Reshma Taneja

Reshma Taneja

PhD

Professor, Head of Department

Affiliations

  • Head of Department, Department of Physiology, National University of Singapore
  • Professor, Department of Physiology, National University of Singapore
  • Healthy Longevity Translational Research Programme (primary)
  • NUS Centre for Cancer Research Translational Research Programme Translational Research Programme (secondary)
  • Cardiovascular-Metabolic Disease Translational Research Programme (secondary)

Research Areas of Interest:

  • Epigenetic regulation of skeletal muscle differentiation and regeneration
  • Chromatin signalling networks in myopathies

Selected Publications

  1. Das D, Leung JY, Balamurugan S, Tergaonkar V, Loh A, and Taneja R. (2024). BRD4 isoforms have distinct roles in tumor progression and metastasis in rhabdomyosarcoma. EMBO Reports in press
  2. Karthik N, Lee J, Soon J, Chiu HY, Loh A, Ong D, Tam WL, Taneja R. (2023). Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma. J Pathology 259(3):342-356
  3. Chiu HY, Loh A and Taneja R. (2022). MCU dependent mitochondrial calcium uptake regulates TGFb signaling and tumor progression in embryonal rhabdomyosarcoma. Cell Death and Disease 13:419.
  4. Nachiyappan A, Soon J, Lim HJ, Lee VKM, and Taneja R (2022). EHMT1 promotes tumor progression and regulates ALDH1A1 expression in alveolar rhabdomyosarcoma. J Pathology 256:349-362. 
  5. Pal A, Leung JY, Ang GCK, Rao VK, Pignata L, Lim HJ, Hebrard M, Chang KT, Lee VKM, Guccione E, and Taneja R (2020). Deregulation of the histone H3K9 di-methylation landscape suppresses canonical Wnt signaling in embryonal rhabdomyosarcoma. eLife 2020;9:e57683.
  6. Bhat AV, Palanichamy Kala M, Rao VK, Pignata L, Lim HJ, Suriyamurthy S, Chang KTE, Lee VK, Guccione E, Taneja R. Epigenetic regulation of the PTEN-AKT-RAC1 axis by G9a is critical for tumor growth in alveolar rhabdomyosarcoma. Cancer Research 2019 79:2232-2243
  7. Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R*, Tenen DG*. The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nat Commun. 2018 9:1622. *co-corresponding authors
  8. Bharathy N. Suriyamurthy S, Rao Vk, Lim Hj, Chakraborty P, Vasudevan M, Dhamne A, Chang K, Lee V, Kundu T, Taneja R. (2016) P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma. J Pathology 240: 269-281.
  9. Rao VK, Ow JR, Shankar S, Bharathy N, Manikadan J and Taneja R. (2016) G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation. Nucleic Acids Research 44: 8129-8143.
  10. Ling B, Bharathy N, Chung T-K, Kok WK, Li SD, Tan YH, Rao VK, Gopinadhan S, Sartorelli V, Walsh MJ, and Taneja R. Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proc. Natl. Acad. Sci. (USA) 2012. 109:841-846.
  11. Vercherat C, Chung T-K, Yalcin S, Gulbagci N, Gopinadhan S, Ghaffari S and Taneja R. Stra13 regulates oxidative stress mediated skeletal muscle degeneration. Human Molecular Genetics 2009. 18:4304-4316 (featured on journal cover).
  12. Sun H, Li L, Vercherat C, Gulbagci N, Acharjee S, Li J, Chung T-K, Thin T, and Taneja R. Stra13 regulates satellite cell activation by antagonizing Notch signaling. J. Cell Biol. 2007 177:647-57.
  13. Sun H, Lu B, Li R-Q, Flavell RA, and Taneja, R.Defective T-cell activation and autoimmune disorder in Stra13-deficient mice. Nature Immunology 2001. 2:1040-1047.
  14. Sun H and Taneja R.tra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC) dependent and HDAC independent mechanisms. Proc. Natl. Acad. Sci (USA) 2000 97:4058-4063.

Books Edited:
bHLH Transcription Factors in Development and Disease. 2014 (Current Topics in Developmental Biology, Vol. 110). Editor: Reshma Taneja, Publisher: Academic Press, Elsevier Inc
Nuclear Receptors In Development. 2006 (Advances In Developmental Biology, Vol. 16). Editor: Reshma Taneja, Publisher,: Elsevier Press

Awards

  • 2021 Venus International Women’s Award (Distinguished Woman Researcher)
  • 2019 Yong Loo Lin School of Medicine Teaching Excellence Award for AY2018/19
  • 2019 Graduate Mentor of the Year (GRAMAY) Award, Yong Loo Lin School of Medicine, NUS
  • 2018 Faculty Research Excellence Award, Yong Loo Lin School of Medicine, NUS
  • 2014 NGS Teaching Commendation Award
  • 2013 NGS Teaching Commendation Award
  • 2012 Faculty Research Excellence Award, Yong Loo Lin School of Medicine, NUS
  • 2002-2007 Scholar Award, The Leukemia and Lymphoma Society, USA
  • 2001-2002 Charlotte-Geyer Foundation Award, USA
  • 1998-2001 Basil O’Connor Research Award, March of Dimes Birth Defects Foundation, USA
  • 1998-1998 Dean’s Research Incentive Award, USA
  • 1996-1997 University Louis Pasteur Fellowship, France
  • 1995-1996 Bourse de Directeur d’Equipe, Poste Rouge, CNRS, France
  • 1993-1995 Fondation pour la Recherche Medicale, France
  • 1993 Gold Medal, awarded for the best Ph.D. Thesis, Indian Institute of Science, Bangalore
  • 1987-1993 Predoctoral Fellowship, University Grants Commission, India
  • 1984 Gold Medal, awarded for highest university ranking in B.Sc. India.
Scroll to Top