Research Areas of Interest:

• Targeting chromatin vulnerabilities in cancer
• Identifying epigenetic drivers of therapeutic resistance
• Investigating a role of early-embryonic factor reactivation in cancer cell plasticity
• Regenerative medicine: Exploiting chromatin plasticity to promote developmental potency (e.g. totipotency, stem cells, reprogramming)
• Development and application of (epi)genomic technologies

Selected Publications

• Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer.
  Tan SYX, Zhang J, Tee WW.
  Front Cell Dev Biol. 2022 Jun 8;10:931493. doi: 10.3389/fcell.2022.931493.
• Meiosis initiation: a story of two sexes in all creatures great and small.
  Sou IF, Pryce RM, Tee WW, McClurg UL.
  Biochem J. 2021 Oct 29;478(20):3791-3805. doi: 10.1042/BCJ20210412.
• Transposable Element Dynamics and Regulation during Zygotic Genome Activation in Mammalian Embryos and Embryonic Stem Cell Model Systems.
  Low Y, Tan DEK, Hu Z, Tan SYX, Tee WW.
  Stem Cells Int. 2021 Oct 15;2021:1624669. doi: 10.1155/2021/1624669.
• Retinoic acid induces NELFA-mediated 2C-like state of mouse embryonic stem cells associates with epigenetic modifications and metabolic processes in chemically defined media.
  Wang Y, Na Q, Li X, Tee WW, Wu B, Bao S.
  Cell Prolif. 2021 Jun;54(6):e13049. doi: 10.1111/cpr.13049. Epub 2021 May 7.
• Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells.
  Hu Z, Tan DEK, Chia G, Tan H, Leong HF, Chen BJ, Lau MS, Tan KYS, Bi X, Yang D, Ho YS, Wu B, Bao S, Wong ESM, Tee WW.
  Nat Cell Biol. 2020 Feb;22(2):175-186. doi: 10.1038/s41556-019-0453-8. Epub 2020 Jan 13.
• Enhancers and chromatin structures: regulatory hubs in gene expression and diseases.
  Hu Z, Tee WW.
  Biosci Rep. 2017 Apr 28;37(2). pii: BSR20160183.
• Probing Chromatin Modifications in Response to ERK Signaling.
  Oksuz O, Tee WW.
  Methods Mol Biol. 2017;1487:289-301
• The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression.
  Whittaker DE, Riegman KL, Kasah S, Mohan C, Yu T, Sala BP, Hebaishi H, Caruso A, Marques AC, Michetti C, Smachetti ME, Shah A, Sabbioni M, Kulhanci O, Tee WW, Reinberg D, Scattoni ML, Volk H, McGonnell I, Wardle FC, Fernandes C, Basson MA.
  J Clin Invest. 2017 Mar 1;127(3):874-887.
• Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs.
  Tee WW, Shen SS, Oksuz O, Narendra V, Reinberg D.
  Cell. 2014 Feb 13;156(4):678-90.
• Chromatin features and the epigenetic regulation of pluripotency states in ESCs.
  Tee WW, Reinberg D.
  Development. 2014 Jun;141(12):2376-90.
• Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.
  Tee WW, Pardo M, Theunissen TW, Yu L, Choudhary JS, Hajkova P, Surani MA.
  Genes Dev. 2010 Dec 15;24(24):2772-7.