Cardiovascular Diseases

Cardiovascular diseases continue to be a major cause of morbidity and premature mortality, and account for a disproportionate percentage of healthcare costs.

There is a need for healthcare service delivery platforms that simultaneously reduce healthcare burden and increase effective self-management at home and in the community. By leveraging on technological innovation, the Chronic Illness and Long-term Care research in NUS Nursing endeavors to spearhead the development of technology-enhanced secondary prevention delivery platforms that revolutionise cardiovascular disease management – in a way that is accessible, flexible, and sensitive to the needs of patients and their caregivers.

Core Members: Dr Catherine DONG, Dr Ying JIANG, Dr Wilson TAM, Prof Wenru WANG

Publications

  • Chen NYC, Tan MYL, Xu J, Zuo L, Dong Y.. VasCog Screen test: sensitive in detecting cognitive impairment in patients who had a stroke or with heart failure. Stroke Vasc Neurol. 2024 Apr 22:svn-2023-002701. doi: 10.1136/svn-2023-002701. Online ahead of print.. 10.1136/svn-2023-002701

  • Li J, Fong DYT, Lok KYW, Wong JYH, Man Ho M, Choi EPH, Pandian V, Davidson PM, Duan W, Tarrant M, Lee JJ, Lin CC, Akingbade O, Alabdulwahhab KM, Ahmad MS, Alboraie M, Alzahrani MA, Bilimale AS, Boonpatcharanon S, Byiringiro S, Hasan MKC, Schettini LC, Corzo W, De Leon JM, De Leon AS, Deek H, Efficace F, El Nayal MA, El-Raey F, Ensaldo-Carrasco E, Escotorin P, Fadodun OA, Fawole IO, Goh YS, Irawan D, Khan NE, Koirala B, Krishna A, Kwok C, Le TT, Leal DG, Lezana-Fernández MÁ, Manirambona E, Mantoani LC, Meneses-González F, Mohamed IE, Mukeshimana M, Nguyen CTM, Nguyen HTT, Nguyen KT, Nguyen ST, Nurumal MS, Nzabonimana A, Omer NAMA, Ogungbe O, Poon ACY, Reséndiz-Rodriguez A, Puang-Ngern B, Sagun CG, Shaik RA, Shankar NG, Sommer K, Toro E, Tran HTH, Urgel EL, Uwiringiyimana E, Vanichbuncha T, Youssef N.. Key lifestyles and health outcomes across 16 prevalent chronic diseases: A network analysis of an international observational study. J Glob Health. 2024 Apr 12;14:04068. doi: 10.7189/jogh-14-04068.. 10.7189/jogh-14-04068

  • Soh PQP, Wong WHT, Roy T, Tam WWS.. Effectiveness of non-pharmacological interventions in improving sleep quality after cardiac surgery: A systematic review and meta-analysis. J Clin Nurs. 2024 Jun;33(6):2084-2098. doi: 10.1111/jocn.17115. Epub 2024 Mar 13.. 10.1111/jocn.17115

  • Yan T, Yu H, Li T, Dong Y.. Mechanisms of Cardiovascular Toxicities Induced by Cancer Therapies and Promising Biomarkers for Their Prediction: A Scoping Review. Heart Lung Circ. 2024 Jan 18:S1443-9506(23)04464-5. doi: 10.1016/j.hlc.2023.12.006. Online ahead of print.. 10.1016/j.hlc.2023.12.006

  • Zuo L, Dong Y, Liao X, Hu Y, Pan Y, Yan H, Wang X, Zhao X, Wang Y, Seet RCS, Wang Y, Li Z.. Low HALP (Hemoglobin, Albumin, Lymphocyte, and Platelet) Score Increases the Risk of Post-Stroke Cognitive Impairment: A Multicenter Cohort Study. Clin Interv Aging. 2024 Jan 10;19:81-92. doi: 10.2147/CIA.S432885. eCollection 2024.. 10.2147/CIA.S432885

  • Woo B, Huynh T, Tang A, Bui N, Nguyen G, Tam W.. Transforming nursing with large language models: from concept to practice. Eur J Cardiovasc Nurs. 2024 Jan 5:zvad120. doi: 10.1093/eurjcn/zvad120. Online ahead of print.. 10.1093/eurjcn/zvad120

