Faculty Staff

Victor Lee Kwan Min

MBBS, FRCPA
Assistant Professor
Senior Consultant
Soft tissue and bone tumour pathology,
Department of Pathology

Fellow of the Royal College of Pathologists Australasia.
British International Academy of Pathology – member.
Soft tissue registry member (Royal College of Pathologist Australasia) – panel member.
International Society for bone and soft tissue pathology – member.

Tel: +65 6772 4381
Email:

Clinical Interest

• Anatomical Pathology.
• Bone and soft tissue tumours.
• Pediatric solid tumours.
• Education of specialized training in pathology.
• Molecular diagnostics.

Education

• 1994 – MBBS, University of Melbourne
• 2003 – FRCPA (Royal College of Pathologists Australasia)

Professional / Clinical experience

• Registrar, Department of Histopathology, Monash Medical Centre, Australia 1998.
• Registrar, Department of anatomical pathology, Canberra Hospital, Australia 1998-2000.
• Registrar, Department of anatomical pathology, Royal Prince Alfred, Australia 2001-2003.
• Associate consultant, Department of Pathology, SGH, Singapore 2003-2005.
• Consultant, Department of Pathology, KK hospital, Singapore 2006-2008.
• Consultant & senior consultant, Department of Pathology, NUHS, Singapore 2008-present. Program director of NUHS pathology (2009 to 2013)
• I am very passionate about the research of bone and soft tissue tumours. My general research aim is to characterize the biology of certain sarcoma and bone tumor groups, identifying and developing novel antibodies or proteins that have diagnostic and / or therapeutic implications.
• My current research interest as principal investigator, includes:
a. the analysis of mTOR activity in smooth muscle and soft tissue tumours, especially determining the regulation of mTORC1 activity in smooth muscle tumours and identifying the molecular mechanisms that upregulate mTORC1 activity.
b. Analysis of the WNT signaling pathway in soft tissue and bone tumour which includes testing and validation of specific antibodies that can identify WLS high tumour and identifying a subset of that have high abundance of Wnt secretion proteins.
• Other research activities as collaborator include the study of RUNX3 activity in osteosarcoma and medulloblastoma.
1. Subramaniam MM, Chan JY, Leow PC, Venkateswaran K, Nathan SS, Soong R, Lee VK. Dedifferentiated liposarcoma with unusual kaposiform morphology and whorl formation masquerading As Kaposi's sarcoma: diagnostically challenging case confirmed by cytogenetic and TP53 mutation analysis. J Clin Oncol. 2013 Mar 1;31(7):e101-5. doi: 10.1200/JCO.2012.42.8763. Epub 2013 Jan 14. PubMed PMID: 23319685.
2. Deyrup A*, Lee VK*, Hill CE, Cheuk W, Toh HC, Kesavan S, Chan EW, Weiss SW. "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients." Am J Surg Pathol. 2006; 30(1):75-82. (*Joint first authors with equal contribution).
3. Ong KW, Teo M, Lee V, Ong D, Lee A, Tan CS, Vathsala A, Toh HC. Expression of EBV latent antigens, mammalian target of rapamycin, and tumor suppression genes in EBV-positive smooth muscle tumors: clinical and therapeutic implications. Clin Cancer Res. 2009 Sep 1;15(17):5350-8. Epub 2009 Aug 25.
4. Han Chong Toh, Marissa Teo, Kong Wee Ong, Victor Lee, Errol Chan, Ann SG Lee, A. Vathsala. "Use of sirolimus for epstein-Barr virus-positive smooth muscle tumour". Lancet Oncol. 2006; 7(11):955-7.
5. Subramaniam MM, Ng SB, Seah SB, Anuar D, Soong R, Lee VK. Molecular characterization of dedifferentiated mucoepidermoid carcinoma of the trachea using laser microdissection-based TP53 mutation analysis. Histopathology. 2009 Oct;55(4):472-5.
6. Liang PI, Li CF, Sato Y, Lee VK, Bahrami A, Chuang SS. Ectopic hamartomatous thymoma is distinct from lipomatous pleomorphic adenoma in lacking PLAG1 aberration. Histopathology 2013 Feb;62(3):518-22.
7. Tay CM, Ong CW, Lee VK, Pang B. KIT gene mutation analysis in solid tumours: biology, clincial applications and trends in diagnostic reporting. Pathology. 2013 Feb;45(2):127-37.
8. Lim KH, Ng SB, Lee VK**. "Pulmonary intimal sarcoma presenting as an ascending colonic polyp and mimicking a gastrointestinal stromal tumour." Pathology. 2008 Feb;40(1):85-7.
9. Chew V, Tow C, Teo M, Wong HL, Chan J, Gehring A, Loh M, Bolze A, Quek R, Lee VK, Lee KH, Abastado JP, Toh HC, Nardin A. Inflammatory tumor microenvironment is associated with superior survival in hepatocellular carcinoma patients. J Hepatol. 2010 Mar;52(3):370-9. doi: 10.1016/j.jhep.2009.07.013. Epub 2009 Aug 3. PMID: 19720422
10. Petersson F, Tang A, Cheah A, Barr RJ, VK Lee. Atypical Cellular Unguioblastic Fibroma-A Rare Case With More Atypical Histological Features Than Previously Reported. Am J Dermatopathol. 2010 Jun;32(4):387-91.
1. Lim Huey Jin (research assistant)