John Chua Jia En

John Chua Jia En

Dr. rer. nat.

Assistant Professor

+65-6601 5178

phsjcje@nus.edu.sg

Neurodevelopment and degeneration

ORCID

Affiliations

  • Assistant Professor, Department of Physiology, National University of Singapore
  • Healthy Longevity Translational Research Programme, NUS
  • Joint Principal Investigator, IMCB, A*STAR

Research Areas of Interest:

  • Neuronal network establishment and maintenance
  • Neurodevelopmental disorders
  • Neurodegeneration and neuronal aging

Selected Publications

  1. Yu N, Pasha M, Chua JJE. 2024. Redox changes and cellular senescence in Alzheimer’s disease. Redox Biol 70: 103048
  2. Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, et al. 2023. Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses. Biol Psychiatry
  3. Qu Y, Lim JJ, An O, Yang H, Toh YC, Chua JJE. 2023. FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migrations. iScience 26: 108497
  4. Trubetskoy V, Pardinas AF, Qi T, Panagiotaropoulou G, Awasthi S, et al. 2022. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 604: 502-08
  5. Kok VJT, Tang JY, Eng GWL, Tan SY, Chin JTF, et al. 2022. SFPQ promotes RAS-mutant cancer cell growth by modulating 5′-UTR mediated translational control of CK1alpha. NAR Cancer 4: zcac027
  6. Chua JY, Ng SJ, Yagensky O, Wanker EE, Chua JJE. 2021. FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. eNeuro 8
  7. Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, et al. 2019. Increased expression of heme-binding protein 1 early in Alzheimer’s disease is linked to neurotoxicity. eLife 8: e47498
  8. Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, et al. 2019. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron 103: 217-34 e4
  9. Butkevich E, Hartig W, Nikolov M, Erck C, Grosche J, et al. 2016. Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. Scientific reports 6: 26965
  10. Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbruggen G, et al. 2015. The GTPase Rab26 links synaptic vesicles to the autophagy pathway. eLife 4: e05597

Awards

  • 2023 Yong Loo Lin School of Medicine Teaching Excellence Award (Individual)
  • 2022 Yong Loo Lin School of Medicine Graduate Mentor of the Year (GRAMAY) Award
  • 2022 Ng Shi Jun - Outstanding Undergraduate Researcher Prize
  • 2019 Qu Yinghua - Outstanding Talk, SFN-SG meeting Society for Neuroscience, Singapore Chapter Meeting
  • AY2019/2020 Yong Loo Lin School of Medicine Research Excellence Award
  • 2019 Qu Yinghua - Best Short Talk – Neuroscience (11th Models of Physiology and Disease Symposium) NUS, Physiology Department
  • 2019 Lee Jiaqi - Shaw Foundation Scholarship Duke-NUS
  • 2006 Max Planck Research Fellowship Stipend
  • 2000-2003 NUS Graduate Research Scholarship
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