glaucoma. Lai Yien; Wu Yanlong; Chai Charmaine; Yen Ching-Chiuan; Ho Yvonne; Eng Teng Chuan; Jain Pravar; Koh Victor |
Ophthalmology. Glaucoma; 3(5):369-376 Optometry and vision science; 97(8):591-597 |
| A Novel Automated Visual Acuity Test Using a Portable Head-mounted Display. Ong Sze Chuan; Pek Li Cheng Ivy; Chiang Tsuey Ling Carol; Soon Hock Wei; Chua Kuang Chua; Sassmann Chanakarn; Razali Muhammad Azri Bin; Koh Teck Chang Victor |
Journal of Glaucoma.2020; 27(8):1057-0829 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2020 256(2):237-245 |
Glaucoma
| Title | Journal |
|---|---|
| Outcomes and Complications of Ahmed Tube Implantation in Asian Eyes. Choo JQH, Chen ZD, Koh V, Liang S, Aquino CM, Sng C, Chew P |
BRITISH JOURNAL OF OPHTHALMOLOGY, 2020;102(10):1315-1316 |
| Optical coherence tomography angiography: a review of current and future clinical applications. Ang M, Tan ACS, Cheung CMG, Keane PA, Dolz-Marco R, Sng CCA, Schmetterer L |
Acta Ophthalmologica; 1755-375X |
| Minimally invasive glaucoma surgery - coming of age. Sng CCA, Barton K |
Clinical and Experimental Ophthalmology |
| Predicting the outcome of laser perpiheral iridotomy for primary angle closure suspect eyes using anterior segment optical coherence tomography. Sng CCA |
Current Opinion in Ophthalmology; 1040-8738 |
| Descemet membrane endothelial keratoplasty developing spontaneous 'malignant glaucoma' secondary to gas misdirection. Sng CCA |
Graefe's Archive for Clinical and Experimental Ophthalmology; 257(5):983-996 |
| Myopic optic disc changes and its role in glaucoma. Sng CCA |
ADVANCES IN THERAPY, 36(4):976-986 |
| Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma. Reitsamer H, Sng C, Vera V, Lenzhofer M, Barton K, Stalmans I, Ansari E, Au L, Dick HB, Cadarso L, Fea A, Hengerer F, Höh H, Lavin-Dapena C, Lim KS, Marchini G, Masood I, Mossböck G, Nagar M, Nardi M, Rękas M, Shaarawy T, Teus M, Vass C |
British Journal of Ophthalmology, 103(10):1347-1355 |
| Case Series of Combined iStent Implantation and Phacoemulsification in Eyes with Primary Angle Closure Disease: One-Year Outcomes. Hernstadt DJ, Cheng J, Htoon HM, Sangtam T, Thomas A, Sng CCA |
Eye (Basingstoke) |
| Glaucoma in myopia: Diagnostic dilemmas. Tan NYQ, Sng CCA, Jonas JB, Wong TY, Jansonius NM, Ang M |
ADVANCES IN THERAPY |
| Selective laser trabeculoplasty as the primary treatment for open angle glaucoma: time for change? Ang M, Tham CC, Sng CCA |
Scientific Reports |
| Case Series of Combined XEN Implantation and Phacoemulsification in Chinese Eyes: One-Year Outcomes. Sng CCA, Chew PTK, Htoon HM, Lun K, Jeyabal P, Ang M |
Br J Ophthalmol |
| Transscleral cyclophotocoagulation and its histological effects on the conjunctiva | Br J Ophthalmol |
| Anterior segment optical coherence tomography angiography for iris vasculature in pigmented eyes. Ang M, Devarajan K, Tan AC, Ke M, Tan B, Teo K, Sng CCA, Ting DS, Schmetterer L |
CURRENT OPINION IN OPHTHALMOLOGY;2:91-100 |
