Faculty Staff

Thomas Choudary PUTTI

MBBS, MD (path), Dip (American Board)
Associate Professor
Senior Consultant
Department of Pathology

Tel: +65 6772 4012
Email:

Clinical Interest / Subspecialty

• Clinical Director
• Breast pathology
• Fine needle aspirations

Education

• 1985 – M.B; B.S (Osmania University, Hyderabad, India)
• 1989 – M.D, Pathology (Osmania University, India)
• 1997 – Board Certification in Anatomic Pathology (American Board)
• 1998 – Fellowship, Immunopathology (U.S.A)

Professional / Clinical experience

• 1999 – Consultant, Department of Pathology, NUH
• 2000 – Assistant Professor, National University of Singapore
• 2005 – Senior Consultant and Clinical Director, Department of Pathology, NUH
• 2007 – Associate Professor in Pathology, National University of Singapore

Immunohistochemistry

Sentinel lymph nodes

Breast Pathology

Triple negative breast cancer

Tissue Microarray

• NLAM Clinician Scientist "Pitch for Funds" Award of S$10,000 in 2008. The project of the award is entitled "Use of CK19 as A Biological Marker for Sentinel Node Metastasis in Breast Cancer" Dr Reyaz M Singaporewalla in collaboration with Dr Shaik Ahmad Buhari, Department of Surgery (Supervisor), Assoc Prof Thomas Putti (Pathology) and Assoc Professor Manuel Salto-Tellez (Pathology).
• The ethnic difference in incidence of EGFR mutations: Does estrogen play a role? NMRC grant 2008 127,500 for 2 yrs. PI: Tan CM, Collaborators: Sequist L, Soo R, Lynch T, Soong R, Yong YL, Putti TC, Biswas A, Tam J.
• "Dissecting the ERp29-mediated downstream modulators and its oncogenic role in breast tumour progression" BMRC June 2007 (SGD 390,000.00) – Z Daohai and Putti TC (Co-PI).
• RUNX 3 in columnar cell lesions of breast. 2006 NHG grant (S$40,489) – Putti TC (principal investigator), Collaborators – Dr. Lau Quek Choon (ORI), Dr. Ito K (ORI) and Dr. Salto-Tellez M (NUS).
• Methylated genes as predictive markers of recurrent Ductal Carcinoma In Situ. 2006 NHG grant (S$50,000) – Putti TC (principal investigator), Collaborators – Dr. Lau Quek Choon (ORI), Dr. Salto-Tellez M (NUS) and Prof. Saraswathi sukumar (Johns Hopkins, USA).
1. Zheng W, Zhang B, Cai Q, Sung H, Michailidou K, Shi J, Choi JY, Long J, Dennis J, Humphreys MK, Wang Q, Lu W, Gao YT, Li C, Cai H, Park SK, Yoo KY, Noh DY, Han W, Dunning AM, Benitez J, Vincent D, Bacot F, Tessier D, Kim SW, Lee MH, Lee JW, Lee JY, Xiang YB, Zheng Y, Wang W, Ji BT, Matsuo K, Ito H, Iwata H, Tanaka H, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Teo SH, Yip CH, Kang IN, Wong TY, Shen CY, Yu JC, Huang CS, Hou MF, Hartman M, Miao H, Lee SC, Putti TC, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Sangrajrang S, Shen H, Chen K, Wu PE, Ren Z, Haiman CA, Sueta A, Kim MK, Khoo US, Iwasaki M, Pharoah PD, Wen W, Hall P, Shu XO, Easton DF, Kang D. Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet. 2013 Jun 15;22(12):2539-50. doi: 10.1093/hmg/ddt089. Epub 2013 Mar 27. PubMed PMID: 23535825; PubMed Central PMCID: PMC3658167.
