My passion and long-term career goal is to become a clinician-scientist that (1) utilises advanced techniques in neuroimaging and in vivo electrophysiology to map human cognition; and (2) apply machine learning and medical devices for neuromodulation
EDUCATION:
M.P.H., Saw Swee Hock School of Public Health, National University of Singapore, 2020
M.R.C.S., The Royal College of Surgeons of Edinburgh, 2017
M.B.B.S., Yong Loo Lin School of Medicine, National University of Singapore, 2016H-Index: 4
Total number of published peer-reviewed papers: 34
Total grant quantum: S$986,953.36
Presented research at international conferences: 23
Students supervised: 2 research assistants, 1 NUS life sciences FYP student, 2 MPH
students, 10 medical students
ROLES AND APPOINTMENTS:
01 Jul 2023 – 30 Jun 2025
Adjunct Research Fellow, Memory, Ageing, and Cognition Centre,
Department of Pharmacology, NUS Yong Loo Lin School of Medicine
https://medicine.nus.edu.sg/macc/
01 Jun 2023 – Ongoing
Junior Clinician Scientist Sub-Committee Member, NUHS Clinician Scientist Academy
https://medicine.nus.edu.sg/csa/
01 Jul 2021 – 30 Jun 2026
Neurosurgery Clinician Scientist Residency, Singapore
https://www.singhealthacademy.edu.sg/residency/programmes/clinicianscientist-residency-track
01 Jul 2019 – 30 Jun 2025
Singapore Integrated Programme for Neurosurgery
https://www.singhealthacademy.edu.sg/residency/programmes/Pages/Re
sidency-Programmes/neurosurgery/about-us.aspx
17-20 Jan 2023
Nominated for and Attended 11th Global Young Scientists Summit (GYSS), Singapore
https://www.nrf.gov.sg/gyss/home
15 Apr 2021 – 31 Mar 2023
Member of the Singapore National Advance Care Planning (ACP) Research and Development Workgroup
https://www.aic.sg/care-services/advance-care-planning
01 Nov 2019 – 31 May 2022
Secretary for the Society of Behavioural Health, Singapore
https://www.sgbehaviouralhealth.com/
01 Dec 2019 – 04 Dec 2022
Team Leader and Mentor, SG Healthcare AI Datathon
01 Jan 2012 – Ongoing
Project Founder and Project Mentor, Project Happy Apples (PHA)
https://www.projecthappyapples.com/
01 Jan 2018 – 30 Jun 2019
Staff Officer (Healthcare), Military Medicine Institute
01 Oct 2017 – 30 Sep 2019
Adjunct Research Fellow, Singapore Institute of Neurotechnology
(SiNAPSE), National University of Singapore
HONORS AND AWARDS:
31 Mar 2023 National Outstanding Clinician Scientist Resident Award 2022, Ministry of Health, Singapore
9 Sep 2022 NUHS Residency Research Award 2022 (Silver)
11 Aug 2022 Outstanding Resident Award, Residency in SingHealth Excels (RiSE) Awards 2022
01 Aug 2020 Valedictorian and Winner of Tye Cho Yook Gold Medal Award, Saw Swee Hock School of Public Health, National University of Singapore
RESEARCH FOCUS:
THE PATHOPHYSIOLOGY OF POST-STROKE COGNITIVE IMPAIRMENT AND DEMENTIA IN SPONTANEOUS INTRACEREBRAL HEMORRHAGE;MAPPING HUMAN COGNITION AND DEVELOPMENT OF NEUROMODULATION INTERVENTIONS FOR COGNITIVE REHABILITATION AND RESTORATION
RELEVANT PUBLICATIONS:
1. Lim MJR, Tan J, Gyanwali B, Tanaka T, Reilhac A, Vrooman HA, Chen C, Hilal S. The Associations Between Intracranial Stenosis, Brain Amyloid-beta, and Cognition in a Memory Clinic Sample. Alzheimer Dis Assoc Disord. 2022 Oct-Dec 01;36(4):327-334. doi: 10.1097/WAD.0000000000000533. Epub 2022 Oct 26. PMID: 36445223.