| Highlights from the 2019 International Myopia Summit on 'controversies in myopia'. Wong CW, Foo LL, Morjaria P, Morgan I, Mueller A, Davis A, Keys D, He M, Sankaridurg P, Zhu JF, Hendicott P, Tan D, Saw S-M, Cheng CY, Lamoureux EL, Crowston JG, Gemmy Cheung CM, Sng C, Chan C, Wong D, Lee SY, Agrawal R, Hoang QV, Su X, Koh A, Ngo C, Chen H, Wu PC, Chia A, Jonas JB, Wong TY, Ang M |
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY; 4:450-461 |
| Glaucoma screening: where are we and where do we need to go? Tan NYQ, Friedman DS, Stalmans I, Ahmed IIK, Sng CCA |
Journal of Glaucoma, 8:648-655 |
| Phacoemulsification vs phacoemulsification with micro-bypass stent implantation in primary angle closure and primary angle closure glaucoma: A randomized single-masked clinical study. Chen DZ, Sng CCA, Sangtam T, Thomas A, Shen L, Huang PK, Cheng J |
Ophthalmology. Glaucoma; 5:350-359 |
| Association between Structure-function Characteristics and Visual Field Outcomes in Glaucoma Subjects with Intraocular Pressure Reduction after Trabeculectomy. Kadziauskiene A, Chua J, Baskaran M, Yow AP, Tan B, Sng C, Ašoklis R, Lesinskas E, Crowston J, Schmetterer L, Wong DWK |
Journal of Glaucoma |
| Treatment Outcomes Using the PAUL Glaucoma Implant to Control Intraocular Pressure in Eyes with Refractory Glaucoma. Koh V, Chew P, Triolo G, Lim KS, Barton K |
Invest Ophthalmol Vis Sci |
| Clinical Efficacy and Safety Outcomes of Micropulse Trans-Scleral Diode Cyclophotocoagulation in Patients with Advanced Glaucoma. Lim JYE, Cecilia AM, Lim KAD, Sng C, Loon SC, Lun WXK, Chew TKP, Koh TCV |
Journal of Glaucoma, 27(8):1057-0829 |
| Focal Structure-Function Relationships in Primary Open-Angle glaucoma using OCT and OCT-A measurements | Ophthalmology; 10:1427-1429 |
| Outcomes and Complications of Ahmed Tube Implantation in Asian Eyes. Choo JQH, Chen ZD, Koh V, Liang S, Aquino CM, Sng C, Chew P |
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.); 4:285-290 Current opinion in ophthalmology; 5:374-379 Ophthalmology |
Others
| Title | Journal |
|---|---|
| Do Slit-Lamp Shields and Face Masks Protect Ophthalmologists amidst COVID-19?. Ong SC, Yap JX, Tay TYF, Mo Y, Loon SC, Koh V |
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| Evolving Practice Patterns in Singapore's Public Sector Ophthalmology Centers During the COVID-19 Pandemic. Khor WB, Yip L, Zhao P, Foo VHX, Lim L, Ting DSW, Loon SC, Wong E, Yong V, Tan C, Wong TY, Wong HT |
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| Considerations in the use of slit lamp shields to reduce the risk of respiratory virus transmission in coronavirus disease 2019. Lim JYE, Cecilia AM, Lim KAD, Sng C, Loon SC, Lun WXK, Chew TKP, Koh TCV |
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| Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 1: Guidelines for Initiating Antitubercular Therapy in Tubercular Choroiditis. Agrawal Rupesh; Testi Ilaria; .Mahajan Sarakshi; Yuen Yew Sen; Agarwal Aniruddha; Kon Onn Min; Barisani-Asenbauer Talin;.Kempen John H; Gupta Amod; 1Jabs Douglas A; Smith Justine R; Nguyen Quan Dong; Pavesio Carlos; Gupta Vishali; 1Collaborative Ocular Tuberculosis Study Consensus Group; |
| Title |
