Research Areas of Interest:

Assoc. Professor Mathuru directs the Neurogenetic Models for Human Brain Disorders Lab. He is also Head of Studies of the Life Science Major at Yale-NUS College and is appointed as a Joint Principal Investigator at IMCB, A*STAR where he directs the Mechanisms Underlying Behavior Lab. A/Prof. Mathuru has a lifelong interest in neuroethology and his lab studies neural mechanisms underlying natural behavior motivated by rewards and risks. Their research focuses on applying the insights gained from such studies to model phenotypes associated with human brain disorders, including neurodegeneration, dementia, substance dependence, depression, and anxiety disorders.

Selected Publications

AS Mathuru* Model Organisms: The holy grail of longevity research eLife 11:e85001. 2022, https://doi.org/10.7554/eLife.85001

S Xue*, TTN Ly, RS Vijayakar, J Chen, J Ng, AS Mathuru, F Magdinier & B Reversade* HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature Communications 13, 2022, 3583. https://doi.org/10.1038/s41467-022-31185-8 News Highlight

AS Mathuru*, A Vyas. Social plasticity and decision making. Brain Research, 2022 Jun 15;1785:147890. doi: 10.1016/j.brainres.2022.147890

A Gemmer, K Mirkes, L Anneser, T Eilers, C Kibat,  AS Mathuru, S Ryu, E Schuman Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Scientific Reports 12, 4322. 2022 https://doi.org/10.1038/s41598-022-07990-y

FM Nathan, C Kibat, T Goel, J Stewart, A Claridge-Chang, AS Mathuru* Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference  Addiction Biology, 2022 DOI: https://doi.org/10.1111/adb.13126 News Highlight    

SH Tay, E Elliyana, Y Le, S Menachem, J Ohmer,  AS Mathuru, U Fischer, and C Winkler* A novel zebrafish model for intermediate type spinal muscular atrophy demonstrates the importance of Smn for maintenance of mature motor neurons. Human Molecular Genetics, 2022, DOI: https://doi.org/10.1093/hmg/ddab212  (2021)

PV AshaRani, S Amron, NAB Zainuldin, S Tohari, AYJ  Ng, G Song, B Venkatesh*, and AS Mathuru*. Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study. Journal of Clinical Medicine 2021, DOI: https://doi.org/10.3390/jcm10132810 (2021)

WK Lim**, P  Kaur, H  Huang**, RS  Jo**, A  Ramamoorthy**, LF Ng, J  Suresh, FL  MaishaI, AS Mathuru, NS Tolwinski* Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila. Cellular Molecular Life Science 2021, DOI: https://doi.org/10.1007/s00018-021-03836-4

HH Wong,…[43 authors]…, AS Mathuru, L Ho, F Bard, and B Reversade Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen storage-associated mitochondriopathy, The American Journal of Human Genetics, Available online 25 May 2021, https://www.cell.com/ajhg/fulltext/S0002-9297(21)00187-7

Angela Koh, Shijie Tao, Goh Yun Jing, Vindhya Chaganty, Kelvin See, Kathiresan Purushothaman, László Orbán, Ajay S Mathuru, Thorsten Wohland, Christoph Winkler, A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish, Human Molecular Genetics, ddaa260, 2020, https://doi.org/10.1093/hmg/ddaa260

P Kaur, C Kibat, E Teo, J Gruber, AS Mathuru*, and N Tolwinski*. Use of Optogenetic Amyloid-β to Monitor Protein Aggregation in Drosophila melanogaster, Danio rerio and Caenorhabditis elegans. Bio-protocol 10(23): e3856. 2020, DOI: 10.21769/BioProtoc.3856.

SJ Jesuthasan^#*, S Krishnan^#, RK Cheng, AS Mathuru* Neural correlates of state transitions elicited by a chemosensory danger cue. Progress in Neuropsychopharmacology and Biological Psychiatry, 2020, https://doi.org/10.1016/j.pnpbp.2020.110110

M Vitkauskas and AS Mathuru* Total Recall: Lateral habenula and psychedelics in the study of depression and comorbid brain disorders. International Journal of Molecular Science, 2020, 21(18), 6525; https://doi.org/10.3390/ijms21186525

AS Mathuru*, F Libersat, A Vyas, S Teseo. Why behavioral neuroscience still needs diversity?: A curious case of a persistent need. Neuroscience & Biobehavioral Reviews, 2020, https://doi.org/10.1016a/j.neubiorev.2020.06.021