2. Lim MJR, Zheng Y, Soh RY, Foo QXJ, Djohan AH, Nga Diong Weng V, Ho JS, Yeo TT, Sim HW, Yeo TC, Tan HC, Chan MY, Loh JP, Sia CH. Symptomatic intracerebral hemorrhage after non-emergency percutaneous coronary intervention: Incidence, risk factors, and association with cardiovascular outcomes. Front Cardiovasc Med. 2022 Sep 16;9:936498. doi: 10.3389/fcvm.2022.936498. PMID: 36186990; PMCID: PMC9524143.
3. Lim MJR, Tan J, Tan BY, Yeo TT, Sharma VK. Air Pollution and Intracranial Hemorrhage. Ann Indian Acad Neurol. 2022 Sep;25(Suppl 1):S22-S25. doi: 10.4103/aian.aian_1131_21. Epub 2022 Mar 25. PMID: 36213099; PMCID:PMC9540825.
4. Ho AFW*, Lim MJR* (co-first author), Zheng H, Leow AS, Tan BY, Pek PP, Raju Y, Seow WJ, Yeo TT, Sharma VK, Aik J, Ong MEH. Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry. Int J Hyg Environ Health. 2022 Mar;240:113908. doi: 10.1016/j.ijheh.2021.113908. Epub 2021 Dec 30. PMID: 34974273.
5. Lim MJR, Tan CS, Gyanwali B, Chen C, Hilal S. The effect of intracranial stenosis on cognitive decline in a memory clinic cohort. Eur J Neurol. 2021 Jun;28(6):1829-1839. doi: 10.1111/ene.14788. Epub 2021 Mar 18. PMID: 33630355.
GRANTS AWARDED:
Apr 2023 – Mar 2025
NUHS Clinician Scientist Program (NCSP) 2.0, Principal Investigator, Total Amount: S$240,000 to project and $160,000 to department. Title: PREdiction and PAThophysiology of Cognitive Health in Spontaneous IntraCerebral Hemorrhage (The PREPATCH-SICH Study). NCSP2.0/2023/NUHS/ML.
May 2021 – Nov 2023
NUHS Family Medicine/Primary Care/Health Services Research (FM/PC/HSR) Seed Grant 2020, Principal Investigator, Total Amount: S$50,000. Title: Quality of Life, Cognition and Employment in Spontaneous Intracerebral Hemorrhage. NUHSRO/2021/011/RO5+6/FMPCHSRG-Sep20/03.
CONFERENCE PRESENTATIONS:
Sep 2023
EANS 2023 Barcelona (Neurosurgery & Technology at the Service of Humanity): Association of Cerebral Small Vessel Disease and Cognitive Impairment in Six Cognitive Domains after Spontaneous Intracerebral Hemorrhage
Sep 2023
Congress of Neurological Surgeons 2023: Associations between inflammatory markers and outcomes in spontaneous intracerebral hemorrhage (SICH)
Jun 2023
10th International Brain Computer Interface (BCI) Society Meeting 2023: A systematic review of invasive brain-computer interfaces in humans: current state-of-the-art and features associated with accuracy of an invasive BCI task
Jul 2022
Alzheimer’s Association International Conference 2022: Associations between hippocampal subfield volume and cognitive performance
Jul 2021
Alzheimer’s Association International Conference 2021. Intracranial stenosis interacts with Amyloid Positron Emission Tomography (PET) Standard Uptake Value Ratio (SUVR) to predict cognitive decline in a memory clinic cohort.
Jul 2020
Alzheimer’s Association International Conference 2020. Intracranial Stenosis Predicts Cognitive Decline in a Memory Clinic Cohort.
May 2017
6th World Intracranial Hemorrhage Conference 2017. Validation and Evaluation of Clinical Prognostic Scores in Spontaneous Intracerebral Hemorrhage: A Retrospective Study.
Jul 2015
ASEAN 2015 Neuroscience Conference. Electrical Microstimulation of the Prefrontal Cortex During a Fixation Task.
