Saji Kumar Sreedharan

For full publication list please refer:
https://pubmed.ncbi.nlm.nih.gov/?term=Sajikumar+S&sort=date

1. Bin Ibrahim, M. Z., & Sajikumar, S. (2024). Exploring New Horizons: Synaptic Tagging and Capture Beyond Space and Time. Synaptic Tagging and Capture: From Synapses to Behavior, (pp. 237-253). Cham: Springer International Publishing.
2. Zhu, Y., Mei, Y., Baby, N., Teo, H. Y., Binte Hanafi, Z., Mohd Salleh, S. N., Sajikumar, S. & Liu, H. (2023). Tumor-mediated microbiota alteration impairs synaptic tagging/capture in the hippocampal CA1 area via IL-1β production. Communications Biology, 6(1), 685.
3. Varma, V. R., Desai, R. J., Navakkode, S., Wong, L. W., Anerillas, C., Loeffler, T., Schilcher, I., Mahesri, M., Chin, K., Horton, D. B., Kim, S. C., Gerhard, T., Segal, J. B., Schneeweiss, S., Gorospe, M., Sajikumar, S., & Thambisetty, M. (2022). Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease. Molecular psychiatry, 10.1038/s41380-022-01912-0. Advance online publication. https://doi.org/10.1038/s41380-022-01912-0
4. Singh, A. K., Neo, S. H., Liwang, C., Pang, K. K. L., Leng, J. C. K., Sinha, S. H., Shetty, M. S., Vasudevan, M., Rao, V. J., Joshi, I., Eswaramoorthy, M., Pavon, M. V., Sheila, A. R., Navakkode, S., Kundu, T. K., & Sajikumar, S. (2022). Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons. Aging cell, 21(9), e13675. https://doi.org/10.1111/acel.13675
5. Navakkode S, Gaunt JR, Pavon MV, Bansal VA, Abraham RP, Chong YS, Ch’ng TH*, Sajikumar S*. (2021). Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer’s disease. Aging Cell. 2021 Nov 18:e13502. doi: 10.1111/acel.13502. Online ahead of print. PMID: 34796608
6. Benoy A, Bin Ibrahim MZ, Behnisch T, Sajikumar S (2021). Metaplastic Reinforcement of Long-Term Potentiation in Hippocampal Area CA2 by Cholinergic Receptor Activation. Journal of Neuroscience. 2021 Nov 3;41(44):9082-9098. doi: 10.1523/JNEUROSCI.2885-20.2021. Epub 2021 Sep 24. PMID: 34561235
7. Wong LW, Chong YS, Lin W, Kisiswa L, Sim E, Ibáñez CF, Sajikumar S (2021). Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor. Aging Cell. 2021 Feb;20(2):e13305. doi: 10.1111/acel.13305. Epub 2021 Jan 15.
8. Krishna-K K, Baby N, Raghuraman R, Navakkode S, Behnisch T, Sajikumar S (2020). Regulation of aberrant proteasome activity re-establishes plasticity and long-term memory in an animal model of Alzheimer’s disease. FASEB J. 2020 May 27. doi: 10.1096/fj.201902844RR.
9. Dasgupta A, Yu Jia L, Krishna K, Baby N, Pang KKL, Benoy A, Behnisch T and Sajikumar S (2020). Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2. Elife. 2020 Apr 20;9:e55344. doi: 10.7554/eLife.55344.
10. Wong LW, Chong YS, Wong WLE, Sajikumar S (2020). Inhibition of Histone Deacetylase Reinstates Hippocampus-Dependent Long-Term Synaptic Plasticity and Associative Memory in Sleep-Deprived Mice. Cereb Cortex. 2020 Jun 1;30(7):4169-4182. doi: 10.1093/cercor/bhaa041.
11. Baby N, Alagappan N, Dheen ST , Sajikumar S (2019). MicroRNA‐134‐5p inhibition rescues long‐term plasticity and synaptic tagging/capture in an Aβ(1–42)‐induced model of Alzheimer’s disease. Aging Cell. 2019 Oct 17:e13046. doi: 10.1111/acel.13046.
12. Pang, K.K.L., Sharma, M., Krishna, K.K., Behnisch, T., Sajikumar, S. (2019). Long-term population spike-timing-dependent plasticity promotes synaptic tagging but not cross-tagging in rat hippocampal area CA1. PNAS. 116(12), 5737-5746.
13. Sharma, M., Sajikumar, S. (2019). G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons. Cerebral Cortex. 29(7), 2932-2946.
14. Wong, L.W., Tann, J.Y., Ibanez, C.F., Sajikumar, S. (2019). The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation. J. Neurosci. 39(28), 5452-5465.
15. Sharma, M., Sajikumar, S. (2018). G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons. Cerebral Cortex. 29(7), 2932-2946.
16. Dasgupta, A., Baby, N., Hakim, M., Wong, Y.P., Behnisch, T., Soong, T.W., Sajikumar, S. (2017) Substance P induces plasticity and synaptic tagging/ capture in rat hippocampal area CA2. PNAS 2017 Jun 30. 114(41), E8741-E8749
17. Sharma, M., Dierkes, T., Sajikumar, S. (2017) Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons. Aging Cell. 16(5), 1062-1072