2. Karim RZ, O'Toole SA, Scolyer RA, Cooper CL, Chan B, Selinger C, Yu B, Carmalt H, Mak C, Tse GM, Tan PH, Putti TC, Lee CS. Recent insights into the molecular pathogenesis of mammary phyllodes tumours. J Clin Pathol. 2013 Jun;66(6):496-505. doi: 10.1136/jclinpath-2012-201082. Epub 2013 Feb 12. PubMed PMID: 23404800.
3. Tsang JY, Mendoza P, Putti TC, Karim RZ, Scolyer RA, Lee CS, Pang AL, Tse GM. E-cadherin expression in the epithelial components of mammary phyllodes tumors. Hum Pathol. 2012 Dec;43(12):2117-23. doi: 10.1016/j.humpath.2012.03.028. Epub 2012 Jul 21. PubMed PMID: 22820000.
4. Tsang JY, Mendoza P, Lam CC, Yu AM, Putti TC, Karim RZ, Scolyer RA, Lee CS, Tan PH, Tse GM. Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours. Histopathology. 2012 May 9;61(4):667-674. doi: 10.1111/j.1365-2559.2012.04271.x. [Epub ahead of print] PubMed PMID: 22571452.
5. Xiang T, Li L, Yin X, Yuan C, Tan C, Su X, Xiong L, Putti TC, Oberst M, Kelly K, Ren G, Tao Q. The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. PLoS One. 2012;7(1):e29783. doi: 10.1371/journal.pone.0029783. Epub 2012 Jan 18. PubMed PMID: 22279545; PubMed Central PMCID: PMC3261155.
6. Gao D, Bambang IF, Putti TC, Lee YK, Richardson DR, Zhang D. ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPK. Lab Invest. 2012 Feb;92(2):200-13. doi: 10.1038/labinvest.2011.163. Epub 2011 Nov 7. PubMed PMID: 22064321.
7. Petersson F, Hui TS, Loke D, Putti TC. Metastasis of occult prostatic carcinoma to the sphenoid sinus: report of a rare case and a review of the literature. Head Neck Pathol. 2012 Jun;6(2):258-63. doi: 10.1007/s12105-011-0307-6. Epub 2011 Nov 5. Review. PubMed PMID: 22052183; PubMed Central PMCID: PMC3370022.
8. Yan B, Choo SN, Mulyadi P, Srivastava S, Ong CW, Yong KJ, Putti T, Salto-Tellez M, Lim GS. Dual-colour HER2/chromosome 17 chromogenic in situ hybridisation enables accurate assessment of HER2 genomic status in ovarian tumours. J Clin Pathol. 2011 Dec;64(12):1097-101. doi: 10.1136/jclinpath-2011-200082. Epub 2011 Sep 6. PubMed PMID: 21896578.
9. Soh TI, Doshi BK, Putti TC, Ang BW, Aw DC, Cheong WK, Lee SC, Chuah BY. Common bile duct obstruction by intraluminal colorectal metastasis without evidence of liver or intraabdominal nodal metastasis. Int J Colorectal Dis. 2012 Jan;27(1):127-8. doi: 10.1007/s00384-011-1205-9. Epub 2011 Apr 26. PubMed PMID: 21519804.
10. Inaki K, Hillmer AM, Ukil L, Yao F, Woo XY, Vardy LA, Zawack KF, Lee CW, Ariyaratne PN, Chan YS, Desai KV, Bergh J, Hall P, Putti TC, Ong WL, Shahab A, Cacheux-Rataboul V, Karuturi RK, Sung WK, Ruan X, Bourque G, Ruan Y, Liu ET. Transcriptional consequences of genomic structural aberrations in breast cancer. Genome Res. 2011 May;21(5):676-87. doi: 10.1101/gr.113225.110. Epub 2011 Apr 5. PubMed PMID: 21467264; PubMed Central PMCID: PMC3083084.
11. Patheyar V, Venkatesh SK, Siew EP, Consiglieri DT, Putti T. MR imaging features of fibroepithelial ureteral polyp in a patient with duplicated upper urinary tract. Singapore Med J. 2011 Mar;52(3):e45-7. PubMed PMID: 21451914.
12. Therimadasamy A, Peng YP, Putti TC, Wilder-Smith EP. Carpal tunnel syndrome caused by gouty tophus of the flexor tendons of the fingers: sonographic features. J Clin Ultrasound. 2011 Oct;39(8):463-5. doi: 10.1002/jcu.20799. Epub 2011 Mar 15. PubMed PMID: 21412783.