RESEARCH FOCUS: APPLICATION OF ARTIFICIAL INTELLIGENCE SOLUTIONS FOR PROGNOSTICATION AND PERSONALISED MEDICINE IN NEUROSURGERY
RELEVANT PUBLICATIONS:
1. Toh EMS, Ng KJ, Motani M, Lim MJR. Letter: Deep Neural Networks Can Accurately Detect Blood Loss and Hemorrhage Control Task Success from Video. Neurosurgery. 2023 Jul 18. doi: 10.1227/neu.0000000000002590. Epub ahead of print. PMID: 37462368.
2. Toh EMS, Yan B, Lim IC, Yap DM, Wee WJ, Ng KJ, Nga VDW, Motani M, Lim MJR. The role of intracranial pressure variability as a predictor of intracranial hypertension and mortality in critically ill patients. J Neurosurg. 2023 May 19:1-8. doi:10.3171/2023.4.JNS23123. Epub ahead of print. PMID: 37209075.
3. Lim MJR, Quek RHC, Ng KJ, Loh NW, Lwin S, Teo K, Nga VDW, Yeo TT, Motani M.Machine Learning Models Prognosticate Functional Outcomes Better than Clinical Scores in Spontaneous Intracerebral Haemorrhage. J Stroke Cerebrovasc Dis. 2022 Feb;31(2):106234. doi: 10.1016/j.jstrokecerebrovasdis.2021.106234. Epub 2021 Dec 10. PMID: 34896819.
4. Lim MJR. Letter: Machine Learning and Artificial Intelligence in Neurosurgery: Status, Prospects, and Challenges. Neurosurgery. 2021 Nov 18;89(6):E333-E334. doi:10.1093/neuros/nyab337. PMID: 34498686.
5. Lim MJR, Neo AYY, Singh GD, Liew YST, Rajendram MF, Tan MWX, Ragupathi T, Lwin S, Chou N, Sharma VK, Yeo TT. The Evaluation of Prognostic Scores in Spontaneous Intracerebral Hemorrhage in an Asian Population: A Retrospective Study. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105360. doi: 10.1016/j.jstrokecerebrovasdis.2020.105360. Epub 2020 Oct 15. PMID: 33069085.
RESEARCH AWARDS:
4 Dec 2022
Second Runner-Up, SG Healthcare AI Datathon & EXPO 2022. Project Title: An Unsupervised Approach to Understanding Spontaneous Intracerebral Hemorrhage (SICH) Phenotypes
5 Dec 2021
Championship, SG Healthcare AI Datathon 2021. Project Title: Hourly IntraCranial pressure Changes Using a Predictive Model (Project HICCUP)
GRANTS AWARDED:
Oct 2021 – Oct 2023
Engineering in Medicine Pitch-for-fund Competition 2021, Principal Investigator, Total Amount: S$50,000. Title: AI-SICH: Artificial Intelligence Solutions for Prognostication and Development of a Clinician-Decision Support System in Spontaneous Intracerebral Hemorrhage. NUHSRO/2021/049/RO5+6/EIM-3rd/01.
Jun 2021 – Jun 2023
NUH Junior Pitch for Funds Grant Award 2021, Principal Investigator, Total Amount: S$3,500. Title: Predicting Risk of Expansion of Hematoma and Outcomes of Spontaneous Intracerebral Hemorrhage (SICH) from CT Brain and Angiogram DICOM Images Using Artificial Intelligence.
CONFERENCE PRESENTATIONS:
Sep 2023
EANS 2023 Barcelona (Neurosurgery & Technology at the Service of Humanity): The role of intracranial pressure variability as a predictor for intracranial hypertension and mortality in critically ill patients
Oct 2022
Congress of Neurological Surgeons 2022: Prognostication of Outcomes and Surgical Intervention in Spontaneous Intraparenchymal Hemorrhage: A Propensity Score-matched Analysis with Support Vector Machine
Dec 2021
SG Healthcare AI Datathon and Expo 2021: Machine Learning Models Prognosticate Functional Outcomes better than Clinical Scores in Spontaneous Intracerebral Hemorrhage
OTHER RESEARCH: IMPROVING FUNCTIONAL OUTCOMES, QUALITY OF LIFE, AND END-OF-LIFE CARE IN PATIENTS SUFFERING FROM NEUROSURGICAL DISEASES
ISCHEMIC AND HEMORRHAGIC STROKE:
1. Tan SM, Ho JS, Sia CH, Leow AS, Seet RC, Teoh HL, Yuen LZ, Tham CH, Chua CY, Yap ES, Chan BP, Lim MJ, Sharma VK, Yeo LL, Tu TM, Tan BY. Etiologies, mechanisms, and risk factors of ischemic stroke in a young Asian adult cohort. J Stroke Cerebrovasc Dis. 2023 May 10;32(8):107134. doi:10.1016/j.jstrokecerebrovasdis.2023.107134. Epub ahead of print. PMID: 37172470.
