MACC Funding

Cumulative Funding Awarded since 2010 (SGD)

$ 0 ++

The Memory, Ageing and Cognition Centre has successfully secured substantial funding over the years, reflecting its pivotal role in advancing research in these critical areas. These funds have been obtained from a variety of local and international sources, underscoring the centre’s reputation and the importance of its work. Below, you will find a timeline containing information on the total fundings obtained, illustrating the Centre’s capacity to drive impactful research and innovation.

2026

Cognitive Resilience in Vascular Cognitive Impairment (StaR25Jul-002). PI: C Chen SGD3,076,923.08
Investigating Adipose Tissue derived Beta Amyloid aggregates’ role in Alzheimer’s Disease (MOE-T2EP30125-0012). PI: D Leong, CO-PI: C Chen sub-awarded SGD262,990.00
Evaluating the efficacy of ergothioneine to alter neurodegeneration and delay dementia onset (RGP-AY250717KSQFG). PI: C Chen SGD1,248,050.00

2025

Implementation of Digital dEtection of Cognitive Impairment and DEmentia in the community (I-DECIDE) (PHRGOC25jan-0036). PI: C Chen SGD1,500,000.00
Retina-Enhanced Cognitive-Impairment Opportunistic and Generative Neural Intelligent Screening Evaluation (RECOGNISE) (NICCOG2024-0029). PI: CY Cheng, CO-I: C Chen, sub-awarded SGD451,000.00

2024

The Pilot ImplemenTation of Quick Dementia Rating Scale in Community Health Posts (PITCH) Study (HPHSR-Enabling-Sep24/AHP/C09/CC). PI: C Chen SGD44,300
Advancing precision neuromodulation through individualised brain maps using functional connectivity and in-vivo electrophysiology. NMRC Research Training Fellowship. (RTF24Jan-005). PI: M Lim Mentor: C Chen SGD490,000
Extended follow-up to examine the impact of a multidomain lifestyle intervention for the prevention of cognitive decline and frailty – SINGER extended follow up (PHRGOC23jul-0008). PI: C Chen SGD1,500,000
NUS-NUHS HPHSR Enabling Grant. Towards Precision Medicine for Dementia in Singapore. Co-PIs: M. Lai & MA Sim, Mentor C. Chen SGD50,000.

2023

Blood-based Biomarkers in Neurocognition and Aging (NCSP2.0/2023/NUHS/SMA). PI: MA Sim, Mentor: C Chen. SGD400,000
The TEMPO Study, A Deep-Learning Derived Multisystem Retinal-Blood Biomarker Index for Prediction of Dementia. NUS Clinician Scientist Development Unit Katong Collaboration Grant (KCG/2023/NUSMED/SMA). PI: MA Sim, Mentor: C Chen. SGD45,500
The Pilot ImplemenTation of Quick Dementia Rating Scale in Community Health Post (PITCH) Study (NUHSRO/2022/098/RO5+6/HPHSR(Collab)-2022/01). PI: C Chen, SGD250,000
PREdiction and PAThophysiology of Cognitive Health in Spontaneous IntraCerebral Hemorrhage (the PREPATCH-SICH) Study (NCSP2.0/2023/NUHS/ML). PI: Dr. M Lim, Mentor: C Chen, SGD400,000
The GENESIS STUDY: discoverinG novEl blood-based biomarkers aNd proteomic SIgnatureS of neurocognition and aging. 2023-2027. NMRC Research Training Fellowship (MH 095:003/008-340). PI: MA Sim, Mentor: C Chen. SGD366,500
National Academy of Medicine, NMRC Healthy Longevity Catalyst Award. Investigating Associations Between Biological Age measured by Blood-Based DNA Methylation, with Cognitive Performance, Neuroimaging Markers and Conversion to Dementia. PI: MA Sim, Mentor: C. Chen. SGD177,239.40.

2022

Elucidating the role of inflammasome as pathogenic factors, biomarkers and therapeutic targets for Alzheimer’s disease and vascular cognitive impairment, (MOH-001086-00) – National Medical Research Council. PI: C Chen. SGD1,500,000

2021

Prevention of and Biomarkers for Vascular Cognitive Impairment. National Medical Research Council (NMRC/OFLCG/2019). PI: C Chen SGD10,000,000
Validating Existing and Emerging Multi-modal Biomarkers of Vascular Cognitive Impairment (MOH-000707) Singapore Translational Research Investigator Award. PI : C Chen. SGD5,995,800
INTEgRating bRain, Eye And Cardiac Research (INTER-REACH) : How the Scarecrow found a Brain, the Lion Vision to locate Courage and the Tin Man a Heart (CG21APR2010). PI : C Chen SGD4,000,000

