Appointment(s)
Assistant Dean (Graduate Studies), Yong Loo Lin School of Medicine, National University of Singapore
Research Director (Department of Paediatrics),Yong Loo Lin School of Medicine, National University of Singapore
Principal Investigator (Cardiovascular and Metabolic Disease Translational Research Programme), Yong Loo Lin School of Medicine, National University of Singapore
Degree(s)
Doctor of Philosophy (PhD), Human Genetics, Yong Loo Lin School of Medicine, National University of Singapore
Bachelor of Science (Honours), Microbiology, Yong Loo Lin School of Medicine, National University of Singapore
Biography
Dr. Heng’s primary research focus lies in the genetic epidemiology of coronary artery disease (CAD) and the application of genomic data for the early detection of individuals at risk. As the Principal Investigator of the Singapore Coronary Artery Disease Genetics Study (SCADGENS), he has overseen the enrollment and data acquisition of over 3,000 CAD patients. The resulting biospecimens and database of genotypes and phenotypes constitute a valuable resource for cardiovascular research.
(2022) The association of genetic susceptibility to smoking with cardiovascular disease mortality and the benefits of adhering to a DASH diet: The Singapore Chinese Health Study. Am J Clin Nutr 116:386-393.
Geng T, Chang X, Wang L, Liu G, Liu J, Khor CC, Neelakantan N, Yuan JM, Koh WP, Pan A, Dorajoo R, Heng CK
(2022) A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study. Eur Heart J. 43:1702-1711.
Lu X, Liu Z, Cui Q, Liu F, Li J, Niu X, Shen C, Hu D, Huang K, Chen J, Xing X, Zhao Y, Lu F, Liu X, Cao J, Chen S, Ma H, Yu L, Wu X, Wu X, Li Y, Zhang H, Mo X, Zhao L, Huang J, Wang L, Wen W, Shu XO, Takeuchi F, Koh WP, Tai ES, Cheng CY, Wong TY, Chang X, Chan MY, Gao W, Zheng H, Chen K, Chen J, He J, Tang CS, Lam KSL, Tse HF, Cheung CYY, Takahashi A, Kubo M, Kato N, Terao C, Kamatani Y, Sham PC, Heng CK, Hu Z, Chen YE, Wu T, Shen H, Willer CJ, Gu D
(2021) The power of genetic diversity in genome-wide association studies of lipids. Nature 600:675-679.
Graham SE, Clarke SL, Wu KH et al
(2021) Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population. Atherosclerosis. 349:160-165.
Loh WJ, Chang X, Aw TC, Phua SK, Low AF, Chan MY, Watts GF, Heng CK.
(2019) Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies. Nat Commun.10:2491.
Dorajoo R, Chang X, Gurung RL, Li Z, Wang L, Wang R, Beckman KB, Adams-Haduch J, M Y, Liu S, Meah WY, Sim KS, Lim SC, Friedlander Y, Liu J, van Dam RM, Yuan JM, Koh WP, Khor CC, Heng CK
(2020) Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease. PLOS ONE 15(8): e0237074
Ooi DSQ, Ong SM, Eng MH, Chan YH, Lee YS, et al.
(2016) Utility of genetic and non-genetic risk factors in predicting coronary heart disease in Singaporean Chinese. Eur J Prev Cardiol. 24:153-160.
Chang X, Salim A, Dorajoo R, Han Y, Khor CC, van Dam RM, Yuan JM, Koh WP, Liu J, Goh DY, Wang X, Teo YY, Friedlander Y, Heng CK