2. Lim NA, Lin HY, Tan CH, Ho AFW, Yeo TT, Nga VDW, Tan BYQ, Lim MJR* (co-last author), Yeo LLL*. Functional and Mortality Outcomes with Medical and Surgical Therapy in Malignant Posterior Circulation Infarcts: A Systematic Review. J Clin Med. 2023 Apr 28;12(9):3185. doi: 10.3390/jcm12093185. PMID: 37176624; PMCID: PMC10179120.
3. Lim MJR, Yeo J, Fong KY, Eng SW, Fu S, Tan BY, Yeo LLL, Nga VDW, Yeo TT.
Characteristics of subarachnoid hemorrhage associated with COVID-19 infection: A systematic review and descriptive analysis. J Stroke Cerebrovasc Dis. 2023 Feb;32(2):106904. doi: 10.1016/j.jstrokecerebrovasdis.2022.106904. Epub 2022 Nov 22. PMID: 36442281; PMCID: PMC9678815.
4. Goh S, Tan NHW, Tan CH, Leow AST, Sia CH, Ho AFW, Lim MJR, Yeo LLL, Tan BYQ. Evaluating the safety and efficacy of intravenous thrombolysis for acute ischemic stroke patients with a history of intracerebral hemorrhage: a systematic review and meta-analysis. J Thromb Thrombolysis. 2022 Feb;53(2):485-494. doi:10.1007/s11239-021-02531-2. Epub 2021 Jul 24. PMID: 34302590.
5. Lim MJR, Wong BTY, Koh PPW, Raszewski R, Asano M (2019) A Brief Review of Post-stroke Employment in Singapore. Int J Neurorehabilitation 6: 354.
6. Thien A, See AA, Ang SY, Primalani NK, Lim MJR, Ng YP, King NK. Prevalence of Asymptomatic Unruptured Intracranial Aneurysms in a Southeast Asian Population. World Neurosurg. 2017 Jan;97:326-332. doi: 10.1016/j.wneu.2016.09.118. Epub 2016 Oct 12. PMID: 27744074.
CENTRAL NERVOUS SYSTEM TUMORS:
1. Lim MJR, Wee GMR, Aw MYN, Liu JS, Ho WLC, Teo K, Lwin S, Yeo TT, Kimpo M, Nga DWV. Management and outcomes of paediatric craniopharyngioma: A 15-year experience in Singapore. World Neurosurg. 2023 Jul 3:S1878-8750(23)00838-0. doi:10.1016/j.wneu.2023.06.068. Epub ahead of print. PMID: 37406798.
2. Fong KY*, Lim MJR* (co-first author), Fu S, Low CE, Chan YH, Deepak DS, Xu X, Thong M, Jain S, Teo K, Gardner PA, Snyderman CH, Nga VDW, Yeo TT. Postsurgicaloutcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis.Pituitary. 2023 Jun 30. doi: 10.1007/s11102-023-01335-2. Epub ahead of print. PMID:37389776.
3. Lim MJR, Tan EE, Wong RX, Chang KT, Fortier MV, Cheong TM, Ng LP, Low SY. Paediatric primary intracranial malignant melanoma-case report and literature review. Pediatr Neurosurg. 2023 Jun 14. doi: 10.1159/000531544. Epub ahead of print. PMID: 37315550.
4. Zheng Y, Teo K, Nga VDW, Yeo TT, Lim MJR. Risk factors for 30-day postoperative surgical site hematoma requiring evacuation after resection of brain metastases. ClinNeurol Neurosurg. 2023 Mar;226:107617. doi: 10.1016/j.clineuro.2023.107617. Epub 2023 Feb 5. PMID: 36753860.
