16 Jun 2025
NUS Medicine study finds key blood proteins which predict future cognitive decline
In a study that holds significance for individuals with cerebrovascular disease, scientists from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have found proteins in the blood that predict future cognitive decline and dementia.
Led by Professor Christopher Chen, Deputy Chair of the Healthy Longevity Translational Research Programme (TRP) at NUS Medicine, this first-of-its-kind study in Singapore analysed more than 1,000 proteins in the blood of a local patient cohort. The study was conducted on 528 patients from memory clinics at the National University Hospital (NUH) and St Luke’s Hospital in Singapore.
Professor Arthur Mark Richards, co-senior author of the paper published in Alzheimer’s and Dementia, said, “One of our findings was the characterisation of a blood protein signature for future cognitive decline. Using advanced proteomic technologies, we profiled over a thousand blood proteins tied to neurodegeneration, inflammation, and vascular dysfunction, which are key contributors to dementia.” Prof Richards is from the Cardiovascular-Metabolic Diseases TRP at NUS Medicine.
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