Associate Professor Sylvie Alonso

Appointment(s)

Assoc Professor, National University of Singapore, Dept of Microbiology, SINGAPORE
Assistant Professor, National University of Singapore, Dept of Microbiology, SINGAPORE
Research Fellow (Scale A), National University of Singapore, Dept of Microbiology, SINGAPORE

Degree(s)

Doctor of Philosophy
Masters

Biography

Professor Alonso obtained her PhD degree in Microbiology and Molecular Biology from the University Claude Bernard Lyon I (France) in 1998. She subsequently moved to Pasteur Institute of Lille (France) for a 4-year post-doctoral training where she developed bacterial vaccine delivery systems. Professor Alonso then spent 2 years at Cornell University (NY, USA) as a Research Fellow where she worked on Tuberculosis. In 2004, she was awarded the Lee Kuan Yew post-doctoral fellowship and joined the Department of Microbiology at the National University of Singapore Yong Loo Lin School of Medicine. She was recruited as an Assistant Professor in 2007 and promoted to Associate Professor with tenure in 2013.

Research Areas/Research Interest

1. Vaccine development
– Vaccine improvement by targeting Clec9A expressing dendritic cells:
– Dr Mireille Lahoud (Monash University, Australia) and Prof Ken Shortman (WEHI, Australia)

2. Host-pathogen interactions
Hand, Foot and Mouth Disease : Understanding EV71 Neurovirulence
– A/P Vincent Chow (NUS, Department of Microbiology)
-A/P Chu Justin (NUS, Department of Microbiology&Immunology)
-Dr October Sessions (Duke-NUS, Singapore)
-A/P Sze Newman (NTU, SBS)
– Dr Wan Yue (GIS)
-Dr Ng Shi Yan (IMCB)
-Dr Lisa Ng (IDLabs)
-Prof Huang Dejian (Food, Science&Technology, NUS)
Dengue: Understanding DENV virulence determinants
-A/P Ng Lee Ching, NEA
-Prof Subash Vasudevan (Duke-NUS)
– A/P Sheemei LOK (Duke-NUS)
– A/P Paul Macary (NUS, Department of Microbiology)
-Industry partner: FNDR

Selected Publications

Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in mice

Cheang YZN, Tan KS, Tan PS, Purushotorma K, Yap MC, Tullett MK, Chua YLB, Yeoh YYA, Tan QHC, Qian X, Chen H, Tay JWD, Caminschi I, Tan YJ, Macary PA, Tan CW, Lahoud MH, and Alonso S (2024).

A single-shot vaccine approach for the universal influenza A vaccine candidate M2e

Kavishna R, Kang TY, Vacca M, Chua YL, Park HY, TAN PS, Chow VTK, Lahoud M, Alonso S (2022).

A Single Amino Acid Substitution in Structural Protein VP2 Abrogates the Neurotropism of Enterovirus A-71 in Mice

Yeo H, Chong WC, Chen WE, Lim ZQ, Ng QY, Yan B, Chu JJH, Chow VTK, Alonso S (2022).

Mitochondria-mediated oxidative stress during viral infection

Foo J, Bellot G, Pervaiz S, S Alonso (2022).

Viral determinants that drive Enterovirus-A71 fitness and virulence

Ang Pei Yi, Chong WHC, Alonso S (2021).

Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system

Lim ZQ, Ng QY, OO Y, Chu JJH, Ng SY, Sze SK, Alonso S (2021).

Relative contribution of non-structural protein 1 in dengue pathogenesis

Lee PX, Ting DHR, Boey CPH, Tan ETX, Chia JZH, Idris F, Oo Y, Ong LC, Chua YL, Hapuarachchi C, Ng LC, Alonso S (2020).