5. Lim MJR; Zheng Y; Eng SWO; … Yeo TT. Presenting Characteristics, Histological Subtypes, and Outcomes of Adult Central Nervous System Tumours: Retrospective Review of a Surgical Cohort. Accepted for publication in Singapore Medical Journal (Aug 2022).
6. Zheng Y, Yang Y, Ng MH, Chew AYH, Goh CP, Chua CYK, Rathakrishnan R, Ang Y, Wong ALA, Vellayappan B, Teo K, Nga VDW, Yeo TT, Lim MJR. Effect of perioperative seizures on mortality and recurrence in patients with brain metastases. Front Oncol. 2022 Nov 14;12:1048304. doi: 10.3389/fonc.2022.1048304. PMID: 36452498; PMCID: PMC9701706.
7. Liu SJ, Aw NMY, Lim MJR, Tew Seow W, Low DCY, Kimpo MS, Ee Kar Tan E, Tsai Yeo T, Low SYY, Nga VDW. Paediatric brain tumours in Singapore: A 15-year epidemiological and outcome study. J Clin Neurosci. 2022 Jul;101:154-161. doi:10.1016/j.jocn.2022.05.006. Epub 2022 May 18. PMID: 35597064.
HEALTH-RELATED QUALITY OF LIFE: 1. Lim MJR. Letter: Functional Outcomes and Health-Related Quality of Life Following Glioma Surgery. Neurosurgery. 2021 Aug 16;89(3):E187-E188. doi: 10.1093/neuros/nyab214. PMID: 34131740.
END-OF-LIFE CARE:
1. Lim MJR, Foo QXJ, Chan NGC, Miny S. PROTOCOL: Community-based interventions for initiating early end-of-life conversations in nonterminally Ill adults: a systematic review. Campbell Syst Rev. 2021 May 24;17(2):e1168. doi: 10.1002/cl2.1168. PMID: 37051181; PMCID: PMC8356288.
OTHER PUBLICATIONS – PEER-REVIEWED JOURNALS:
1. Zheng Y*, Lim MJR* (co-first author), Tan BY, Chan BPL, Paliwal P, Jonathan OJY, Bharatendu C, Chan ACY, Yeo LLL, Vijayan J, Hong CS, Chee YH, Wong LYH, Chen J, Chong VYF, Dong Y, Tan CH, Sunny S, Teoh HL, Sinha AK, Sharma VK.Role of plaque inflammation in symptomatic carotid stenosis. Front Neurol. 2023 Jan 24;14:1086465. doi: 10.3389/fneur.2023.1086465. PMID: 36761341; PMCID:PMC9902904.
2. Ho AFW, Lim MJR, Earnest A, Blewer A, Graves N, Yeo JW, Pek PP, Tiah L, Ong MEH; Singapore PAROS Investigators. Long term survival and disease burden from out-of-hospital cardiac arrest in Singapore: a population-based cohort study. Lancet Reg Health West Pac. 2022 Dec 28;32:100672. doi: 10.1016/j.lanwpc.2022.100672.PMID: 36785853; PMCID: PMC9918801.
3. Toh EMS, Thenpandiyan AA, Foo ASC, Zhang JJY, Lim MJR, Goh CP, Dinesh N,Vedicherla SV, Yang M, Teo K, Yeo TT, Nga VDW. Clinical Outcomes of 3D-Printed Bioresorbable Scaffolds for Bone Tissue Engineering-A Pilot Study on 126 Patients for Burrhole Covers in Subdural Hematoma. Biomedicines. 2022 Oct 26;10(11):0. doi:10.3390/biomedicines10112702. PMID: 36359222; PMCID: PMC9687313.
4. Lim MJR, Zheng Y, Babla Singbal S, Makmur A, Yeo TT, Kumar N. Clinical and radiological characteristics of spinal epidural lipomatosis: A retrospective review of 90 consecutive patients. J Clin Orthop Trauma. 2022 Aug 13;32:101988. doi:10.1016/j.jcot.2022.101988. PMID: 36035782; PMCID: PMC9413947.
