Shailaja Seetharaman

Shailaja Seetharaman

Ph.D.

Asisstant Professor

Biography

Shailaja Seetharaman recently joined the Mechanobiology Institute, with a joint appointment as an Assistant Professor in the Department of Physiology, NUS School of Medicine. Prior to this, she was a postdoctoral fellow in the Department of Physics at the University of Chicago. She received her PhD in Cell and Developmental Biology from Institut Pasteur, Paris, and her Master’s in Biomedical and Molecular Sciences from King’s College London. Her work has been supported by the American Heart Association, Eric and Wendy Schmidt AI in Science, and Yen Postdoctoral Fellowships, and the Marie Curie and the Fondation pour la Recherche Médicale PhD Fellowships. Her research will decode the mechano-chemical feedback mechanisms that govern vascular function in health and disease. In particular, her interests lie in understanding how endothelial cells sense and respond to mechanical forces, and how such mechanosensing goes awry to drive cardio- and cerebro-vascular dysfunction in aging and aging-related diseases.

Affiliations

  • Assistant Professor, Department of Physiology, Yong Loo Lin School of Medicine, NUS
  • Principal Investigator, Mechanobiology Institute, NUS

Research Areas of Interest:

  • Cardio- and cerebro-vascular biology – endothelial dysfunction in disease
  • Mechanobiology and biophysics of tissue adaptation
  • AI/ML for cell and tissue mechanobiology

Selected Publications

  1. Seetharaman S, Vianay B, Roca V, Farrugia AJ, De Pascalis C, Boëda B, Dingli F, Loew D, Vassilopoulos S, Bershadsky A, Théry M, Etienne-Manneville S. Microtubules tune mechanosensitive cell responses. Nat Mater. 2022 Mar;21(3):366-377. doi: 10.1038/s41563-021-01108-x. Epub 2021 Oct 18. PMID: 34663953.
  2. Seetharaman S, Etienne-Manneville S. Cytoskeletal Crosstalk in Cell Migration. Trends Cell Biol. 2020 Sep;30(9):720-735. doi: 10.1016/j.tcb.2020.06.004. Epub 2020 Jul 13. PMID: 32674938.
  3. Seetharaman S, Devany J, Kim HR, van Bodegraven E, Chmiel T, Tzu-Pin S, Chou WH, Fang Y, Gardel ML. Mechanosensitive FHL2 tunes endothelial function. bioRxiv [Preprint]. 2024 Jun 17:2024.06.16.599227. doi: 10.1101/2024.06.16.599227. PMID: 38948838; PMCID: PMC11212908.
  4. Bance B, Seetharaman S, Leduc C, Boëda B, Etienne-Manneville S. Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration. J Cell Sci. 2019 Apr 5;132(7):jcs225805. doi: 10.1242/jcs.225805. PMID: 30858195.
  5. De Pascalis C, Pérez-González C, Seetharaman S, Boëda B, Vianay B, Burute M, Leduc C, Borghi N, Trepat X, Etienne-Manneville S. Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts. J Cell Biol. 2018 Sep 3;217(9):3031-3044. doi: 10.1083/jcb.201801162. Epub 2018 Jul 6. PMID: 29980627; PMCID: PMC6122997.

Awards

  • 2025 Presidential Young Professor, National University of Singapore
  • 2025 National Research Foundation Fellowship
  • 2023 Eric and Wendy Schmidt AI in Science Fellowship, Schmidt Sciences
  • 2022 Women in Biology Inclusion Award, WIB Chicago
  • 2022 American Heart Association Postdoc Fellowship
  • 2021 Yen Postdoctoral Fellowship, University of Chicago
  • 2019 Fondation pour la Recherche Médicale PhD Completion Fellowship
  • 2016 Marie SkÅ‚odowska-Curie Actions PhD Fellowship
Scroll to Top