MACC Funding

Cumulative Funding Awarded since 2010 (SGD)
$ 0 ++

The Memory, Ageing and Cognition Centre has successfully secured substantial funding over the years, reflecting its pivotal role in advancing research in these critical areas. These funds have been obtained from a variety of local and international sources, underscoring the centre’s reputation and the importance of its work. Below, you will find a timeline containing information on the total fundings obtained, illustrating the Centre’s capacity to drive impactful research and innovation.

2024

2024

  • The Pilot ImplemenTation of Quick Dementia Rating Scale in Community Health Posts (PITCH) Study (HPHSR-Enabling-Sep24/AHP/C09/CC). PI: C Chen SGD44,300
  • Advancing precision neuromodulation through individualised brain maps using functional connectivity and in-vivo electrophysiology. NMRC Research Training Fellowship. (RTF24Jan-005). PI: M Lim Mentor: C Chen SGD490,000
  • Extended follow-up to examine the impact of a multidomain lifestyle intervention for the prevention of cognitive decline and frailty – SINGER extended follow up (PHRGOC23jul-0008). PI: C Chen SGD1,500,000
  • NUS-NUHS HPHSR Enabling Grant. Towards Precision Medicine for Dementia in Singapore. Co-PIs: M. Lai & MA Sim, Mentor C. Chen SGD50,000
2024

2023

2023

  • Blood-based Biomarkers in Neurocognition and Aging (NCSP2.0/2023/NUHS/SMA). PI: MA Sim, Mentor: C Chen. SGD400,000
  • The TEMPO Study, A Deep-Learning Derived Multisystem Retinal-Blood Biomarker Index for Prediction of Dementia. NUS Clinician Scientist Development Unit Katong Collaboration Grant (KCG/2023/NUSMED/SMA). PI: MA Sim, Mentor: C Chen. SGD45,500 
  • The Pilot ImplemenTation of Quick Dementia Rating Scale in Community Health Post (PITCH) Study  (NUHSRO/2022/098/RO5+6/HPHSR(Collab)-2022/01). PI: C Chen, SGD250,000
  • PREdiction and PAThophysiology of Cognitive Health in Spontaneous IntraCerebral Hemorrhage (the PREPATCH-SICH) Study (NCSP2.0/2023/NUHS/ML). PI: Dr. M Lim, Mentor: C Chen, SGD400,000 
  • The GENESIS STUDY: discoverinG novEl blood-based biomarkers aNd proteomic SIgnatureS of neurocognition and aging. 2023-2027. NMRC Research Training Fellowship (MH 095:003/008-340). PI: MA Sim, Mentor: C Chen. SGD366,500
  • National Academy of Medicine, NMRC Healthy Longevity Catalyst Award. Investigating Associations Between Biological Age measured by Blood-Based DNA Methylation, with Cognitive Performance, Neuroimaging Markers and Conversion to Dementia. PI: MA Sim, Mentor: C. Chen. SGD177,239.40
2023

2022

2022

  • Elucidating the role of inflammasome as pathogenic factors, biomarkers and therapeutic targets for Alzheimer’s disease and vascular cognitive impairment, (MOH-001086-00) – National Medical Research Council. PI: C Chen. SGD1,500,000
2022

2021

2021

  • Prevention of and Biomarkers for Vascular Cognitive Impairment. National Medical Research Council (NMRC/OFLCG/2019). PI: C Chen SGD10,000,000
  • Validating Existing and Emerging Multi-modal Biomarkers of Vascular Cognitive Impairment (MOH-000707) Singapore Translational Research Investigator Award. PI : C Chen. SGD5,995,800
  • INTEgRating bRain, Eye And Cardiac Research (INTER-REACH) : How the Scarecrow found a Brain, the Lion Vision to locate Courage and the Tin Man a Heart (CG21APR2010). PI : C Chen SGD4,000,000
2021

2019

2019

  • NUS-USYD Strategic Partnership 2019 – Intensive targeting of blood pressure to reduce dementia and small‐vessel disease in individuals who have survived an intracerebral haemorrhage: a multi‐site double‐blind placebo controlled randomized controlled trial and cognitive validity study, SGD9,925
  • DDOP Clinical trial – Clinical assessment of the use of reverse transcriptase inhibitors in patients with mild cognitive impairment, SGD341,000
2019

2018

2018

  • Machine learning tools for personalised diagnosis in dementia, PI: A/Prof Christopher Chen. SGD121,720
  • MACC Biomarker Discovery Bridging Fund, (NUHSCG/2017/Bridging/01 (NMRC/CG/M009/2017) – ). PI: A/Prof Christopher Chen. SGD100,000
  • SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER) Pilot study, (Functionalageing/SINGER/FY2018). PI: A/Prof Christopher Chen. SGD420,000
  • Mechanisms of decline in vascular cognitive impairment (NMRC/CIRG/1485/2018), PI: A/Prof Christopher Chen. SGD1,493,000
2018