5. Lim MJR, Fong KY. Letter: Pearls for Interpreting Neurosurgical Systematic Reviews and Meta-analyses: Lessons From a Collaborative Effort. Neurosurgery. 2022 May 1;90(5):e130-e131. doi: 10.1227/neu.0000000000001896. PMID: 35196292.
6. Lim MJR*, Fong KY*, Zheng Y, Chua CYK, Miny S, Lin JB, Nga VDW, Ong HT, Rathakrishnan R, Yeo TT. Vagus nerve stimulation for treatment of drug-resistant epilepsy: a systematic review and meta-analysis. Neurosurg Rev. 2022 Jun;45(3):2361-2373. doi: 10.1007/s10143-022-01757-9. Epub 2022 Feb 26. PMID: 35217961.
7. Tan C, Lin L, Lim MJR, Ong SK, Wong ML, Lee JK. Tobacco use patterns and attitudes in Singapore young male adults serving military national service: a qualitative study. BMJ Open. 2020 Sep 28;10(9):e039367. doi: 10.1136/bmjopen- 2020-039367. PMID: 32988949; PMCID: PMC7523193.
8. Lee JK, Lin L, Lim MJR, Van Der Eijk Y, Chia KS, Tan C. National Tobacco Control Policies from the Perspectives of Singapore Young Male Adults. J Psychoactive Drugs. 2020 Jan-Mar;52(1):5-12. doi: 10.1080/02791072.2019.1706792. Epub 2019 Dec 18. PMID: 31852369.
OTHER PUBLICATIONS – OTHERS:
1. Mervyn Lim, Leonard Yeo, Benjamin Tan, Adriel Leong, Audrey Tan, Pervinder Bhogal, Yang Cunli, Anil Gopinathan. Cerebral arteriovenous malformation. BMJ Best Practice. 17 Mar 2023. https://bestpractice.bmj.com/topics/en-us/1133.
OTHER GRANTS AWARDED:
Jun 2022 – May 2027
National Innovation Challenge – Caregiving Ecosystem (CareEco), Site Principal Investigator, Total Amount for Site: S$433,962.36. Title: PEACE - Preparation for End-Of-Life with Advance Care Education. Application ID: CareEco21-0030.
Feb 2021 – Aug 2023
Singapore Cancer Society (SCS) Cancer Research Grant 2020, Principal Investigator, Total Amount: S$49,491. Title: The burden of health-related quality of life (HRQoL) in glioma and validation of a disease-specific HRQoL instrument for brain tumours in Singapore. SCS-GRA-2020-00123.
OTHER CONFERENCE PRESENTATIONS:
Sep 2023
EANS 2023 Barcelona (Neurosurgery & Technology at the Service of Humanity): Insights on Health-related Quality of Life After Glioma Surgery in a South-East Asian Population
May 2023
8th International Conference on Advance Care Planning (ACP-i 2023): Cross-sectional Survey of ACP Documentation Attitudes in a Singaporean ACP Roadshow
May 2023
8th International Conference on Advance Care Planning (ACP-i 2023): Communitybased interventions for initiating early end-of-life conversations in non-terminally Ill adults: a systematic review and meta-analysis
May 2023
8th International Conference on Advance Care Planning (ACP-i 2023): Project Happy Apples: A Medical Student-initiated Community Project for Normalising Conversations About Death in a Multi-racial South-east Asian Country
Oct 2022
Glioma Update 2022: Measuring Quality of Life in Glioma: Current Practices and Future Collaborations
Oct 2022
World Stroke Congress 2022: Comparison of Short-Term Clinical Outcomes Between Patients with Symptomatic Extracranial Carotid and/or Intracranial Atherosclerotic Disease
Sep 2022
Public Health Palliative Care International Conference 2022: Knowledge, Attitudes, and Practices of Advance Care Planning among Healthcare Workers in Neurology, Neurooncology,
and Surgery
Dec 2021
Singapore Palliative Care Conference (SPCC) Research Development Workshop
2021: Advance care planning in healthcare workers involved in the care of, and patientswith brain tumours.
Dec 2021
4th International Brain Stimulation Conference 2021. Vagus nerve stimulation for treatment of drug-resistant epilepsy: a systematic review and meta-analysis.
Oct 2021
European Associat