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Assistant Professor Queenie Li Ling Jun

Assistant Professor Queeniee Li Ling Jun

Assistant Professor Queenie Li Ling Jun

obgllj@nus.edu.sg

There is a strong lifecourse perspective around the world with a focus on the health of populations, especially in women. In Dr Li’s early career in research, she used advanced retinal imaging technology and state-of-the-art computer-based image analysis to study pregnancy outcomes and early life diseases. By examining retinal microvascular function and structure—a “window” of general microcirculation in vivo—her research investigated its diagnostic and predictive values in relation to maternal (gestational diabetes and gestational hypertension) and child health outcomes (fetal growth restriction and childhood obesity). The scope of Dr Li’s research has resulted in over 40 publications and established her expertise in the field of retinal imaging. Subsequently, Dr Li's research program focuses on the determinants and transgenerational health consequences of maternal obesity and diabetes based on a life course approach. More specifically, her current research activities focus primarily on the roles of comprehensive pre-conceptual and antenatal factors using biospecimens in the pathogenesis of gestational diabetes and transgenerational health consequences. She believes that such long-standing research interests in fetal origins of chronic diseases, life course epidemiology and modifications of diet and lifesylte will improve reproductive outcomes and health in both mother and child. Moreover, Dr Li’s research interest has also expanded to feasible and effective intervention programs including tele-medical approach to modify personal behaviours in pregnant women who are at risk of gestational diabetes during pregnancy and prediabetes or type 2 diabetes after delivery.

Publications

  1. Li, L. J., Cheung, C. Y., Liu, Y., Chia, A., Selvaraj, P., Lin, X. Y., Chan, Y. M., Varma, R., Mitchell, P., Wong, T. Y., & Saw, S. M. (2011). Influence of blood pressure on retinal vascular caliber in young children. Ophthalmology, 118(7), 1459–1465. https://doi.org/10.1016/j.ophtha.2010.12.007
  2. Li, L. J., Cheung, C. Y., Ikram, M. K., Gluckman, P., Meaney, M. J., Chong, Y. S., Kwek, K., Wong, T. Y., & Saw, S. M. (2012). Blood pressure and retinal microvascular characteristics during pregnancy: Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study. Hypertension (Dallas, Tex. : 1979), 60(1), 223–230. https://doi.org/10.1161/HYPERTENSIONAHA.112.195404
  3. Li, L. J., Tan, K. H., Aris, I. M., Chong, Y. S., Saw, S. M., Gluckman, P., Wang, J. J., & Wong, T. Y. (2017). Gestational retinal microvasculature and the risk of 5 year postpartum abnormal glucose metabolism. Diabetologia, 60(12), 2368–2376. https://doi.org/10.1007/s00125-017-4441-x
  4. Li, L. J., Tan, K. H., Aris, I. M., Man, R., Gan, A., Chong, Y. S., Saw, S. M., Gluckman, P., Wong, T. Y., & Lamoureux, E. (2018). Retinal vasculature and 5-year metabolic syndrome among women with gestational diabetes mellitus. Metabolism: clinical and experimental, 83, 216–224. https://doi.org/10.1016/j.metabol.2017.10.004
  5. Li, L. J., Rifas-Shiman, S. L., Aris, I. M., Mantzoros, C., Hivert, M. F., & Oken, E. (2019). Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence. Metabolism: clinical and experimental, 91, 30–38. https://doi.org/10.1016/j.metabol.2018.11.003
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