Appointment(s)
Distinguished Professor of Biochemistry & Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Director, Centre for Healthy Longevity, National University Health System
Programme Director, Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore
Director, NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore
Degree(s)
Ph.D. in Biology , Massachusetts Institute of Technology, Cambridge, MA, USA (1996)
B.A. in Biochemistry and Mathematics, Northwestern University , Evanston , IL, USA (1989)
Biography
Professor Brian Kennedy is a Distinguished Biochemistry Professor in the Departments of Biochemistry and Physiology and serves as the Director of the Healthy Longevity Translational Research Programme and the Bia-Echo Asia Centre for Reproductive Longevity and Equality, National University of Singapore Yong Loo Lin School of Medicine. In addition, he is also the Director of the Centre for Healthy Longevity, National University Health System. Collectively, NUS ageing research seeks to demonstrate that longevity interventions can be successfully employed in humans to extend healthspan, the disease-free and highly functional period of life.
As a leading longevity researcher, Professor Kennedy’s research has been focused on delineating mechanisms driving biological ageing and identifying interventions that extend healthspan and lifespan. His work was instrumental in uncovering roles for Sirtuins and the mTOR pathway in regulating ageing. More recently, he has also focused on ageing biomarker development.
From 2010 to 2016, Professor Kennedy was the President and CEO of the Buck Institute for Research on Aging and he maintained a professorship there through 2020. He has an adjunct appointment in the Department of Biochemistry at the University of Washington, where he was a faculty member from 2001 to 2010, and at the Davis School of Gerontology at USC. His Ph.D. was performed in the laboratory of Leonard Guarente at M.I.T., where he published the first paper linking Sirtuins to ageing.
Professor Kennedy served as Co-Editor-In-Chief at Aging Cell from 2011-2021 and has a long track record of collaboration with scientists in China, where he was a Visiting Professor at the Aging Research Institute at Guangdong Medical College from 2009 to 2014.
Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention. Nat. Aging doi: 10.1038/s43587-024-00646-8. PMID: 38898237. (IF:16.6)
Fong, S., Pabis, K., Latumalea, D., Dugersuren, N., Unfried, M., Tolwinski, N., Kennedy, B., and Gruber J.
A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence. Elife. doi: 10.7554/eLife.87811. PMID: 38567944. (IF:7.7)
Pabis, K., Barardo, D., Sirbu, O., Selvarajoo, K., Gruber, J. and Kennedy, B.K.
Validation of biomarkers of aging. Nat. Med. 30(2):360-372. PMID: 38355974. (IF82.9)
Moqri, M., Herzog, C., Poganik, J.R., Ying, K., Justice, J.N., Belsky, D.W., Higgins-Chen, A.T., Chen, B.H., Cohen, A.A., Fuellen, G., Hägg, S., Marioni, R.E., Widschwendter, M., Fortney, K., Fedichev, P.O., Zhavoronkov, A., Barzilai, N., Lasky-Su, J., Kiel, D.P., Kennedy, B.K., Cummings, S., Slagboom, P.E., Verdin, E., Maier, A.B., Sebastiano, V., Snyder, M.P., Gladyshev, V.N., Horvath, S. and Ferrucci, L.
Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)-intervention study protocol. Geroscience 45:2897-2907. PMID: 37217632. (IF:5.6)
Sandalova, E., Goh, J., Lim, X.Z., Lim, Z.M., Barardo, D., Dorajoo, R., Kennedy, B.K. and Maier, A.B.
Taurine deficiency as a driver of aging. Science doi: 10.1126/science.abn9257 PMID: 37289866. (IF: 56.9)
Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M.A., Chamoli, M., Shi, S.L., Lopes Bastos, B., Nair, T., Riermeier, A., Vayndorf, E.M., Wu, J.Z., Nilakhe, A., Nguyen, C.Q., Muir, M., Kiflezghi, M.G., Foulger, A., Junker, A., Devine, J., Sharan, K., Chinta, S.J., Rajput, S., Rane, A., Baumert, P., Schönfelder, M., Iavarone, F., di Lorenzo, G., Kumari, S., Gupta, A., Sarkar, R., Khyriem, C., Chawla, A.S., Sharma, A., Sarper, N., Chattopadhyay, N., Biswal, B.K., Settembre, C., Nagarajan, P., Targoff, K.L., Picard, M., Gupta, S., Velagapudi, V., Papenfuss, A.T., Kaya, A., Ferreira, M.G., Kennedy, B.K., Andersen, J.K., Lithgow, G.J., Ali, A.M., Mukhopadhyay, A., Palotie, A., Kastenmüller, G., Kaeberlein, M., Wackerhage, H., Pal, B., Yadav, V.K.
Distinct biological ages of organs and systems identified from a multi-omics study. Cell Rep. 2022 Mar 8; 38(10):110459. PMID: 35263580. (IF: 9.423)
Nie, C., Li, Y. Li, R., Yan, Y., Zhang, D., Li, T., Li, Z., Sun, Y., Zhen, H., Ding, J., Wan, Z., Gong, J., Shi, Y., Huang, Z., Wu, Y., Cai, K., Zong, Y., Wang, Z., Wang, R., Jina, M., Yang, H., Han, J.J., Zhang, X., Franceschi, C., Kennedy, B.K., and Xu, X.
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test, Aging In press. PMID: 34847066. Aging (Albany NY) 2021 Nov 30;13(22):24485-24499. doi: 10.18632/aging.203736. Epub 2021 Nov 30. (IF: 5.955)
Demidenko, O. Barardo, D., Budovskii, V., Finnemore, R., Palmer, F.R., Kennedy, B.K., and Budovskaya, Y.V.
Alpha-Ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metab. 2020 Sep 1;32(3):447-456.e6 PMID: 32877690. (IF: 29)
Shahmirzadi, A.A., Edgar, D., Liao, C.Y., Hsu, Y.M., Lucanic, M., Shahmirzadi, A.A., Wiley, C.D., Gan, G., Kim, D.E., Kasler, H.G., Kuehnemann, C., Kaplowitz, B., Bhaumik, D., Riley, R.R., Kennedy, B.K., Lithgow, G.J.
The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging. Cell Met. 23: 990-1003. PMID: 27304501. (IF: 29)
Kennedy, B.K. and Lamming, D.W.
Activated muscle 4E-BP1 signaling improves metabolic parameters during aging and obesity. J. Clin. Invest. 125: 2952-2964. PMID: 26121750. (IF: 15.9)
Tsai, S., Sitzmann, J.M., Dastidar, S.G., Rodriguez, A.A., Vu, S.L., McDonald, C.E., Academia, E.C., O’Leary, M.N., Ashe, T.D., La Spada, A.R. and Kennedy B.K.
