Equipment / Capabilities
Multiplex magnetic bead system – MILLIPLEX® with Luminex® INTELLIFLEX®
- Applications
- Detection and quantification of biomarkers, proteins from various sample types including:
- Cell culture supernatant
- Body fluids e.g. plasma, tissue lysates
- Detection and quantification of biomarkers, proteins from various sample types including:
- Benefits
- Analyse up to 500 biomarkers in a sample with minimum 25µL simultaneously
- Both 96 and 384 well supported
- Improvements from previous Luminex® systems
- Faster Read Time (96-well plate ~20 mins)
- Broader dynamic range (≥5.5 logs)
- Large range of commercial kits to choose from their website
Multiplex magnetic bead system – MILLIPLEX® with Luminex® MAGPIX® System
- Applications
- Detection and quantification of biomarkers, proteins
- Detection and quantification of biomarkers, proteins
- Benefits
- Analyse up to 50 biomarkers in a sample with minimum 25µL simultaneously
- High-throughput
- Large range of commercial kits to choose from their website
Cytation™ 3 imaging system
- Applications
- Live-cell imaging and analysis
- Cell proliferation and cytotoxicity studies
- Protein expression and quantification
- Drug testing and development
- Biomarker quantification
- Benefits
- Samples can be in microplates, microscope slides, T25 flasks or petri dishes
- For either endpoint, time lapse, montage assays
- Images produced are good enough quality for publication
Flexstation® 3 multi-node microplate reader with integrated programmable liquid handling system
- Applications
- Absorbance, Fluorescence and Luminescence
- Endpoint and kinetic assays including
- ELISA, Enzyme Activity
- ADME-Tox Assays
- Reporter Gene Assay
- Benefits
- Automated pipetting: 8/16 channel pipettor into 96 or 384 well plates
- Particularly useful in in-vitro kinetic assays
- User-based assay optimization
- Automated pipetting: 8/16 channel pipettor into 96 or 384 well plates
Leica fully motorized upright THUNDER imager (3D tissue)
- Applications
- Brightfield, DIC prepared, fluorescence views
- High speed, resolution, throughput, contrast enhancement, real-time, de-blurred 3D tissue or cell imaging.
- Benefits
- Fully automated tissue imaging system: records multi-colour 3D images in real time
- Imaging of challenging thick tissue sections: Z-stacking of single plane images
- Option to choose from a range of objectives, fluorescence filters
- Instant removal of out-of-focus fluorescent images
Tecan Spark 10M
- Applications
- ELISA, protein quantification, reporter gene assays
- Detection modes include
- Absorbance, Fluorescence, Luminescence, etc.
- Automated live cell imaging, confluence assessments
- FRET, TR-FRET
- Benefits
- Temperature control
- Increased format flexibility and sample throughput
- Up to 384 wells, cuvettes
- Automated microscope: cell counting using brightfield image
gentleMACS™ Octo Dissociator with heaters
- Applications
- Fully automated tissue dissociation into single-cell suspension of almost any biological material
- Species types include: mouse, human, rat
- Sample types include: tumours, heart, neural tissue, lung, spleen, liver, skeletal muscle, etc.
- Benefits
- Sample preparation in sterile gentleMACS tubes (C-tubes sold at additional cost)
- User-defined programs for easier workflow and reproducibility
- Plug and play sample dissociation
- Heaters allow for enzymatic and mechanical dissociation
Desktop freezer dryer- Labconco® FreeZone® 4.5 Plus
- Applications
- Lyophilization of therapeutics, chemical samples/products
- Other types of samples that can be lyophilized:
- Bacteria, yeast, and probiotics
- Biomedical products including Clotting factors
- Food for processing and preservation
- Benefits
- Post lyophilized product preserves its original shape, and can be rehydrated if required
Electric cell-substrate impedance sensing system (ECIS)
- Applications
- Quantifying cell activity in tissue culture in real time
- In terms of morphological changes, cell locomotion, etc.
- Investigating
- Cancer cell invasion, in vitro toxicity testing, GPCRs involved in signal transduction
- Quantifying tight junctions, BBB integrity
- Quantifying cell activity in tissue culture in real time
- Benefits
- In vitro barrier integrity: Trans-epithelial/endothelial electrical resistance (TEER)
- Non invasive to cell layer
- Label free measurement
- In vitro barrier integrity: Trans-epithelial/endothelial electrical resistance (TEER)
UHPLC – Agilent 1290 Infinity II LC System
- Applications
- Separation, identification, quantification of sample constituents, including purity determination
- Various sample types including food and pharmaceuticals for amino acid analysis
- Compound analysis of e.g. plant based samples
- Benefits
- High speed pump including active damping (reduction of UV noise)
- High capacity sampler with internal temperature regulation and customizable injection program
- Variable wavelength detector capable of e.g. fast analysis, detection of trace level components dual-wavelength mode
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