2019

NUS-USYD Strategic Partnership 2019 – Intensive targeting of blood pressure to reduce dementia and small‐vessel disease in individuals who have survived an intracerebral haemorrhage: a multi‐site double‐blind placebo controlled randomized controlled trial and cognitive validity study, SGD9,925
DDOP Clinical trial – Clinical assessment of the use of reverse transcriptase inhibitors in patients with mild cognitive impairment, SGD341,000

2018

Machine learning tools for personalised diagnosis in dementia, PI: A/Prof Christopher Chen. SGD121,720
MACC Biomarker Discovery Bridging Fund, (NUHSCG/2017/Bridging/01 (NMRC/CG/M009/2017) – ). PI: A/Prof Christopher Chen. SGD100,000
SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER) Pilot study, (Functionalageing/SINGER/FY2018). PI: A/Prof Christopher Chen. SGD420,000
Mechanisms of decline in vascular cognitive impairment (NMRC/CIRG/1485/2018), PI: A/Prof Christopher Chen. SGD1,493,000

2017

Translational Research in Vascular Biomarkers of Dementia: Discovery, Validation and Assessment of Clinical Utility (NMRC/CSA-SI/0007/2016); PI: A/Prof Christopher Chen. SGD1,750,000
Novel retinal imaging biomarkers for cognitive decline, Health and Medical Research Fund (application no. 04153506); Collaborator: A/Prof Christopher Chen (PI: Asst/Prof Carol Cheung Yim-Lui). HKD1,190,482
Telomere length as a peripheral biomarker of cerebrovascular disease and neurodegeneration in dementia, NUHS O-CRG 2016 Oct -24; Co-I: A/Prof Christopher Chen (PI: Asst/Prof Mitchell Lai). SGD179,999
Targeting Age-Associated White Matter Lesions, AMED2016-SG013; Co-I: A/Prof Christopher Chen (PI: Prof Peter Wong). SGD250,000
Cognitive and neuropsychiatric profiles of amyloid burden and cerebrovascular disease in elderly with mild cognitive impairment (NUHSRO/2017/014/Cambridge/01); NUHS PI: A/Prof Christopher Chen, Cambridge PI: Prof John O’Brien. SGD30,000
Diabetes, Tuberculosis and Neuroscience Core 4 – Neuro Cognitive Core (NUHS MCG CORE 4 NCC OOE / EOM – Centre Grant); PI: A/Prof Christopher Chen. SGD552,271 (disbursed in 2018)

2016

The Alzheimer’s disease THErapy with NEuroaid (ATHENE) Study : Assessing the Safety and Efficacy of Neuroaid II (MLC901) in patients with mild to moderate Alzheimer’s disease stable on Cholinesterase inhibitors or Memantine: A Randomized, double blind, placebo controlled trial (NMRC/MOHIAFCat1/0060/2016); PI: A/Prof Christopher Chen. SGD675,000
An investigation of visual speed of processing in MCI patients, NUHS CIRC Core Seed Funding ; PI: A/Prof Christopher Chen. SGD49,700
Ocular Markers of Alzheimer’s Disease: OMEGA Study, DUKE/DUKE-NUS Research Collaboration Pilot Project; Co-I: A/Prof Christopher Chen (PI: Prof Wong Tien Yin). SGD100,000
Etiology of Cortical Cerebral Microinfarcts and Impact on Brain Function and Long Term Outcomes (NMRC/CIRG/1446/2016); PI: A/Prof Christopher Chen. SGD1,472,463.02

2015

Correlating brain glutamate levels with cognitive function and amyloid burden in ApoE4 Alzheimer’s disease, NUHS CIRC Core Seed Funding; PI: A/Prof Christopher Chen SGD50,000
Preclinical and clinical investigations of neurodegeneration and age-associated cognitive impairments (NUHSRO/2014/102/AF-WORLDCLASS/01); Co-PI: A/Prof Christopher Chen (PI: Prof Carlos Ibanez). SGD2,000,000 (total approved grant budget)

2013

NUHS – Metabolic Medicine, Infectious Diseases, Neuroscience Enablers (MINE) – Cognitive Assessment Core, NMRC/CG/013/2013, NMRC Centre Grant; PI: A/Prof Christopher Chen. SGD3,100,000
The Feasibility and Validation of an Informant-Based Cognitive Screening Instrument in the Primary Healthcare Setting (HSRG/041/2013); PI: A/Prof Christopher Chen. SGD200,000

2012

Translational Research in Dementia: Mechanisms of Diseaes, Pathophysiology and Biomarker Discovery, NMRC/CSA/032/2011, Clinic Scientist Award (SI category); PI: A/Prof Christopher Chen SGD1,750,000

2011

Retinal Vascular Signs as Novel Biomarkers of Dementia, GSK ACE award. Co-PI: A/Prof Christopher Chen. SGD1,011,825
Chinese Medicine Neuroaid Efficacy on Stroke Recovery (CHIMES) Study, (NMRC/1288/2011); PI: A/Prof Christopher Chen. SGD743,677