  • Teo YH, Yong CL, Ou YH, Tam WW, Teo YN, Koo CY, Kojodjojo P, Lee CH.. Obstructive sleep apnea and temporal changes in cardiac repolarization in patients undergoing coronary artery bypass grafting. J Clin Sleep Med. 2024 Jan 1;20(1):49-55. doi: 10.5664/jcsm.10786.. 10.5664/jcsm.10786

  • Woo BFY, Ng WM, Tan IF, Zhou W.. Practice patterns, role and impact of advanced practice nurses in stroke care: A mixed-methods systematic review. J Clin Nurs. 2024 Apr;33(4):1306-1319. doi: 10.1111/jocn.16970. Epub 2023 Dec 22.. 10.1111/jocn.16970

  • Cai JS, Tan JXJ, Ignacio J.. The experiences and needs of people with dysvascular lower extremity amputations: a qualitative systematic review and meta-synthesis. Disabil Rehabil. 2023 Dec 7:1-14. doi: 10.1080/09638288.2023.2291552. Online ahead of print.. 10.1080/09638288.2023.2291552

  • Zhou Y, Zhang X, Gao Y, Alvi RM, Erqou S, Chen Y, Wang H, Wang W, Li X, Zanni MV, Neilan TG, Vermund SH, Qian HZ, Qian F.. Risk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis. J Infect Public Health. 2024 Jan;17(1):70-75. doi: 10.1016/j.jiph.2023.11.004. Epub 2023 Nov 7.. 10.1016/j.jiph.2023.11.004

  • Tham XC, Phua VJX, Ho EKY, Yan T, Chen NYC, Zuo L, Thompson CL, Dong Y.. Train-your-brain program to reduce depression, anxiety, and stress in stroke survivors: a pilot community-based cognitive intervention study. Front Neurol. 2023 Aug 10;14:1163094. doi: 10.3389/fneur.2023.1163094. eCollection 2023.. 10.3389/fneur.2023.1163094

  • Jiang Y, Zhang C, Hong J, Tam WWS, Ramachandran HJ, Wang W.. Relationships of person-related, problem-related, and environment-related factors to self-care behaviours and the mediating role of self-confidence among patients with heart failure: Cross-sectional analysis of structural equation modelling. Int J Nurs Stud. 2023 Nov;147:104590. doi: 10.1016/j.ijnurstu.2023.104590. Epub 2023 Aug 21.. 10.1016/j.ijnurstu.2023.104590

  • Chen NYC, Dong Y, Kua ZZJ.. Addressing mood and fatigue in return-to-work programmes after stroke: a systematic review. Front Neurol. 2023 Aug 22;14:1145705. doi: 10.3389/fneur.2023.1145705. eCollection 2023.. 10.3389/fneur.2023.1145705

  • Zuo L, Dong Y, Pan Y, Yan H, Meng X, Li H, Zhao X, Wang Y, Wang Y, Liao X.. Impact of Serum Cystatin C Level on Long-Term Cognitive Impairment After Acute Ischemic Stroke and Transient Ischemic Attack. Neuropsychiatr Dis Treat. 2023 Jul 5;19:1543-1554. doi: 10.2147/NDT.S412825. eCollection 2023.. 10.2147/NDT.S412825

  • Woo BF, Hendriks JM, Tam W, Lim TW.. Assessment of the general public's knowledge of atrial fibrillation through social media: a cross-sectional study. BMC Nurs. 2023 Jun 16;22(1):207. doi: 10.1186/s12912-023-01378-7.. 10.1186/s12912-023-01378-7

  • Ni RSS, Mohamed Raffi HQ, Dong Y.. The pathophysiology of cognitive impairment in individuals with heart failure: a systematic review. Front Cardiovasc Med. 2023 May 23;10:1181979. doi: 10.3389/fcvm.2023.1181979. eCollection 2023.. 10.3389/fcvm.2023.1181979

  • Zhang S, Zhang N, Wang S, Hong J, Li F, Guo H, Lv Z, Wang Y, Wang W, Wu W.. Circadian rhythms and sleep quality among undergraduate students in China: The mediating role of health-promoting lifestyle behaviours. J Affect Disord. 2023 Jul 15;333:225-232. doi: 10.1016/j.jad.2023.04.077. Epub 2023 Apr 21.. 10.1016/j.jad.2023.04.077