13. Chuah BY, Putti T, Salto-Tellez M, Charlton A, Iau P, Buhari SA, Wong CI, Tan SH, Wong AL, Chan CW, Goh BC, Lee SC. Serial changes in the expression of breast cancer-related proteins in response to neoadjuvant chemotherapy. Ann Oncol. 2011 Aug;22(8):1748-54. doi: 10.1093/annonc/mdq755. Epub 2011 Feb 25. PubMed PMID: 21355070.
14. Subramaniam MM, Chan JY, Omar MF, Ito K, Ito Y, Yeoh KG, Salto-Tellez M, Putti TC. Lack of RUNX3 inactivation in columnar cell lesions of breast. Histopathology. 2010 Oct;57(4):555-63. doi: 10.1111/j.1365-2559.2010.03675.x. PubMed PMID: 20955380.
15. Das K, Lorena PD, Ng LK, Shen L, Lim D, Siow WY, Narasimhan K, Teh M, Choolani M, Putti TC, Salto-Tellez M. Aurora-A expression, hormone receptor status and clinical outcome in hormone related cancers. Pathology. 2010;42(6):540-6. doi: 10.3109/00313025.2010.508789. PubMed PMID: 20854072.
16. Zhang D, Putti TC. Over-expression of ERp29 attenuates doxorubicin-induced cell apoptosis through up-regulation of Hsp27 in breast cancer cells. Exp Cell Res. 2010 Dec 10;316(20):3522-31. doi: 10.1016/j.yexcr.2010.08.014. Epub 2010 Sep 15. PubMed PMID: 20833165.
17. Xiang T, Li L, Fan Y, Jiang Y, Ying Y, Putti TC, Tao Q, Ren G. PLCD1 is a functional tumor suppressor inducing G(2)/M arrest and frequently methylated in breast cancer. Cancer Biol Ther. 2010 Sep 1;10(5):520-7. doi: 10.4161/cbt.10.5.12726. Epub 2010 Sep 21. PubMed PMID: 20657189.
18. Petersson F, Tan PH, Putti TC. Low-grade ductal carcinoma in situ and invasive mammary carcinoma with columnar cell morphology arising in a complex fibroadenoma in continuity with columnar cell change and flat epithelial atypia. Int J Surg Pathol. 2010 Oct;18(5):352-7. doi: 10.1177/1066896910373096. Epub 2010 Jul 18. PubMed PMID: 20643672.
19. Petersson F, Pang B, Thamboo TP, Putti TC. Mucinous cystadenocarcinoma of the breast with amplification of the HER2-gene confirmed by FISH: The first case reported. Hum Pathol. 2010 Jun;41(6):910-3. doi: 10.1016/j.humpath.2009.10.020. Epub 2010 Mar 24. PubMed PMID: 20338619.
20. Roux L, Tutac A, Lomenie N, Balensi D, Racoceanu D, Veillard A, Leow WK, Klossa J, Putti TC. A cognitive virtual microscopic framework for knowledge-based exploration of large microscopic images in breast cancer histopathology. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:3697-702. doi: 10.1109/IEMBS.2009.5334739. PubMed PMID: 19965006.
21. Ong K, Koay ES, Putti TC. Detection of cutaneous HPV types 4 and 24 DNA sequences in breast carcinoma in Singaporean women of Asian ancestry. Pathology. 2009;41(5):436-42. PubMed PMID: 19900082.
22. Das K, Leong DT, Gupta A, Shen L, Putti T, Stein GS, van Wijnen AJ, Salto-Tellez M. Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer. Eur J Cancer. 2009 Sep;45(13):2239-48. doi: 10.1016/j.ejca.2009.06.021. Epub 2009 Jul 24. PubMed PMID: 19632824; PubMed Central PMCID: PMC2733789.
