Huang Hua

Huang Hua

PhD

Research Assistant Professor

phshhua@nus.edu.sg

Electrophysiology Core Facility

ORCID

Affiliations

  • Research Assistant Professor, Department of Physiology, National University of Singapore
  • Healthy Longevity Translational Research Programme, NUS

Research Areas of Interest:

  • Ion Channelopathy
  • Patch clamp Electrophysiology
  • Nucleic Acid Therapeutics

Selected Publications

  1. Rajappa, S. et al. The translocation of a chloride channel from the Golgi to the plasma membrane helps plants adapt to salt stress. Nat Commun 15, 3978 (2024).
  2. Nguyen, X. T. A. et al. MFSD7c functions as a transporter of choline at the blood-brain barrier. Cell Res (2024).
  3. Zhai, J. et al. Loss of Ca(V)1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory. Proc Natl Acad Sci U S A 119, e2203883119 (2022).
  4. Hu, Z. et al. S-Nitrosylation-Mediated Reduction of Ca(V)1.2 Surface Expression and Open Probability Underlies Attenuated Vasoconstriction Induced by Nitric Oxide. Hypertension 79, 2854-2866 (2022).
  5. Huang, H., Tay, S. H., Ng, W., Ng, S. Y. & Soong, T. W. Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides. Pain 162, 2097-2109 (2021).
  6. Huang, H. et al. Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Nucleic Acids Res 46, 7323-7338 (2018).
  7. Li, G. et al. Exclusion of alternative exon 33 of Ca(V)1.2 calcium channels in heart is proarrhythmogenic. Proc Natl Acad Sci U S A 114, E4288-E4295 (2017).
  8. Huang, H. et al. Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent. Nat Commun 5, 4481 (2014).
  9. Huang, H., Yu, D. & Soong, T. W. C-terminal alternative splicing of CaV1.3 channels distinctively modulates their dihydropyridine sensitivity. Mol Pharmacol 84, 643-653 (2013).
  10. Huang, H. et al. RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca²⁺-dependent inactivation. Neuron 73, 304-316 (2012).

Awards

  • 2012 Chua Toh Hua Memorial Gold Medal (Life Sciences)
  • 2012, 2015 Swee Liew Wadsworth Gold Award
  • 2012 Poster award, 9th Chinese Symposium on Ca signalling
  • 2013, 2020, 2022 Swee Liew-Wadsworth Research grant
  • 2015 Leopoldina-Travel Grant
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