Research Areas of Interest:

• Cancer progression, with a focus on mechanisms of tumour cell dissemination and survival
• Signaling pathways in cancer and inflammatory diseases
• Education-related research: special interests in medical education & graduate research training

Videos

• Living with Stress: Understanding Stress Physiology and Managing the Effects of Stress on our Minds and Bodies

Selected Publications

• S. Deng, H. C. Leong, A. Datta, V. Gopal, A. P. Kumar and C. T. Yap (2022). PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression. Cancers 2022, 14(7), 1652. doi: 10.3390/cancers14071652.
• S. S. Lee, I.R. Indran, C.T. Yap, D.D. Samarasekera, S.J.Y. Wong, Z.X., Chen (2021). Enhancing the use of peer review and student feedback to evaluate educators in early years of health professions education – insights from a medical school. Singapore Medical Journal, in press.
• J. B. Y. So, R. Kapoor, F. Zhu, C. Koh, L. Zhou, R. Zou, Y. C. Tang, P. C. K. Goo, S. Y. Rha, H. C. Chung, J. Yoong, C. T. Yap, J. Rao, C. K. Chia, S. Tsao, A. Shabbir, J. Lee, K. P. Lam, M. Hartman, W. P. Yong, H. P. Too, and K. G. Yeoh (2021). Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population. Gut. 2021 May; 70(5): 829–837. doi: 10.1136/gutjnl-2020-322065. PMID: 33028667
• M. S. Ong, S. Deng, C. E. Halim, W. Cai, T. Z. Tan, R. U. J. Huang, G. Sethi, S. C. Hooi, A. P. Kumar, C. T. Yap (2020). Cytoskeletal proteins in cancer and intracellular stress: a therapeutic perspective. Cancers (Basel). 2020 Jan 18;12(1):238. doi: 10.3390/cancers12010238. PMID: 31963677
• S. Tavakol, M. Ashrafizadeh, S. Deng, M. Azarian, A. Abdoli, M. Motavaf, D. D. Poormoghadam, H. Khanbabaei, E. G. Afshar, A. Mandegary, A. Pardakhty, C. T. Yap, R. Mohammadinejad, A. P. Kumar (2019). Autophagy modulators: mechanistic aspects and drug delivery systems. Biomolecules. 2019 Sep 25;9(10):530.
  doi: 10.3390/biom9100530. PMID: 31557936
• S. Deng, M. K. Shanmugam, A. P. Kumar, C. T. Yap, G. Sethi, A. Bishayee (2019). Targeting autophagy using natural compounds for cancer prevention and therapy. Cancer. 2019 Apr 15;125(8):1228-1246. doi: 10.1002/cncr.31978. PMID: 30748003
• L. Wang, Y. L. Cho, Y. Tang, J. Wang, J. E. Park, Y. Wu, C. Wang, Y. Tong, R. Chawla, J. Zhang, Y. Shi, S. Deng, G. Lu, Y. Wu, H. W. S. Tan, P. Pawijit, G. G. Y. Lim, H. Y. Chan, J. Zhang, L. Fang, H. Yu, Y. C. Liou, M. Karthik, B. H. Bay, K. L. Lim, S. K. Sze, C. T. Yap, H. M. Shen (2018). PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Res. 2018 Aug;28(8):787-802. doi: 10.1038/s41422-018-0056-0. PMID: 29934616

Other Appointments

• Women in Science and Health (WISH) Executive Committee (2022-2023)

Additional Certifications

• Certified Simulation Instructor, Harvard Medical School, United States (2016)
• Certified Advanced Simulation Instructor, Harvard Medical School, United States (2022)