23. Mohd Omar MF, Huang N, Ou K, Yu K, Putti TC, Jikuya H, Ichikawa T, Nishimura O, Tan P, Salto-Tellez M. Molecular-assisted immunohistochemical optimization. Acta Histochem. 2010 Nov;112(6):519-28. doi: 10.1016/j.acthis.2009.05.010. Epub 2009 Jul 22. PubMed PMID: 19628254.
24. Hentze H, Soong PL, Wang ST, Phillips BW, Putti TC, Dunn NR. Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies. Stem Cell Res. 2009 May;2(3):198-210. doi: 10.1016/j.scr.2009.02.002. Epub 2009 Feb 12. PubMed PMID: 19393593.
25. Ang EZ, Nguyen HT, Sim HL, Putti TC, Lim LH. Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells. Mol Cancer Res. 2009 Feb;7(2):266-74. doi: 10.1158/1541-7786.MCR-08-0147. Epub 2009 Feb 10. PubMed PMID: 19208747.
26. Dalle JR, Leow WK, Racoceanu D, Tutac AE, Putti TC. Automatic breast cancer grading of histopathological images. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:3052-5. doi: 10.1109/IEMBS.2008.4649847. PubMed PMID: 19163350.
27. Karim RZ, Scolyer RA, Tse GM, Tan PH, Putti TC, Lee CS. Pathogenic mechanisms in the initiation and progression of mammary phyllodes tumours. Pathology. 2009 Feb;41(2):105-17. doi: 10.1080/00313020802579342. Review. PubMed PMID: 19152185.
28. Poonepalli A, Banerjee B, Ramnarayanan K, Palanisamy N, Putti TC, Hande MP. Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer. Genes Chromosomes Cancer. 2008 Dec;47(12):1098-109. doi: 10.1002/gcc.20608. PubMed PMID: 18720522.
29. Chen Y, Gunawan E, Low KS, Wang SC, Soh CB, Putti TC. Effect of lesion morphology on microwave signature in 2-D ultra-wideband breast imaging. IEEE Trans Biomed Eng. 2008 Aug;55(8):2011-21. doi: 10.1109/TBME.2008.921136. PubMed PMID: 18632364.
30. Das K, Mohd Omar MF, Ong CW, Bin Abdul Rashid S, Peh BK, Putti TC, Tan PH,Chia KS, Teh M, Shah N, Soong R, Salto-Tellez M. TRARESA: a tissue microarray-based hospital system for biomarker validation and discovery. Pathology. 2008 Aug;40(5):441-9. doi: 10.1080/00313020802198101. Review. PubMed PMID: 18604728.
31. Tse GM, Lui PC, Vong JS, Lau KM, Putti TC, Karim R, Scolyer RA, Lee CS, Yu AM, Ng DC, Tse AK, Tan PH. Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. Breast Cancer Res Treat. 2009 Apr;114(3):441-8. doi: 10.1007/s10549-008-0030-5. Epub 2008 Apr 29. PubMed PMID: 18443904.
32. Nathan SS, Lim CT, Chuah BY, Putti TC, Stanley AJ, Wong AS. Renal cell carcinoma bony metastasis treatment. Ann Acad Med Singapore. 2008 Mar;37(3):247-8. PubMed PMID: 18392309.
33. Ou K, Yu K, Kesuma D, Hooi M, Huang N, Chen W, Lee SY, Goh XP, Tan LK, Liu J, Soon SY, Bin Abdul Rashid S, Putti TC, Jikuya H, Ichikawa T, Nishimura O, Salto-Tellez M, Tan P. Novel breast cancer biomarkers identified by integrative proteomic and gene expression mapping. J Proteome Res. 2008 Apr;7(4):1518-28. doi: 10.1021/pr700820g. Epub 2008 Mar 5. PubMed PMID: 18318472.
34. Subramaniam MM, Chan JY, Soong R, Ito K, Ito Y, Yeoh KG, Salto-Tellez M, Putti TC. RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression. Breast Cancer Res Treat. 2009 Jan;113(1):113-21. doi: 10.1007/s10549-008-9917-4. Epub 2008 Feb 7. PubMed PMID: 18256927.