  • Toh ZA, Cheng LJ, Wu XV, De Silva DA, Oh HX, Ng SX, He HG, Pikkarainen M.. Positive airway pressure therapy for post-stroke sleep disordered breathing: a systematic review, meta-analysis and meta-regression. Eur Respir Rev. 2023 Mar 8;32(167):220169. doi: 10.1183/16000617.0169-2022. Print 2023 Mar 31.. 10.1183/16000617.0169-2022

  • Zheng Y, Lim MJR, Tan BY, Chan BPL, Paliwal P, Jonathan OJY, Bharatendu C, Chan ACY, Yeo LLL, Vijayan J, Hong CS, Chee YH, Wong LYH, Chen J, Chong VYF, Dong Y, Tan CH, Sunny S, Teoh HL, Sinha AK, Sharma VK.. Role of plaque inflammation in symptomatic carotid stenosis. Front Neurol. 2023 Jan 24;14:1086465. doi: 10.3389/fneur.2023.1086465. eCollection 2023.. 10.3389/fneur.2023.1086465

  • Ramachandran HJ, Seah ACW, Teo JYC, Yeo TJ, Wang W.. East meets West: making the case for traditional Chinese exercises in the management of heart disease. Eur J Cardiovasc Nurs. 2023 Sep 5;22(6):e47-e48. doi: 10.1093/eurjcn/zvad006.. 10.1093/eurjcn/zvad006

  • Wang LYT, Lua JYH, Chan CXC, Ong RLL, Wee CF, Woo BFY.. Health information needs and dissemination methods for individuals living with ischemic heart disease: A systematic review. Patient Educ Couns. 2023 Mar;108:107594. doi: 10.1016/j.pec.2022.107594. Epub 2022 Dec 19.. 10.1016/j.pec.2022.107594

  • Tang SWY, Mai AS, Chew NWS, Tam WWS, Tan DS.. The clinical impact of anti-hypertensive treatment drug-gene pairs in the asian population: a systematic review of publications in the past decade. J Hum Hypertens. 2023 Mar;37(3):170-180. doi: 10.1038/s41371-022-00765-y. Epub 2022 Oct 27.. 10.1038/s41371-022-00765-y

  • Woo BFY, Bulto LN, Hendriks JML, Lim TW, Tam WWS.. The information needs of patients with atrial fibrillation: A scoping review. J Clin Nurs. 2023 May;32(9-10):1521-1533. doi: 10.1111/jocn.15993. Epub 2021 Aug 12.. 10.1111/jocn.15993

  • Chan, G.F.K., Jiang, Y., Choo, W.T., Ramachandran, H.J., Lin, Y., Wang, W. (2022). Effect of exergaming on functional outcomes in people with chronic stroke: A systematic review and meta-analysis. Journal of Advanced Nursing, 78(4), 929-946. doi: 10.1111/jan.15125

  • Choo, W. T., Jiang, Y., Chan, K. G., Ramachandran, H. J., Teo, J. Y., Seah, C. W. & Wang, W.(2022). Effectiveness of caregiver-mediated exercise interventions on activities of daily living, anxiety and depression post-stroke rehabilitation: A systematic review and meta-analysis. Journal of Advanced Nursing, 78, 1870– 1882. https://doi.org/10.1111/jan.15239

  • Ramachandran, H.J., Jiang, Y., Tam, W.SW.S., Yeo, T.J. & Wang, W. (2022). Effectiveness of home-based cardiac telerehabilitation as an alternative to phase 2 centre-based cardiac rehabilitation: A systematic review and meta-analysis. European Journal of Preventive Cardiology, 29(7), 1017-1043. https://doi-org.libproxy1.nus.edu.sg/10.1093/eurjpc/zwab106

  • Ramachandran, H.J., Jiang, Y., Teo, J.Y.C., Yeo, T.J. & Wang, W. (2022). Technology acceptance of home-based cardiac telerehabilitation programs in patients with coronary heart disease: Systematic scoping review. Journal of Medical Internet Research, 24(1):e34657. https://www.jmir.org/2022/1/e34657/

