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Antimicrobial Resistance and Drug Discovery
Programme Code: TGS-2021004023
Mode of Delivery
On-Campus
Duration
44 hours
Date / Time
- Next Run TBA
Programme Highlights
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are responsible for deadly outbreaks and hospital-acquired infections around the globe, undermining advances in health and medicine. This has led the World Health Organization (WHO) to draft a global action plan to mitigate the threat of antimicrobial resistance (AMR), which includes more investments in drug discovery and clinical development of new antibiotics and novel interventions.
Organised by the NUS Yong Loo Lin School of Medicine, Division of Graduate Studies, this module provides a brief introduction to antimicrobial resistance, its origins, impact on healthcare and current strategies employed in the search of new antimicrobials. Participants will engage in interactive discussions on different approaches to antimicrobial drug discoveries and explore alternative therapies that are rapidly gaining interest with the recent technological advances and the growth of personalised medicine.
Course Objectives:
- This module addresses both antimicrobial resistance and drug discovery, which are essential in preparing young scientists to address these issues
- Lectures on emerging medical technologies are addressed, including principles on mechanisms of action and resistance of antimicrobials as well as the process of drug discovery in pharmaceutical, biotechnology and academic fields
- Topics in drug discovery include conventional screening of small molecules as well as antibody and immunotherapy, CAR-T cell therapy, phage therapy and microbiome based-therapy
Benefits of Attending
This course can be broadly divided onto three main topics: i) understanding the origin and source of antimicrobial resistance, ii) learning the process of drug discovery in pharma, start-ups and the academic environment, and iii) exploring novel and disruptive new strategies in antimicrobial discovery.
At the completion of this course the participant should have a basic understanding of
- The origins and sources of antimicrobial resistance
- Basic knowledge on mechanisms of drug resistance
- Some of the challenges posed by antimicrobial resistance
- Bases of drug discovery in Big Pharma and how it contrasts to Start-ups and Academia
- Concurrent and novel strategies in drug discovery
- Bases for critical evaluations of different strategies employed in drug discovery
Who Should Attend
- Researchers and clinicians in public/private hospitals working on antimicrobial resistance and chemotherapy for infections
- Lab medicine / infectious diseases division personnel in hospitals
- Pharmaceutical company personnel interested in drug discovery
Trainer Profile
Course Agenda
Please download the course timetable for more details.
- Classes will commence from 15 Aug 2022 to 23 Nov 2022.
- Lectures will be conducted every Monday and Wednesday, 6pm – 8pm.
.
Topics
Description
- Course Introduction: Antimicrobial Resistance (AMR) Overview
- Antimicrobial mechanisms of action and resistance
- Phage and combination phage-antibiotic therapy
- Nosocomial Infections
- Drug resistance and sexually transmitted infections
- Principles in Drug-Discovery I
- Early stages in drug discovery for anti-infectives
- Computer aided drug discovery
- Tuberculosis drug discovery From the benchtop to the clinic
- COVID-19 biology, prevention and treatment
- COVID-19 drug discovery
- Immunotherapy
- Animal models in drug discovery
- Molecular Imaging in Infectious Disease
- Phage and combination phage-antibiotic therapy
- Host-target and drug discovery
- Student seminars and discussions
Pre-Requisites and Assessment
- Participants are required to have at least a Bachelor’s or Master’s Degree in related fields such as Biology, Bioengineering, Life Science, Health, Medicine and Biotechnology
Assessment consists of:
- 50% Tutorials/Presentation
- 10% Class Participation
- 40% Report
Awards and Certification
Learners must record at least 75% attendance and pass all assessment components to successfully complete the course and receive a Certificate of Completion.
Course Fee
International Participants
Singapore Citizens1 39 years old or younger
Singapore Citizens1 40 years old or older eligible for MCES2
Singapore PR
Enhanced Training Support For SMEs3
Full Programme Fee
$5400
$5400
$5400
$5400
$5400
Less: SSG Grant Amount4
–
$3780
$3780
$3780
$3780
Nett Course Fee
$5400
$1620
$1620
$1620
$1620
7% GST on Nett Course Fee
$378
$113.40
$113.40
$113.40
$113.40
Total Nett Course Fee Payable including GST
$5778
$1733.40
$1733.40
$1733.40
$1733.40
Less Additional Funding if Eligible Under Various Schemes
–
–
$1080
–
$1080
Total Nett Cost Fee Payable, Including GST, after additonal funding from the various funding schemes
$5778
$1733.40
$653.40
$1733.40
$653.40
1) All self-sponsored Singaporean aged 25 and above can use their SkillsFuture Credit to pay for the course fee.
2) Mid-Career Enhanced Subsidy (MCES): Singaporeans aged 40 and above may enjoy subsidies up to 90% of the course fee.
3) Enhanced Training Support for SMEs (ETSS): SME-sponsored employees (Singapore Citizens and PRs) may enjoy subsidies up to 90% of the course fee.
4) Learners must record at least 75% attendance and pass all assessment components to successfully complete the course and receive a Certificate of Completion.
Application Deadline
TBA.
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