35. Zhang D, Tai LK, Wong LL, Putti TC, Sethi SK, Teh M, Koay ES. Proteomic characterization of differentially expressed proteins in breast cancer: Expression of hnRNP H1, RKIP and GRP78 is strongly associated with HER-2/neu status. Proteomics Clin Appl. 2008 Jan;2(1):99-107. doi: 10.1002/prca.200780099. PubMed PMID: 21136783.
36. Lim CT, Wong AS, Chuah BY, Putti TC, Stanley AJ, Nathan SS. The patella as an unusual site of renal cell carcinoma metastasis. Singapore Med J. 2007 Dec;48(12):e314-9. PubMed PMID: 18043826.
37. Subramaniam MM, Putti TC, Anuar D, Chong PY, Shah N, Salto-Tellez M, Soong R. Clonal characterization of sporadic cribriform-morular variant of papillary thyroid carcinoma by laser microdissection-based APC mutation analysis. Am J Clin Pathol. 2007 Dec;128(6):994-1001. PubMed PMID: 18024325.
38. Tse GM, Tan PH, Lui PC, Putti TC. Spindle cell lesions of the breast—the pathologic differential diagnosis. Breast Cancer Res Treat. 2008 May;109(2):199-207. Epub 2007 Jul 18. Review. PubMed PMID: 17636400.
39. Ong K, Tan KB, Putti TC. Myelolipoma within a non-functional adrenal cortical adenoma. Singapore Med J. 2007 Jul;48(7):e200-2. Review. PubMed PMID: 17609815.
40. Jin H, Wang X, Ying J, Wong AH, Li H, Lee KY, Srivastava G, Chan AT, Yeo W, Ma BB, Putti TC, Lung ML, Shen ZY, Xu LY, Langford C, Tao Q. Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas. Oncogene. 2007 Nov 22;26(53):7490-8. Epub 2007 Jun 4. PubMed PMID: 17546048; PubMed Central PMCID: PMC2875853.
41. Lakshmanan R, Clarke MJ, Putti TC. Diabetic fibrous mastopathy. Singapore Med J. 2007 Jun;48(6):579-81. PubMed PMID: 17538761.
42. Lim SE, Back M, Quek E, Iau P, Putti T, Wong JE. Clinical observations from a breast cancer registry in Asian women. World J Surg. 2007 Jul;31(7):1387-92. Epub 2007 May 18. PubMed PMID: 17510768.
43. Lim YK, Lau PT, Ali AB, Lee SC, Wong JE, Putti TC, Sng JH. Identification of novel BRCA large genomic rearrangements in Singapore Asian breast and ovarian patients with cancer. Clin Genet. 2007 Apr;71(4):331-42. PubMed PMID: 17470134.
44. Ali AB, Iau PT, Putti TC, Sng JH. BRCA1 disease-associated haplotypes in Singapore Malay women with early-onset breast/ovarian cancer. Breast Cancer Res Treat. 2007 Sep;104(3):351-3. Epub 2007 Apr 4. PubMed PMID: 17406974.
45. Thamboo TP, Putti TC. Eye protection during microscopy in histopathology: a simple and effective method. Histopathology. 2007 Jan;50(2):285-7. PubMed PMID: 17222262.
46. Tse GM, Chaiwun B, Lau KM, Scolyer R, Lee CS, Karim RZ, Putti TC, Law BK, Lui PC, Tan PH. Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours. J Clin Pathol. 2007 Sep;60(9):1051-6. Epub 2006 Dec 8. PubMed PMID: 17158636; PubMed Central PMCID: PMC1972415.
47. Ivshina AV, George J, Senko O, Mow B, Putti TC, Smeds J, Lindahl T, Pawitan Y, Hall P, Nordgren H, Wong JE, Liu ET, Bergh J, Kuznetsov VA, Miller LD. Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res. 2006 Nov 1;66(21):10292-301. PubMed PMID: 17079448.
48. Soo RA, Wu J, Aggarwal A, Tao Q, Hsieh W, Putti T, Tan KB, Low JS, Lai YF, Mow B, Hsu S, Loh KS, Tan L, Tan P, Goh BC. Celecoxib reduces microvessel density in patients treated with nasopharyngeal carcinoma and induces changes in gene expression. Ann Oncol. 2006 Nov;17(11):1625-30. Epub 2006 Sep 28. Erratum in: Ann Oncol. 2007 Mar;18(3):611. Soon, W L [corrected to Low, J S W]. PubMed PMID: 17008411.
