Prof-Tan-Soo-Yong

Assoc Prof Tan Soo Yong

ORCID: 0000-0002-6348-2823

Appointment(s)

Associate Professor and Head, Department of Pathology, Yong Loo Lin School of Medicine, National University Singapore
Head and Senior Consultant, Department of Pathology, National University Hospital 
Group Chief of Pathology, National University Health System 
Expert Advisor, Health Regulation Group, Ministry of Health
Research Director, Advanced Molecular Pathology Laboratory and BioPharma Innovation Solutions, IMCB



Degree(s)

MBBS, DipRCPath, FRCPath, DMJ, DPhil (Oxon)



Biography

Dr Tan Soo Yong is Group Chief of Pathology, National University Health Systems and Associate Professor and Head of the Department of Pathology, National University of Singapore. Apart from his concurrent appointments as Research Director, Advanced Molecular Pathology Laboratory in IMCB, A*STAR, Visiting Consultant to National Skin Centre and Advisor to the Ministry of Health Singapore, he was Chairman, National Pathology Clinical Governance and Performance Workgroup, the founding Chief Examiner in Pathology and Chair of the Residency Advisory Committee for Pathology. For his services, he was awarded the Distinguished Senior Physician Award and 10-years Long Service Award by MOH. He is also recipient of the The Long Service Medal Pingat Bakti Setia (2022), the COVID Resilience Medal (2023) and the Public Administration Medal (Bronze) Pingat Pentadbiran Awam (Gangsa) in 2023.

He obtained his medical qualifications from the National University of Singapore and qualified in both forensic and histopathology. He is a Fellow of the Royal College of Pathologists (UK) and a Diplomate of the Society of Apothecaries of London. Dr Tan obtained his PhD from Oxford. He is a member of the International Lymphoma Study Group (ILSG) and a contributing author to the WHO Classifications of haematolymphoid neoplasms, tumours of the skin and tumours of the digestive tract. Dr Tan sits on the Editorial Board of the Journal of Hematopathology and for many years, was Chair of the Biobanking Subcommittee, Asian Network of Research Resource Centers.

An educator at heart, he was the founding Course Director at Duke-NUS Graduate Medical School and had Visiting Professorships at University Malaya (Malaysia), Guangdong Academy of Medical Sciences (China) and Universitas Padjadjaran (Indonesia). For many years, Dr Tan was also the International Advisor (West Pacific) of the Royal College of Pathologists and had initiated a postgraduate pathology training program in Myanmar. He successfully introduced next-generation sequencing (NGS) as a new service in NUH and also led consultancy initiatives in Indonesia and Myanmar. His current research interests include the cellular origins of intestinal T-cell lymphoma and the use of novel technologies such as miRNA profiling and AI in lymphoma diagnosis.


Selected Publications

A comprehensive AI model development framework for consistent Gleason grading

Huo X, Ong KH, Lau KW, Gole L, Young DM, Tan CL, Zhu X, Zhang C, Zhang Y, Li L, Han H, Lu H, Zhang J, Hou J, Zhao H, Gan H, Yin L, Wang X, Chen X, Lv H, Cao H, Yu X, Shi Y, Huang Z, Marini G, Xu J, Liu B, Chen B, Wang Q, Gui K, Shi W, Sun Y, Chen W, Cao D, Sanders SJ, Lee HK, Hue SS-S, Yu W, Tan SY

Tissue-Specific microRNA Expression Profiling to Derive Novel Biomarkers for the Diagnosis and Subtyping of Small B-Cell Lymphomas

Hue SS-S, Jin Y, Cheng H, Bin Masroni MS, Tang LWT, Ho YH, Ong DB-L, Leong SM, Tan SY

Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders

Hue SS, Ng SB, Wang S, Tan SY

Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma

Huang D, Lim JQ, Cheah DMZ, Kahliab KHBM, Laurensia Y, Pang JWL, Wong EKY, Chia BKH, Goh J, Zhang X, Chan JY, Chow EK-H, Tan SY, Lim ST, Ong CK

JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma

Nairismägi ML, Tan J, Lim JQ, Nagarajan S, Ng CC, Rajasegaran V, Huang D, Lim WK, Laurensia Y, Wijaya GC, Li ZM, Cutcutache I, Pang WL, Thangaraju S, Ha J, Khoo LP, Chin ST, Dey S, Poore G, Tan LH, Koh HK, Sabai K, Rao HL, Chuah KL, Ho YH, Ng SB, Chuang SS, Zhang F, Liu YH, Pongpruttipan T, Ko YH, Cheah PL, Karim N, Chng WJ, Tang T, Tao M, Tay K, Farid M, Quek R, Rozen SG, Tan P, Teh BT, Lim ST, Tan SY, Ong CK

Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype

Tan SY, Chuang SS, Tang T, Tan L, Ko YH, Chuah KL, Ng SB, Chng WJ, Gatter K, Loong F, Liu YH, Hosking P, Cheah PL, Teh BT, Tay K, Koh M, Lim ST

Janus Kinase 3-Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Koo GC, Tan SY, Tang T, Poon SL, Allen GE, Tan L, Chong SC, Ong WS, Tay K, Tao M, Quek R, Loong S, Yeoh KW, Yap SP, Lee KA, Lim LC, Tan D, Goh C,Cutcutache I, Yu W, Young Ng CC, Rajasegaran V, Heng HL, Gan A, Ong CK, Rozen S, Tan P, Teh BT, Lim ST

Nuclear expression of MATK is a novel marker of type II enteropathy-associated T-cell lymphoma

Tan SY, Ooi AS, Ang MK, Koh M, Wong JC, Dykema K, Ngeow J, Loong S, Gatter K, Tan L, Lim LC, Furge K, Tao M, Lim ST, Loong F, Cheah PL, Teh BT

Intestinal T-cell lymphoma. In: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (revised 4th edition). Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R, eds. Lyon, France: IARC; 2017, p372-380.

Jaffe ES, Chott A, Ott G, Chan JKC, Bhagat G, Tan SY, Stein H, Isaacson PG

Monomorphic epitheliotropic intestinal T-cell lymphoma. In: WHO Classification of Tumours: Digestive System Tumours (5th edition). WHO Classification of Tumours Editorial Board, eds. Lyon, France: IARC; 2019, p390-392.

Tan SY, de Level, L.

Intestinal T-cell lymphoma, NOS. In: WHO Classification of Tumours: Digestive System Tumours (5th edition). WHO Classification of Tumours Editorial Board, eds. Lyon, France: IARC; 2019, p393-396.

Bhagat G, Tan SY.