Appointment(s)
Associate Professor, Department of Physiology,
Assistant Dean, Safety and Research Facilities Management,
Chair, NUSMedicine Safety Committee
Head, Research Safety, NUHS
Degree(s)
Doctor of Philosophy (Radiation Biology), Mangalore University, Mangalore, India (19 Jan 1987 – 21 Nov 1991)
Master of Public Health, Medicine, National University of Singapore, Singapore (13 Aug 2007 – 31 May 2010)
Master of Science, Sciences, University of Mysore, India (6 Aug 1984 – 31 Aug 1986)
Bachelor of Science, Sciences, Mangalore University, Mangalore, India (1 Jun 1981 – 30 Apr 1984)
Biography
Manoor Prakash HANDE is an Associate Professor at the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS). He has authored over 180 peer-reviewed research articles in prestigious international journals, including Nature Genetics, Cell, Science, Genes and Development, and PNAS, achieving a Scopus H-index of 56 and approximately 14,500 citations.
Dr Hande’s research focuses on telomeres and telomerase in ageing and cancer, experimental cancer therapeutics, and biomarkers of radiation exposure. He is actively involved in teaching cancer biology and ageing to life sciences students. At Tembusu College, NUS, he conducted interdisciplinary seminars, such as “Biomedicine and Singapore Society” and “Radiation and Society.”
He holds adjunct professor roles at Vellore Institute of Technology in India and Mangalore University in India. During his sabbatical from NUS (2015–2016), he served as a consultant for the Division of Human Health at the International Atomic Energy Agency (IAEA) in Vienna, Austria.
From 2017 to 2021, Dr. Hande was an expert member of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). Since July 2021, he has been a member of Committee 1 of the International Commission on Radiological Protection (ICRP). He co-chairs the ICRP Task Group 121 on the effects of ionizing radiation exposure in offspring and future generations and is a member of Task Group 118 on Relative Biological Effectiveness (RBE), Quality Factor (Q), and Radiation Weighting Factor (wR).
Dr. Hande has been on the editorial board of Mutation Research – Genetic Toxicology and Environmental Mutagenesis since 2017 and became its Regional Editor in July 2022. He has also served as an Associate Editor for the International Journal of Radiation Biology since November 2021. In July 2021, he was appointed Assistant Dean of Safety and Research Facilities Management at the Yong Loo Lin School of Medicine, NUS
Effects of dietary interventions on telomere dynamics. Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 876 – 877: 503472 (doi: 10.1016/j.mrgentox.2022.503472)
Ng GY, Hande V, Ong MH, Wong BW, Loh ZW, Ho WD, Handison LB, Tan IMP, Fann DY, Arumugam TV, Hande MP
Use of peptide nucleic acid probe to determine telomere dynamics in improving chromosome analysis in genetic toxicology studies. Mutation Research – Genetic Toxicology and Environmental Mutagenesis Vol. 897: 503773
Ng GYQ, Hande MP
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair
Shokrollahi M, Stanic M, Hundal A, Chan JNY, Urman D, Hakem A, Garcia RE, Hao J, Maass P, Dickson BC, Hande MP, Pujana MA, Hakem R, Mekhail K
Educational dialogue on public perception of nuclear radiation. International Journal of Radiation Biology 98(2): 158 – 172
Hande V, Prathaban K, Hande MP
Massively parallel single-molecule telomere length measurements with digital real-time PCR. Science Advances 6(34): eabb7944 (doi: 10.1126/sciadv.abb7944).
Luo Y, Viswanathan R, Hande MP , Loh AHP, Cheow LF
Chromosomal instability – mechanisms and consequences. Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 793: 176- 184. (doi: 10.1016/j.mrgentox.2015.08.008)
Venkatesan S, Natarajan AT, Hande MP
Targeting DNA-PKcs and telomerase in brain tumour cells. Molecular Cancer 13(1): 232 doi: 10.1186/1476-4598-13-232.
Gurung R, Lim HK, Venkatesan S, Lee PSW, Hande MP
Telomere dysfunction-induced cellular senescence in human cancer precursor lesions. EMBO J 31(13): 2839 - 2851.
Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d’Adda di Fagagna F, Herbig U
Anti-proliferative activity of silver nanoparticles. BMC Cell Biology 10: 65.
AshaRani PV, Hande MP, Valiyaveettil S
Cytotoxic and genotoxic effects of silver nanoparticles in human cells. ACS Nano 3 (2): 279-290.
AshaRani PV, Low GKM, Hande MP, Valiyaveettil S
Involvement of mammalian Mus81 in genome integrity and tumour suppression. Science 304 (5678): 1822-1826.
McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-Sweatman, Khokha R, Kanaar R, Jasin M, Hande MP, Hakem R.
Collaboration of Brca1 and Chk2 in tumorigenesis. Genes and Development 18: 1144-1153.
McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R
Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. American Journal of Human Genetics 72 (5): 1162-1170.
Hande MP, Azizova TV, Geard CR, Burak LE, Mitchell CR, Khokhryakov VF, Vasilenko FK, Brenner DJ
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nature Genetics 23: 76-80
d’Adda di Fagagna, F*, Hande MP*, Tong WM, Lansdorp PM, Wang ZQ, Jackson SP
Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. Journal of Cell Biology 144: 589-601.
Hande MP, Samper E, Lansdorp P, Blasco MA
Blasco MA, Lee H-W, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34
Effect of in utero exposure to diagnostic ultrasound on the postnatal survival and growth of mouse. Teratology 48(5): 405- 411. (doi: 10.1002/tera.1420480504).
Hande MP, Devi PU
Teratogenic effect of hyperthermia during early organogenesis period in mice. Teratogenesis Carcinogenesis Mutagenesis 13(3): 145 – 150. (doi: 10.1002/tcm.1770130305).
Hande MP, Veena K