49. Tan KB, Tan LH, Soo R, Putti TC, Chong SM. Involvement of the appendix and palate by pleomorphic variant mantle cell lymphoma. Leuk Lymphoma. 2006 Aug;47(8):1704-7. PubMed PMID: 16966294.
50. Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito K, Inoue M, Putti TC, Loh M, Ko TK, Huang C, Bhalla KN, Zhu T, Ito Y, Sukumar S. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res. 2006 Jul 1;66(13):6512-20. PubMed PMID: 16818622.
51. Lui PC, Tse GM, Tan PH, Jayaram G, Putti TC, Chaiwun B, Chan NH, Lau PP, Mak KL, Khin AT. Fine-needle aspiration cytology of metaplastic carcinoma of the breast. J Clin Pathol. 2007 May;60(5):529-33. Epub 2006 Jun 23. PubMed PMID: 16798932; PubMed Central PMCID: PMC1994547.
52. Liang X, Lau QC, Salto-Tellez M, Putti TC, Loh M, Sukumar S. Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese. Cancer Biol Ther. 2006 May;5(5):544-8. Epub 2006 May 6. PubMed PMID: 16582596.
53. Teo WY, Tan HK, Goh BC, Putti TC. Postirradiation sarcoma of the sphenoid bone--a case report. Ann Acad Med Singapore. 2006 Feb;35(2):104-7. PubMed PMID: 16565764.
54. Nga ME, Putti TC. Glandular structures in an intraoperative axillary sentinel lymph node biopsy: a diagnostic dilemma. Histopathology. 2006 Mar;48(4):475-7. PubMed PMID: 16487377.
55. Tse GM, Tan PH, Chaiwun B, Putti TC, Lui PC, Tsang AK, Wong FC, Lo AW. p63 is useful in the diagnosis of mammary metaplastic carcinomas. Pathology. 2006 Feb;38(1):16-20. PubMed PMID: 16484002
56. Tse GM, Tan PH, Putti TC, Lui PC, Chaiwun B, Law BK. Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 2006 Oct;59(10):1079-83. Epub 2006 Feb 7. PubMed PMID: 16467167; PubMed Central PMCID: PMC1861754.
57. Rakha EA, Putti TC, Abd El-Rehim DM, Paish C, Green AR, Powe DG, Lee AH, Robertson JF, Ellis IO. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation. J Pathol. 2006 Mar;208(4):495-506. PubMed PMID: 16429394.
58. Lee SC, Lim SG, Soo R, Hsieh WS, Guo JY, Putti T, Tao Q, Soong R, Goh BC. Lack of somatic mutations in EGFR tyrosine kinase domain in hepatocellular and nasopharyngeal carcinoma. Pharmacogenet Genomics. 2006 Jan;16(1):73-4. PubMed PMID: 16344724.
59. Ying J, Li H, Seng TJ, Langford C, Srivastava G, Tsao SW, Putti T, Murray P, Chan AT, Tao Q. Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene. 2006 Feb 16;25(7):1070-80. PubMed PMID: 16247458.
60. Putti TC, Pinder SE, Elston CW, Lee AH, Ellis IO. Breast pathology practice: most common problems in a consultation service. Histopathology. 2005 Nov;47(5):445-57. Review. PubMed PMID: 16241992.
61. Loy AH, Putti TC, Tan LK. Cyclooxygenase-2 expression in Warthin's tumour. J Laryngol Otol. 2005 Jul;119(7):515-8. PubMed PMID: 16175974.
62. Venkatesh SK, Tan LK, Siew EP, Putti TC. Macronodular hepatic tuberculosis associated with portal vein thrombosis and portal hypertension. Australas Radiol. 2005 Aug;49(4):322-4. PubMed PMID: 16026440.
