Faculty Staff
Brendan Pang Nghee Kheem
MBBS, FRCPath
Clinical Assistant Professor
Consultant, Department of Pathology, National University Hospital
Clinical Assistant Professor, Clinician-Educator Tract, Department of Pathology, Yong Loo Lin School of Medicine, National University Singapore
Laboratory (Section) Director, Diagnostic Molecular Oncology Centre,
Department of Pathology, National University Health System
Principal Associate, Cancer Science Institute, NUS
Tel: +65 9843 0638
Email:
CV: http://www.ncis.com.sg/patient-and-visitors/find-a-doctor/dr-brendan-pang.html
Clinical Interest
| • | Molecular cytopathology |
| • | Diagnostic molecular pathology |
Subspecialty
| • | Biomarker Discovery and Validation |
| • | Molecular Anatomic Pathology |
Education
| • | 2003 – MBBS (NUS), Singapore |
| • | 2009 – FRCPath, United Kingdom |
Professional / Clinical experience
| • | Consultant, Department of Pathology, National University Hospital 2012 – present |
| • | Laboratory Section Director, Diagnostic Molecular Oncology Centre, Department of Pathology, National University Health System 2011 – present |
| • | Fellowship in Molecular Anatomic Pathology (University of Pittsburgh Medical Center) 2010-2011 |
| • | Associate Consultant, Department of Pathology, National University Hospital 2009 – 2011 |
| • | Registrar, Department of Pathology, National University Hospital 2006 – 2009 |
Dr Brendan Pang obtained the FRCPath (UK) and qualified as a histopathologist. He then trained in the Diagnostic Molecular Oncology Centre (DMOC), a College of American Pathologists (CAP) accredited molecular diagnostic laboratory under the mentorship of Professor Manuel Salto-Tellez. He furthered his training in molecular pathology in 2010 as a visiting scholar at the University of Pittsburgh Medical Centre' (UPMC) Molecular Anatomic Pathology (MAP) laboratory, Presbyterian Hospital, under Dr Marina Nikiforova, chair-elect of the solid tumours sub-division of the Association of Molecular pathology (AMP) and returned to Singapore as the Laboratory Section Director of DMOC in 2011. He was appointed as Principal Associate at the Cancer Science Institute (CSI) in 2013 and has research collaborations with the Genome Institute of Singapore (GIS) and other PIs from the Yong Loo Lin School of Medicine. His research interests lie in the development of novel biomarker assays using molecular platforms.
Selected Publications
| 1. | Pang NK, Nga ME, Chin SY, Ismail TM, Lim GL, Soong R, Salto-Tellez M. KRAS and BRAF mutation analysis can be reliably performed on aspirated cytological specimens of metastatic colorectal carcinoma. Cytopathology. 2011 Dec;22(6):358-64 |
| 2. | Pang NK, Chin SY, Nga ME, Chang AR, Ismail TM, Omar SS, Charlton A, Salto-Tellez M. Comparative validation of c-kit exon 11 mutation analysis on cytology samples and corresponding surgical resections of gastrointestinal stromal tumours. Cytopathology. 2009 Oct;20(5):297-303. |
| 3. | Pang B, Matthias D, Ong CW, Dhewar AN, Gupta S, Lim GL, Nga ME, Seet JE, Qasim A, Chin TM, Soo R, Soong R, Salto-Tellez M.The positive impact of cytological specimens for EGFR mutation testing in non-small cell lung cancer: a single South East Asian laboratory's analysis of 670 cases.Cytopathology. 2012 Aug; 23(4):229-36. |
| 4. | Pang B, Ong CW, Chong ML, Muliana-Ismail T, Soong R, Salto-Tellez M.KRAS mutation analysis in a complex molecular diagnostic referral practice: the need for test redundancy Pathology. 2012 Dec;44(7):655-7. doi: 10.1097/PAT.0b013e328359d5a |
| 5. | Tay CM, Ong CW, Lee VK, Pang B. KIT gene mutation analysis in solid tumours: biology, clinical applications and trends in diagnostic reporting.Pathology. 2013 Feb;45(2):127-37. doi: 10.1097/PAT.0b013e32835c7645 |
| 6. | Pang B, DursoMB, Hamilton RL, Nikiforova MN A Novel COLD-PCR/FMCA Assay Enhances the Detection of Low-abundance IDH1 Mutations in Gliomas. DiagnMolPathol. 2013 Mar;22(1):28-34. doi: 10.1097/PDM.0b013e31826c7ff8. PMID: 23370430 |
| 7. | van Grieken NC, Aoyma T, Chambers PA, Bottomley D, Ward LC, Inam I, Buffart TE, Das K, Lim T, Pang B, Zhang SL, Tan IB, Carvalho B, Heideman DA, Miyagi Y, Kameda Y, Arai T, Meijer GA, suburaya A, Tan P, Yoshikawa T, Grabsch HI.KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study. Br J Cancer. 2013 Mar 19. doi: 10.1038/bjc.2013.109. [Epub ahead of print] |
| 8. | Nagarajan N, Bertrand D, Hillmer AM, Zang ZJ, Yao F, Jacques PE, Teo AS, Cutcutache I, Zhang Z, Lee WH, Sia YY, Gao S, Ariyaratne PN, Ho A, Woo XY, Veeravali L, Ong CK, Deng N, Desai KV, Khor CC, Hibberd ML, Shahab A, Rao J, Wu M, Teh M, Zhu F, Chin SY, Pang B, So JB, Bourque G, Soong R, Sung WK, Tean Teh B, Rozen S, Ruan X, Yeoh KG, Tan PB, Ruan Y. Whole-genome reconstruction and mutational signatures in gastric cancer.Genome Biol. 2012 Dec 13;13(12):R115. [Epub ahead of print] PMID: 23237666 |
| 9. | Shah N, Pang B, Yeoh KG, Thorn S, Chen CS, Lilly MB, Salto-Tellez M. Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal. European Journal of Cancer 2008 Oct; 44(15):2144-51 |
| 10. | Lim GH, Roslani AC, Pang B, Bih-Shiou CT Cholesterol atheroembolism of the colon can mimic the endoscopic features of pseudomembranous colitis Laparosc Endosc Percutan Tech. 2008 Dec;18(6):616-8 |
| 1. | Lee Chi Kuen |
| 2. | Ng Lai Kuan |
| 3. | Natarajan Venkateswaran |
| 4. | Wong Ziwei |
| 5. | Sandy Kim Lay Gek |