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| A study of sports-related orbital fractures in Singapore. Lock JZ, Hegde R, Young S, Lim TC, Amrith S, Sundar G |
| Association of iris crypts with acute primary angle closure. Koh V, Chua J, Shi Y, Thakku SG, Lee R, Nongpiur ME, Baskaran M, Kumar RS, Perera S, Aung T, Cheng CY |
| Bilateral simultaneous infective keratitis. Annie LH, Ray M |
| Canaliculorhinostomy—Indications and Surgical Results. Lee JH, Young SM, Kim Y, Woo KI, Yum J |
| Caution in Using the XEN-augmented Baerveldt Surgical Technique. Sng CCA, Wang J, Barton K |
| Central corneal thickness in glaucoma. Sng CCA, Ang M, Barton K |
| Clinical Features and Treatment Outcomes of Orbital Inflammatory Disease in Singapore: A 10-Year Clinicopathologic Review. Young SM, Chan ASY, Jajeh IA, Shen S, Seah LL, Choo CT, Lang SS, Looi ALG |
| Clinical Use of Curcumin in Depression: A Meta-Analysis. Ng QX, Koh SSH, Chan HW, Ho CYX |
| Comparing the use of phacoemulsification and combined surgery in angle-closure glaucoma. Teoh CS, Aquino MC, Loon SC, Chew P, Koh V |
| Doll therapy for dementia sufferers: A systematic review. Ng QX, Koh SSH, Tan WC, Chan HW |
| Macular Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Children with Refractive Errors-An Optical Coherence Tomography Study. Goh JP, Koh V, Chan YH, Ngo C |
| Managing childhood and adolescent attention-deficit/hyperactivity disorder (ADHD) with exercise: A systematic review. Ng QX, Ho CYX, Chan HW, Yong BZJ, Yeo W |
| Microinvasive Glaucoma Surgery. Sng CCA, Harasymowycz P, Barton K |
| Mutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counselling. Tomar S, Sethi R, Sundar G, Quah TC, Quah BL, Lai PS |
| Ophthalmic involvement in nasopharyngeal carcinoma. Wong WM, Young SM, Amrith S |
| Outcomes of levator advancement and Müller muscle-conjunctiva resection for the repair of upper eyelid ptosis. Thomas GN, Chan J, Sundar G, Amrith S |
| Quantitative analysis of en face spectral-domain optical coherence tomography imaging in polypoidal choroidal vasculopathy. Simonett JM, Chan EW, Chou J, Skondra D, Colon D, Chee CK, Lingam G, Fawzi AA |
| Quantitative Changes in Pigment Epithelial Detachment Area and Volume Predict Retreatment in Polypoidal Choroidal Vasculopathy. Chan EW, Eldeeb Mb, Lingam G, Thomas D, Bhargava M, Chee CK |
| Radiologic Parameters of Orbital Bone Remodeling in Thyroid Eye Disease. Tan NYQ, Leong YY, Lang SS, Htoon ZM, Young SM, Sundar G |
| Safety and Efficacy of Microinvasive Glaucoma Surgery. Chen D, Sng CCA |
| Success rates of 2-site phacoemulsification combined with fornix-based trabeculectomy using mitomycin C for primary angle-closure glaucoma and primary open-angle glaucoma in an Asian population. Koh V, Chen D, Aquino CM, Aduan J, Sng C, Chee LS, Chew P |
| Surgical Treatment of Angle-Closure Glaucoma. Lim D, Aquino MC, Chew P |
| The Effect of Testing Reliability on Visual Field Sensitivity in Normal Eyes. The Singapore Chinese Eye Study. Tan NYQ, Tham YC, Koh V, Nguyen DQ, Cheung CY, Aung T, Wong TY, Cheng CY |
| Use of bioresorbable implants for orbital fracture reconstruction. Young SM, Sundar G, Lim TC, LangSS, Thomas G, Amrith S |