Dr Png Chin Wen

Png Chin Wen

PhD

Lecturer

Department of Microbiology and Immunology

Email: micpcw@nus.edu.sg

Tel: 6516 3319

Research Theme

Gastrointestinal diseases and microbiome

Gut inflammation and cancers account for more than half of all gastrointestinal diseases. Development of these pathologies involve multiple factors such as host genetics, immune responses and environmental factors. In addition, alterations of various cellular signalling processes are implicated in every aspect of disease pathogenesis. More recently, gut microbiome was shown to be important for the maintenance of overall health. Other than gut diseases, altered composition of gut microbes is also associated with illnesses such as diabetes, liver and neurodegenerative disorders. Currently, we focus on understanding the complex cellular signalling that influence colorectal cancer progression, in order to identify potential targets for therapeutic intervention. At the same time, we work closely with clinicians to examine the correlation of gut microbiota with disease development in patients.

Recent Publications

  1. Low HB, Wong ZL, Wu BY, Kong LR, Png CW, Cho YL, Li CW, Xiao FC, Xin X, Yang H, Loo JM, Fiona Yi Xin Lee Fiona YX, Tan Iain BH, DasGupta R, Shen HM, Schwarz H, Gascoigne NRJ, Goh BC, Xu XH, Zhang YL. DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Nature Communications (2021) 12: 2284.
  2. Ng ZL, Siew JM, Li J, Ji GX, Huang M, Liao XH, Yu S, Chew YY, Png CW, Zhang YL, Wen SJ, Yang H, Zhou YT, Long YC, Jiang ZH, Wu Q. PATZ1 (MAZR) Co-occupies Genomic Sites With p53 and Inhibits Liver Cancer Cell Proliferation via Regulating p27. Front Cell Dev Biol (2021) 9:586150.
  3. Tang Peng, Low HB, Png CW, Torta F, Kumar JK, Lim HY, Zhou Y, Yang Henry, Angeli V, Shabbir A, Tai ES, Flavell RA, Chen Dong, Wenk MR, Yang DY, Zhang YL. Protective function of mitogen-activated protein kinase phosphatase 5 in aging- and diet-induced hepatic steatosis and steatohepatitis. Hepatol Commun. (2019) 3:748-762.
  4. Yason JA, Liang YR, Png CW, Zhang YL, Tan KSW. Interactions between a pathogenic Blastocystis subtype and gut microbiotaL in vitro and in vivo studies. Microbiome. (2019). 7:30
  5. Cho SSL, Han L, James, SJ, Png CW, Weeasooriya M, Alonso S, Zhang YL. Dual-specificity phosphatase 12 targets p38 MAP Kinase to regulate macrophage response to Intracellular bacterial infection. Front Immunol. (2017). 8: 1259
  6. Png CW, Weerasooriya M, Guo J, James SJ, Poh HM, Osato M, Flavell RA, Dong C, Yang H, Zhang YL. DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. Oncogene (2016). 35:206-17
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