Speaker: Joanes Grandjean, Research Fellow, Singapore BioImaging Consortium (SBIC), A*STAR

Functional imaging has been extensively used to map the human brain, to localize brain activity evoked by specific cognitive tasks or estimate large-scale brain networks during rest in the healthy and diseased brain. Advances in high-field magnets now enable researchers to extend these researches to animal models, where brain circuits can be dissected in details. Studies in animal models offer a translational perspective to investigate the cellular mechanisms behind (f)MRI-based fingerprints. In this talk, I will detail advances made to understand the mechanisms leading to large-scale neuronal networks re-organisation in the context of depression using high-field MRI and optogenetics.