63. Tse GM, Wong FC, Tsang AK, Lee CS, Lui PC, Lo AW, Law BK, Scolyer RA, Karim RZ, Putti TC. Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour. J Clin Pathol. 2005 Jun;58(6):600-4. PubMed PMID: 15917410; PubMed Central PMCID: PMC1770683.
64. Tan KB, Putti TC. Cyclooxygenase 2 expression in nasopharyngeal carcinoma: immunohistochemical findings and potential implications. J Clin Pathol. 2005 May;58(5):535-8. PubMed PMID: 15858127; PubMed Central PMCID: PMC1770665.
65. Soo R, Putti T, Tao Q, Goh BC, Lee KH, Kwok-Seng L, Tan L, Hsieh WS. Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. Arch Otolaryngol Head Neck Surg. 2005 Feb;131(2):147-52. PubMed PMID: 15723947.
66. Salto-Tellez M, Putti TC, Lee CK, Chiu LL, Koay ES. Adenomyoepithelioma of the breast: description of allelic imbalance and microsatellite instability. Histopathology. 2005 Feb;46(2):230-1. PubMed PMID: 15693897.
67. Tse GM, Tsang AK, Putti TC, Scolyer RA, Lui PC, Law BK, Karim RZ, Lee CS. Stromal CD10 expression in mammary fibroadenomas and phyllodes tumours. J Clin Pathol. 2005 Feb;58(2):185-9. PubMed PMID: 15677540; PubMed Central PMCID: PMC1770579.
68. Kew CC, Putti TC, Razvi K. Malignant mesenchymoma arising from a uterine leiomyoma in the menopause. Gynecol Oncol. 2004 Dec;95(3):712-5. PubMed PMID: 15581987.
69. Nga ME, Tan SH, Teh M, Koay ES, Chong SM, Putti TC, Salto-Tellez M. Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence. J Clin Pathol. 2004 Nov;57(11):1222-4. PubMed PMID: 15509690; PubMed Central PMCID: PMC1770480.
70. Tse GM, Lui PC, Lee CS, Kung FY, Scolyer RA, Law BK, Lau TS, Karim R, Putti TC. Stromal expression of vascular endothelial growth factor correlates with tumor grade and microvessel density in mammary phyllodes tumors: a multicenter study of 185 cases. Hum Pathol. 2004 Sep;35(9):1053-7. PubMed PMID: 15343505.
71. Lo TL, Yusoff P, Fong CW, Guo K, McCaw BJ, Phillips WA, Yang H, Wong ES,Leong HF, Zeng Q, Putti TC, Guy GR. The ras/mitogen-activated protein kinasepathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer. Cancer Res. 2004 Sep 1;64(17):6127-36. PubMed PMID: 15342396.
72. Putti TC, El-Rehim DM, Rakha EA, Paish CE, Lee AH, Pinder SE, Ellis IO. Estrogen receptor-negative breast carcinomas: a review of morphology and immunophenotypical analysis. Mod Pathol. 2005 Jan;18(1):26-35. PubMed PMID:15332092.
73. Karim R, Tse G, Putti T, Scolyer R, Lee S. The significance of the Wnt pathway in the pathology of human cancers. Pathology. 2004 Apr;36(2):120-8. Review. PubMed PMID: 15203747.
74. Tse GM, Putti TC, Lui PC, Lo AW, Scolyer RA, Law BK, Karim R, Lee CS. Increased c-kit (CD117) expression in malignant mammary phyllodes tumors. Mod Pathol. 2004 Jul;17(7):827-31. PubMed PMID: 15044924.
75. Putti TC, Teh M, Lee YS. Biological behavior of keratoacanthoma and squamous cell carcinoma: telomerase activity and COX-2 as potential markers. Mod Pathol. 2004 Apr;17(4):468-75. PubMed PMID: 14976535.
76. Tan KB, Yong WP, Putti TC. Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. Histopathology. 2004 Jan;44(1):24-8. PubMed PMID: 14717665.
