Faculty Staff

Aileen Wee

MBBS, FRCPath, FRCPA
Professor of Pathology
Senior Consultant,
Department of Pathology

Member, American Association for the Study of Liver Disease (AASLD)
Member, Laennec Liver Pathology Society

Tel: +65 6772 4305
Email:

Clinical Interest / Subspecialty

• Hepatobiliary pathology, including transplant pathology
• Fine needle aspiration cytology of hepatobiliary tract

Education

• 1975 – MBBS, University of Singapore, Singapore
• 1981 – FRCPA, Royal College of Pathologists of Australasia
• 1982 – MRCPath, Royal College of Pathologists, United Kingdom
• 2005 – FRCPath, Royal College of Pathologists, United Kingdom

Professional / Clinical experience

• Professor, Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, 1999 – present
• Associate Professor, Department of Pathology, National University of Singapore, 1991 – 1999
• Senior Lecturer, Department of Pathology, National University of Singapore, 1985 – 90
• Lecturer, Department of Pathology, National University of Singapore, 1976 – 84
• Fine needle aspiration cytology of liver mass lesions can be a very challenging diagnostic area, especially in regions where chronic liver disease and, thus, hepatocellular nodular lesions of diverse nature abound. My interest in this area has culminated in a book addressing the cytohistological algorithmic approach to the diagnosis of small tissue samples from focal liver lesions.
• In chronic liver disease, assessment of hepatic fibrosis is important for the evaluation of efficacy of antiviral and antifibrotic therapies. Accurate computerized morphometric analysis and staging of hepatic fibrosis with aim to give a better reflection of the hemodynamic and functional status of the diseased liver are areas I am working on with my collaborators.

BOOK CHAPTERS/BOOKS

1. Liver Cytohistology in the series "Cytohistology of Small Tissue Samples", Papanicolaou Society of Cytopathology in association with Cambridge University Press (in press)
2. Odze's Surgical Pathology of GIT, Liver, Biliary Tract and Pancreas (in press)
3. MacSween's Pathology of the Liver, 6th edition, Churchill Livingstone, 2012
4. WHO Classification of Tumours of the Digestive System, IARC: Lyon, 2010
5. Handbook of Immunohistochemistry and in situ hybridization of Human Carcinomas, Volume 3. Molecular Genetics, Liver Carcinoma, and Pancreatic Carcinoma. London: Elsevier, 2005
6. Fine needle aspiration cytology of the liver. Diagnostic Algorithms. A Southeast Asian perspective. Bangkok: Year Book Publisher, 2004

JOURNALS

1. Balabaud C, Al-Rabih WR, Chen PJ, Evason K, Ferrell L, Hernandez-Prera JC, Huang SF, Longerich T, Park YN, Quaglia A, Schirmacher P, Sempoux C, Thung SN, Torbenson M, Wee A, Yeh MM, Yeh SH, Le Bail B, Zucman-Rossi J, Bioulac-Sage P. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. Int J Hepatol. 2013; 2013: 268625.
2. Xu S, Tai D, Wee A, Welsch R, So P, Yu H, Rajapakse J. Automated scoring of liver fibrosis through combined features from different collagen groups. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011: 4503-6.
3. Wee A. Fine needle aspiration biopsy of hepatocellular carcinoma and hepatocellular nodular lesions: role, controversies and approach to diagnosis. Cytopathology. 2011; 22: 287-305.
4. Wee A. Fine-needle aspiration biopsy of hepatocellular carcinoma and related hepatocellular nodular lesions in cirrhosis: controversies, challenges, and expectations. Patholog Res Int. 2011; 2011: 587936.
5. Tai DC, Tan N, Xu S, Kang CH, Chia SM, Cheng CL, Wee A, Wei CL, Raja AM, Xiao G, Chang S, Rajapakse JC, So PT, Tang HH, Chen CS, Yu H. Fibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy. J Biomed Opt. 2009; 14(4): 044013.
6. Wee A. Diagnostic utility of immunohistochemistry in hepatocellular carcinoma, its variants and their mimics. Appl Immunohistochem Mol Morphol. 2006; 14(3): 266-72.
7. Lim LG, Cheng CL, Wee A, Lim SG, Lee YM, Sutedja DS, Da Costa M, Prabhakaran K, Wai CT. Prevalence and clinical associations of posttransplant fatty liver disease. Liver Int. 2007; 27(1): 76-80.
8. Wee A. Fine needle aspiration biopsy of the liver: Algorithmic approach and current issues in the diagnosis of hepatocellular carcinoma. Cytojournal. 2005; 8; 2:7.
9. Wee A, Ludwig J, Coffey RJ Jr, LaRusso NF, Wiesner RH. Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. Hum Pathol. 1985; 16(7): 719-26.
10. Wee A, Ludwig J. Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts? Ann Intern Med. 1985; 102(5): 581-7.