Manoor Prakash Hande

Manoor Prakash Hande

PhD, MPH

Associate Professor

+65-6516 3664 (Office);
+65-6516 4928 (Lab)

+65-6778 8161

phsmph@nus.edu.sg

Genome Stability Laboratory

ORCID

Affiliations

  • Associate Professor, Department of Physiology, National University of Singapore
  • Assistant Dean, Safety and Research Facilities Management, NUS Medicine

Research Areas of Interest:

  • Radiation Biology – biological response markers of exposure and radiological protection
  • Toxicogenomics and Environmental Toxicology
  • Telomeres and Telomerase in Ageing and Cancer\
  • DNA damage response and repair
  • Interdisciplinary Science Teaching – Science-Technology-Society approach
  • Science Communication

Teaching and Service:

Dr Hande teaches cancer biology and ageing to life sciences students. He taught interdisciplinary seminars such as Biomedicine and Singapore Society and Radiation and Society at Tembusu College, National University of Singapore. During his sabbatical leave from NUS, he was a consultant to the Division of Human Health, International Atomic Energy Agency (IAEA), Vienna, Austria, from 2015 to 2016. Dr Hande was an expert member of the workgroup of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) from 2017 – 2021. Dr Hande has been a member of Committee 1, International Commission on Radiological Protection (ICRP) since July 01, 2021. He is with the ICRP task group 121 on Effects of Ionising radiation exposure in offspring and next generations as Co-Chair and a member of ICRP task group 118 on Relative Biological Effectiveness (RBE), Quality Factor (Q), and Radiation Weighting Factor (wR). He has been a member of the editorial board of Mutation Research – Genetic Toxicology and Environmental Mutagenesis since 2017 and has been an associate editor of the International Journal of Radiation Biology since November 2021. He is now a Regional Editor (acquisition editor) of the journal Mutation Research – Genetic Toxicology and Environmental Mutagenesis since July 2022.

Selected Publications

  1. Ng GYQ and Hande MP† 2024 Use of peptide nucleic acid probe to determine telomere dynamics in improving chromosome analysis in genetic toxicology studies. Mutation Research – Genetic Toxicology and Environmental Mutagenesis 897 https://doi.org/10.1016/j.mrgentox.2024.503773
  2. Shokrollahi M, Stanic M, Hundal A, Chan JNY, Urman D, Hakem A, Garcia RE, Hao J, Maass P, Dickson BC, Hande MP, Pujana MA, Hakem R, Mekhail K 2024 DNA double-strand break-capturing nuclear envelope tubules driving DNA repair. Nature Structural and Molecular Biology (doi: 10.1038/s41594-024-01286-7)
  3. Hande V, Prathaban K, Hande MP† 2022 Educational dialogue on public perception of nuclear radiation. International Journal of Radiation Biology 98(2): 158 – 172 doi: 10.1080/09553002.2022.2009147. (Educational Paper)
  4. Gurung R, Lim HK, Venkatesan S, Lee PSW, Hande MP† 2014 Targeting DNA-PKcs and telomerase in brain tumour cells. Molecular Cancer 13(1): 232  doi: 10.1186/1476-4598-13-232.
  5. AshaRani PV, Low GKM, Hande MP, Valiyaveettil S 2009 Cytotoxic and genotoxic effects of silver nanoparticles in human cells. ACS Nano 3 (2): 279-290, doi: 10.1021/nn800596w (>4000 citations)
  6. McPherson JP, Lemmers B, Chahwan R, …, Hande MP, Hakem R. 2004 Involvement of mammalian Mus81 in genome integrity and tumour suppression. Science 304 (5678): 1822-1826. doi: 10.1126/science.1094557
  7. Hande MP, Azizova TV, Geard CR, Burak LE, Mitchell CR, Khokhryakov VF, Vasilenko FK, Brenner DJ 2003 Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. American Journal of Human Genetics 72 (5): 1162-1170. doi: 10.1086/375041 (Evaluated by Faculty 1000, http://f1000.com/1013213)
  8. d’Adda di Fagagna, F*, Hande MP*, Tong WM, Lansdorp PM, Wang ZQ, Jackson SP 1999 Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nature Genetics 23: 76-80 doi: 10.1038/12680 (Joint first author).
  9. Blasco MA, Lee H-W, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW 1997 Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34 doi: 10.1016/s0092-8674(01)80006-4. (with cover page picture and >2000 citations)
  10. Hande MP, Boei JJWA, Granath F, Natarajan AT 1996 The induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization, I. Dicentrics and Translocations. International Journal of Radiation Biology 69: 437-446 doi: 10.1080/095530096145733

Awards

  • 1991 – 1992 Senior Research Fellowship by Council of Scientific and Industrial Research, Government of India.
  • 1993 - 1994 Monbusho Scholarship, Ministry of Education, Science and Technology, Government of Japan
  • 2001 International Cancer Technology Transfer Fellowships (ICRETT) by the International Union Against Cancer (UICC-Union Internationale Contre le Cancer), Switzerland.
  • 2003 Yamagiwa-Yoshida Memorial International Cancer Study Grant by the International Union Against Cancer (UICC-Union Internationale Contre le Cancer), Switzerland.
  • 2007 Outstanding Mentor Award, Science Mentorship Programme, Ministry of Education, Singapore
  • 2008 Outstanding Mentor Award, Science Mentorship Programme, Ministry of Education, Singapore
  • 2017 - 2021 Expert Member, Workgroup on “Biological mechanisms influencing health effects from low-dose radiation exposure”, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), Vienna, Austria
  • 2021 - 2025 Member, Committee 1 Radiation Effects, International Commission on Radiological Protection (ICRP), Canada
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