77. Leong JL, Loh KS, Putti TC, Goh BC, Tan LK. Epidermal growth factor receptor in undifferentiated carcinoma of the nasopharynx. Laryngoscope. 2004 Jan;114(1):153-7. PubMed PMID: 14710013.
78. Tan KB, Premasiri MK, Putti TC. Uterine malignant mixed müllerian tumour with pilomatrixoma-like areas. Pathology. 2003 Dec;35(6):532-3. PubMed PMID: 14660107.
79. Tse GM, Lui PC, Scolyer RA, Putti TC, Kung FY, Law BK, Lau TS, Lee CS. Tumour angiogenesis and p53 protein expression in mammary phyllodes tumors. Mod Pathol. 2003 Oct;16(10):1007-13. PubMed PMID: 14559983.
80. Zhang D, Salto-Tellez M, Do E, Putti TC, Koay ES. Evaluation of HER-2/neu oncogene status in breast tumors on tissue microarrays. Hum Pathol. 2003 Apr;34(4):362-8. PubMed PMID: 12733117.
81. Wu M, Putti TC, Bhuiya TA. Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region. Appl Immunohistochem Mol Morphol. 2002 Dec;10(4):351-6. PubMed PMID: 12607604.
82. Zhang D, Salto-Tellez M, Putti TC, Do E, Koay ES. Reliability of tissue microarrays in detecting protein expression and gene amplification in breast cancer. Mod Pathol. 2003 Jan;16(1):79-84. PubMed PMID: 12527717.
83. Tan KB, Lee HY, Putti TC. Ductal carcinoma in situ of the breast in Singapore: recent trends and clinical implications. ANZ J Surg. 2002 Nov;72(11):793-7. PubMed PMID: 12437689.
84. Tse GM, Lee CS, Kung FY, Scolyer RA, Law BK, Lau TS, Putti TC. Hormonal receptors expression in epithelial cells of mammary phyllodes tumors correlates with pathologic grade of the tumor: a multicenter study of 143 cases. Am J Clin Pathol. 2002 Oct;118(4):522-6. PubMed PMID: 12375638.
85. Putti TC, To KF, Hsu HC, Chan AT, Lai GM, Tse G, Lee YS, Whang-Peng J, Millward M, Lin L, Lin X, Lee CS. Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicenter immunohistochemical study in the Asia-Pacific region. Histopathology. 2002 Aug;41(2):144-51. PubMed PMID: 12147092.
86. Tse GM, Putti TC, Kung FY, Scolyer RA, Law BK, Lau TS, Lee CS. Increased p53 protein expression in malignant mammary phyllodes tumors. Mod Pathol. 2002 Jul;15(7):734-40. Erratum in: Mod Pathol. 2002 Sep;15(9):1010. PubMed PMID:12118111.
87. Putti TC, Bhuiya TA. Mixed columnar cell and tall cell variant of papillary carcinoma of thyroid: a case report and review of the literature. Pathology. 2000Nov;32(4):286-9. Review. PubMed PMID: 11186427.
88. Choi Y, Putti T, Win K, Hu Y, Remy P, Bloom A. Correlation of viral RNA,alanine aminotransferase, and histopathology in hepatitis C virus-associated hepatitis. Mol Diagn. 1999 Sep;4(3):251-4. PubMed PMID: 10553026.
89. Thirumala SD, Putti TC, Medalie NS, Wasserman PG. Skeletal metastases from a granulosa-cell tumor of the ovary: report of a case diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 1998 Nov;19(5):375-7. PubMed PMID:9812234.
90. Putti TC, Bhuiya TA, Wasserman PG. Fine needle aspiration cytology of mixed tall and columnar cell papillary carcinoma of the thyroid. A case report. ActaCytol. 1998 Mar-Apr;42(2):387-90. PubMed PMID: 9568142.
91. Putti TC, Kahn LB, Aprin H. Periosteal chondrosarcoma: a case report and review of the literature. Arch Pathol Lab Med. 1997 Jan;121(1):70-4. Review. PubMed PMID: 9111097