2017

2017

  • Translational Research in Vascular Biomarkers of Dementia: Discovery, Validation and Assessment of Clinical Utility (NMRC/CSA-SI/0007/2016); PI: A/Prof Christopher Chen. SGD1,750,000
  • Novel retinal imaging biomarkers for cognitive decline, Health and Medical Research Fund (application no. 04153506); Collaborator: A/Prof Christopher Chen (PI: Asst/Prof Carol Cheung Yim-Lui). HKD1,190,482
  • Telomere length as a peripheral biomarker of cerebrovascular disease and neurodegeneration in dementia, NUHS O-CRG 2016 Oct -24; Co-I: A/Prof Christopher Chen (PI: Asst/Prof Mitchell Lai). SGD179,999
  • Targeting Age-Associated White Matter Lesions, AMED2016-SG013; Co-I: A/Prof Christopher Chen (PI: Prof Peter Wong). SGD250,000
  • Cognitive and neuropsychiatric profiles of amyloid burden and cerebrovascular disease in elderly with mild cognitive impairment (NUHSRO/2017/014/Cambridge/01); NUHS PI: A/Prof Christopher Chen, Cambridge PI: Prof John O’Brien. SGD30,000
  • Diabetes, Tuberculosis and Neuroscience Core 4 – Neuro Cognitive Core (NUHS MCG CORE 4 NCC OOE / EOM – Centre Grant); PI: A/Prof Christopher Chen. SGD552,271 (disbursed in 2018)
2017

2016

2016

  • The Alzheimer’s disease THErapy with NEuroaid (ATHENE) Study : Assessing the Safety and Efficacy of Neuroaid II (MLC901) in patients with mild to moderate Alzheimer’s disease stable on Cholinesterase inhibitors or Memantine: A Randomized, double blind, placebo controlled trial (NMRC/MOHIAFCat1/0060/2016); PI: A/Prof Christopher Chen. SGD675,000
  • An investigation of visual speed of processing in MCI patients, NUHS CIRC Core Seed Funding ; PI: A/Prof Christopher Chen. SGD49,700
  • Ocular Markers of Alzheimer’s Disease: OMEGA Study, DUKE/DUKE-NUS Research Collaboration Pilot Project; Co-I: A/Prof Christopher Chen (PI: Prof Wong Tien Yin). SGD100,000
  • Etiology of Cortical Cerebral Microinfarcts and Impact on Brain Function and Long Term Outcomes (NMRC/CIRG/1446/2016); PI: A/Prof Christopher Chen. SGD1,472,463.02
2016

2015

2015

  • Correlating brain glutamate levels with cognitive function and amyloid burden in ApoE4 Alzheimer’s disease, NUHS CIRC Core Seed Funding; PI: A/Prof Christopher Chen SGD50,000
  • Preclinical and clinical investigations of neurodegeneration and age-associated cognitive impairments (NUHSRO/2014/102/AF-WORLDCLASS/01); Co-PI: A/Prof Christopher Chen (PI: Prof Carlos Ibanez). SGD2,000,000 (total approved grant budget)
2015

2013

2013

  • NUHS – Metabolic Medicine, Infectious Diseases, Neuroscience Enablers (MINE) – Cognitive Assessment Core, NMRC/CG/013/2013, NMRC Centre Grant; PI: A/Prof Christopher Chen. SGD3,100,000
  • The Feasibility and Validation of an Informant-Based Cognitive Screening Instrument in the Primary Healthcare Setting (HSRG/041/2013); PI: A/Prof Christopher Chen. SGD200,000
2013

2012

2012

  • Translational Research in Dementia: Mechanisms of Diseaes, Pathophysiology and Biomarker Discovery, NMRC/CSA/032/2011, Clinic Scientist Award (SI category); PI: A/Prof Christopher Chen SGD1,750,000
2012

2011

2011

  • Retinal Vascular Signs as Novel Biomarkers of Dementia, GSK ACE award. Co-PI: A/Prof Christopher Chen. SGD1,011,825
  • Chinese Medicine Neuroaid Efficacy on Stroke Recovery (CHIMES) Study, (NMRC/1288/2011); PI: A/Prof Christopher Chen. SGD743,677
2011

2010

2010

  • Memory Ageing and Cognition Centre, NMRC/CG/NUHS/2010, NUHS Centre Grant. PI: A/Prof Christopher Chen. SGD6,000,000 (April 2010 to March 2014)
2010