  • Chew, H., Sim, K., Choi, K. C., & Chair, S. Y. (2021). Effectiveness of a nurse-led temporal self-regulation theory-based program on heart failure self-care: A randomized controlled trial. International journal of nursing studies, 115, 103872. https://doi.org/10.1016/j.ijnurstu.2021.103872

  • Jiang, Y., Koh, K. W. L., Ramachandran, H. J., Nguyen, H. D., Tay, Y. K., Shorey, S., & Wang, W. (2021). The effectiveness of a nurse-led home-based heart failure self-management programme (the HOM-HEMP) for patients with chronic heart failure: a three-arm stratified randomized controlled trial. International Journal of Nursing Studies, 122, 104026.

  • Jiang, Y., Koh, K. W. L., Ramachandran, H. J., Tay, Y. K., Wu, V. X., Shorey, S., & Wang, W. (2021). Patients’ Experiences of a Nurse-Led, Home-Based Heart Failure Self-management Program: Findings From a Qualitative Process Evaluation. Journal of Medical Internet Research, 23(4), e28216.

  • Kanie, T., Mizuno, A., Takaoka, Y., Suzuki, T., Yoneoka, D., Nishikawa, Y., Tam, W., Morze, J., Rynkiewicz, A., Xin, Y., Wu, O., Providencia, R., & Kwong, J. S. (2021). Dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter-2 inhibitors for people with cardiovascular disease: a network meta-analysis. The Cochrane database of systematic reviews, 10(10), CD013650. https://doi.org/10.1002/14651858.CD013650.pub2

  • Li, Y., Chien, W.-T., Zhu, B.Q., He, H.G., & Bressington, D. (2021). Predictors of Self‐Efficacy Among People with spinal cord injury during inpatient rehabilitation: a cross‐sectional study. Journal of Nursing Scholarship, 53(2), 218-226.  doi: 10.1111/jnu.12632. 

  • Ng, S. X., Wang, W., Shen, Q., Toh, Z. A., & He, H. G. (2021). The effectiveness of preoperative education interventions on improving perioperative outcomes of adult patients undergoing cardiac surgery: a systematic review and meta-analysis. European journal of cardiovascular nursing, zvab123. Advance online publication. https://doi.org/10.1093/eurjcn/zvab123

  • Woo, B., Bulto, L. N., Hendriks, J., Lim, T. W., & Tam, W. (2021). The information needs of patients with atrial fibrillation: A scoping review. Journal of clinical nursing, 10.1111/jocn.15993. Advance online publication. https://doi.org/10.1111/jocn.15993

  • Chair, S. Y., Cheng, H. Y., Chew, H., Zang, Y. L., Siow, E., & Cao, X. (2020). Leisure-Time Physical Activity and Depressive Symptoms Among Patients With Coronary Heart Disease: The Mediating Role of Physical Activity Self-Efficacy. Worldviews on evidence-based nursing, 17(2), 144–150. https://doi.org/10.1111/wvn.12425

  • Chew, H., Sim, K., Choi, K. C., & Chair, S. Y. (2020). Relationship between self-care adherence, time perspective, readiness to change and executive function in patients with heart failure. Journal of behavioral medicine, 43(4), 1–11. https://doi.org/10.1007/s10865-019-00080-x

  • Jiang, W., Feng, M., Gao, C., Li, J., Gao, R., & Wang, W. (2020). Effect of a nurse-led individualized self-management program for Chinese patients with acute myocardial infarction undergoing percutaneous coronary intervention. European Journal of Cardiovascular Nursing, 19(4), 320-329. https://doi.org/10.1177/1474515119889197

  • Jiang, Y., Shorey, S., Nguyen, H.D., Wu, V. X., Lee, C.Y., Yang, L.F., Koh, W. L. K., & Wang W.* (2020). The development and pilot study of a nurse-led HOMe-based HEart Failure Self-Management Programme (the HOM-HEMP) for patients with chronic heart failure, following medical research council guidelines. European Journal of Cardiovascular Nursing, 19(3), 212-222. http://doi.org/10.1177/1474515119872853

