Neural balance in the brain is associated with brain maturity and better cognitive ability
Published: 13 Jun 2024
Neural Excitation-Inhibition ratio decreases with development. Youths with higher cognitive ability exhibit a lower excitation-inhibition ratio. The strongest effects are seen in the association cortex (the blue portion in the above diagram), which is the portion of the brain involved in higher cognitive functions, such as language and mathematics. Photo Credits: Yong Loo Lin School of Medicine
In a world where external and internal stimuli can throw our entire body system off balance, how does our brain prevent itself from becoming overly stimulated?
The answer lies in our brain’s ability to maintain the balance of neural excitation (E) and inhibition (I), known as the E/I ratio. By regulating the E/I ratio, the brain prevents over-stimulation and under-stimulation.
The E/I ratio of children decreases with healthy development. Children with a lower E/I ratio were observed to have better performance than their peers in cognitive tests such as memory and intelligence, according to studies by researchers from the Centre for Sleep and Cognition at the Yong Loo Lin School of Medicine (NUS Medicine).
The study team, led by fourth-year PhD student Zhang Shaoshi, Associate Professor Thomas Yeo from the Centre for Sleep and Cognition at NUS Medicine, Assistant Professor Bart Larsen from the University of Minnesota and Associate Professor Theodore Satterthwaite from the University of Pennsylvania, looked at how E/I ratio changes in youths, by studying the MRI brain scans of 885 children, adolescents and young adults from the United States of America and 154 children from Singapore. E/I ratio is an aspect that is continually changing and developing throughout childhood and adolescence.
Described as the Yin and Yang of the brain, researchers have found that too much excitation or excessive inhibition can be harmful, leading to a higher risk of developing brain disorders, such as autism, Alzheimer’s disease and schizophrenia. Too much inhibition indicates an absence of brain activity, effectively putting the person in a vegetative state.
Without the need for invasive techniques, the team developed a technique, combining artificial intelligence and biophysical modeling to infer E/I ratios from non-invasive, non-radioactive MRI scans. The team demonstrated the validity of their estimated E/I ratios through an experiment, during which participants ingested anti-anxiety medication (Xanax) or a placebo.
The team’s hypothesis is that once Xanax was ingested, inhibition will increase, so the overall E/I ratio decreases. To test this hypothesis, the research team scanned healthy individuals on two separate occasions. A participant is given Xanax before one MRI session and placebo in another MRI session. For some participants, Xanax might be administered in the first session, while for others Xanax might be administered in the second session. The team found that estimated E/I ratio markers were indeed lower after participants had ingested Xanax, compared with the placebo, and thus validating their technique.
The study team then proceeded to use MRI brain scans to study brain development in a large sample of more than 1000 children, adolescents and young adults from Singapore and the United States of America. They discover that E/I ratios decrease with healthy development. Next, to establish the link between E/I ratios and cognitive function, the team divided participants, ranging from age 7 to 23, into high and low-performance groups based on their scores on certain cognitive tests. They found that the high performing groups had lower E/I ratios than their peers of the same age, suggesting that cognitive abilities improve as the E/I ratio matures during development.
The study is published in Proceedings of the National Academy of Sciences of the United States of America, titled ‘In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth’.
For more details, read the media release here.
