Appointment(s)
Associate Professor, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Assistant Dean (Administration), Yong Loo Lin School of Medicine, National University of Singapore
Principal Investigator, NUS Immunology Program, Life Sciences Institute
Degree(s)
Ph.D in Pharmacology, Queen Mary Westfield College, University of London, UK (2000)
BSc in Pharmacology, Kings College London, University of London, UK (1996)
Biography
A/Prof Lina is an immunologist with more than 20 years of experience in inflammatory diseases and models such as asthma, infection, and cancer. A major focus of her research is to understand the regulation of inflammation and immune responses, particularly the dysregulation caused by the protein Annexin-1, with respect to disease etiology, particularly tumourigenesis, and the tumour and innate immune response.
Her recent interests focus on the role of chronic stress (environmental and psychological) and stress hormones in breast cancer development and progression. She is now involved in three external projects with colleagues from nursing and psychological medicine, studying the impact of stress and interventions such as mindfulness, forest walking, and choral singing on disease and quality of life.
Influence of Oxytocin on Parenting Behaviors and Parent-child Bonding: A Systematic Review. Developmental Psychobiology 2023, 65(2): e22359
Shorey S, Asurlekar AR, Chua JS, Lim LHK.
Annexin-A1 - A Blessing or a Curse in Cancer. Trends Mol Med. 2019 Apr;25(4):315-327.
Foo SL, Yap G, Cui J, Lim LHK.
RNA-Sequencing-Based Transcriptomic Analysis Reveals a Role for Annexin-A1 in Classical and Influenza A Virus-Induced Autophagy. Cells. 2020;9(6):1399.
Cui J, Morgan D, Cheng DH, et al.
Annexin-A1 promotes RIG-I-dependent signaling and apoptosis via regulation of the IRF3-IFNAR-STAT1-IFIT1 pathway in A549 lung epithelial cells. Cell Death Dis. 2020;11(6):463.
Yap GLR, Sachaphibulkij K, Foo SL, Cui J, Fairhurst AM, Lim LHK.
Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling. Breast Cancer Res. 2022 Apr 5;24(1):25.
Foo SL, Sachaphibulkij K, Lee CLY, Yap GLR, Cui J, Arumugam T, Lim LHK.
Annexin-A1 deficiency attenuates stress-induced tumor growth via fatty acid metabolism in mice: an Integrated multiple omics analysis on the stress- microbiome-metabolite-epigenetic-oncology (SMMEO) axis. Theranostics 2022; 12(8):3794-3817.
Cui J, Sachaphibulkij K, Teo WS, Lim HM, Zou L, Ong CN, Alberts R, Chen J, Lim LHK.
Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST. Nat Commun. 2023 Mar 1;14(1):1155. doi: 10.1038/s41467-023-36796-3. PMID: 36859400; PMCID: PMC9977836.
Long Y, Ang KS, Li M, Chong KLK, Sethi R, Zhong C, Xu H, Ong Z, Sachaphibulkij K, Chen A, Zeng L, Fu H, Wu M, Lim LHK, Liu L, Chen J.
Macrophage IL-1β contributes to tumorigenesis through paracrine AIM2 inflammasome activation in the tumor microenvironment. Front Immunol. 2023 Jun 28;14:1211730. doi: 10.3389/fimmu.2023.1211730. PMID: 37449203; PMCID: PMC10338081.
Chew ZH, Cui J, Sachaphibulkij K, Tan I, Kar S, Koh KK, Singh K, Lim HM, Lee SC, Kumar AP, Gasser S, Lim LHK.