  • Koo, C. Y., Aung, A. T., Chen, Z., Kristanto, W., Sim, H. W., Tam, W. W., Gochuico, C. F., Tan, K. A., Kang, G. S., Sorokin, V., Ong, P., Kojodjojo, P., Richards, A. M., Tan, H. C., Kofidis, T., & Lee, C. H. (2020). Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting. Heart (British Cardiac Society), 106(19), 1495–1502. https://doi.org/10.1136/heartjnl-2019-316118

  • Ling, R. Z. Q., Jiao, N., Hassan, N. B., He, H.G., & Wang, W. (2020). Adherence to diet and medication and the associated factors among patient with chronic heart failure in a multi-ethnic society. Heart & Lung, 49(2), 144-150. doi:10.1016/j.hrtlng.2019.11.003.

  • Sua, Y. S., Jiang, Y., Thompson, D. R., & Wang, W. (2020). Effectiveness of mobile phone-based self-management interventions for medication adherence and change in blood pressure in patients with coronary heart disease: A systematic review and meta-analysis. European Journal of Cardiovascular Nursing, 19(3), 192-200. http://doi.org/10.1177/1474515119895678

  • Chew, H., Cheng, H. Y., & Chair, S. Y. (2019). The suitability of motivational interviewing versus cognitive behavioural interventions on improving self-care in patients with heart failure: A literature review and discussion paper. Applied nursing research : ANR, 45, 17–22. https://doi.org/10.1016/j.apnr.2018.11.006

  • Chew, H., Sim, K., Cao, X., & Chair, S. Y. (2019). Motivation, Challenges and Self-Regulation in Heart Failure Self-Care: a Theory-Driven Qualitative Study. International journal of behavioral medicine, 26(5), 474–485. https://doi.org/10.1007/s12529-019-09798-z

  • Dong, Y., Teo, S. Y., Kang, K., Tan, M., Ling, L. H., Yeo, P., Sim, D., Jaufeerally, F., Leong, K., Ong, H. Y., Soon, D., Lee, S., Loh, S. Y., Tan, R. S., Chan, S. P., Richards, A. M., & Lam, C. (2019). Cognitive impairment in Asian patients with heart failure: prevalence, biomarkers, clinical correlates, and outcomes. European journal of heart failure, 21(5), 688–690. https://doi.org/10.1002/ejhf.1442

  • Gouw, X.H.V., Jiang, Y., Seah, B., He, H.G., Hong, J.F., & Wang, W. (2019). Effectiveness of internal Qigong on quality of life, depressive symptoms and self-efficacy among community-dwelling older adults with chronic disease: A systematic review and meta-analysis. International Journal of Nursing Studies, 99, 103378. doi: 10.1016/j.ijnurstu.2019.06.009.

  • Jiang, Y., Jiao, N., Nguyen, H. D., Lopez, V., Wu, V. X., Kowitlawakul, Y., Poo, D., & Wang, W. (2019). Effect of a mHealth programme on coronary heart disease prevention among working population in Singapore: A single group pretest-post-test design. Journal of advanced nursing, 75(9), 1922–1932. https://doi.org/10.1111/jan.13980

Relevant Categories
Cardiovascular Diseases
Mental Health
Metabolic Disorders
Terminal Illness
Learn more

Related Publications

Grant - Wang, W. W. (PI) 2020-2023. Health Services Research Grant. An Integrative Cardiac Rehabilitation Employing Smartphone Technology (i-CREST) for patients with post-myocardial infarction: A randomized controlled trial, SG$614,980, Ministry of Health.

Chan, G.F.K., Jiang, Y., Choo, W.T., Ramachandran, H.J., Lin, Y., Wang, W. (2022). Effect of exergaming on functional outcomes in people with chronic stroke: A systematic review and meta-analysis. Journal of Advanced Nursing, 78(4), 929-946. doi: 10.1111/jan.15125

Choo, W. T., Jiang, Y., Chan, K. G., Ramachandran, H. J., Teo, J. Y., Seah, C. W. & Wang, W.(2022). Effectiveness of caregiver-mediated exercise interventions on activities of daily living, anxiety and depression post-stroke rehabilitation: A systematic review and meta-analysis. Journal of Advanced Nursing, 78, 1870– 1882. https://doi.org/10.1111/jan.15239