Research Areas of Interest:

• Epigenetic regulation of skeletal muscle differentiation and regeneration
• Chromatin signalling networks in myopathies

Selected Publications

• Das D, Leung JY, Balamurugan S, Tergaonkar V, Loh A, and Taneja R. (2024). BRD4 isoforms have distinct roles in tumor progression and metastasis in rhabdomyosarcoma. EMBO Reports in press
• Karthik N, Lee J, Soon J, Chiu HY, Loh A, Ong D, Tam WL, Taneja R. (2023). Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma. J Pathology 259(3):342-356
• Chiu HY, Loh A and Taneja R. (2022). MCU dependent mitochondrial calcium uptake regulates TGFb signaling and tumor progression in embryonal rhabdomyosarcoma. Cell Death and Disease 13:419.
• Nachiyappan A, Soon J, Lim HJ, Lee VKM, and Taneja R (2022). EHMT1 promotes tumor progression and regulates ALDH1A1 expression in alveolar rhabdomyosarcoma. J Pathology 256:349-362. 
• Pal A, Leung JY, Ang GCK, Rao VK, Pignata L, Lim HJ, Hebrard M, Chang KT, Lee VKM, Guccione E, and Taneja R (2020). Deregulation of the histone H3K9 di-methylation landscape suppresses canonical Wnt signaling in embryonal rhabdomyosarcoma. eLife 2020;9:e57683.
• Bhat AV, Palanichamy Kala M, Rao VK, Pignata L, Lim HJ, Suriyamurthy S, Chang KTE, Lee VK, Guccione E, Taneja R. Epigenetic regulation of the PTEN-AKT-RAC1 axis by G9a is critical for tumor growth in alveolar rhabdomyosarcoma. Cancer Research 2019 79:2232-2243
• Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R*, Tenen DG*. The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nat Commun. 2018 9:1622. *co-corresponding authors
• Bharathy N. Suriyamurthy S, Rao Vk, Lim Hj, Chakraborty P, Vasudevan M, Dhamne A, Chang K, Lee V, Kundu T, Taneja R. (2016) P/CAF mediates PAX3-FOXO1 dependent oncogenesis in alveolar rhabdomyosarcoma. J Pathology 240: 269-281.
• Rao VK, Ow JR, Shankar S, Bharathy N, Manikadan J and Taneja R. (2016) G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation. Nucleic Acids Research 44: 8129-8143.
• Ling B, Bharathy N, Chung T-K, Kok WK, Li SD, Tan YH, Rao VK, Gopinadhan S, Sartorelli V, Walsh MJ, and Taneja R. Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proc. Natl. Acad. Sci. (USA) 2012. 109:841-846.
• Vercherat C, Chung T-K, Yalcin S, Gulbagci N, Gopinadhan S, Ghaffari S and Taneja R. Stra13 regulates oxidative stress mediated skeletal muscle degeneration. Human Molecular Genetics 2009. 18:4304-4316 (featured on journal cover).
• Sun H, Li L, Vercherat C, Gulbagci N, Acharjee S, Li J, Chung T-K, Thin T, and Taneja R. Stra13 regulates satellite cell activation by antagonizing Notch signaling. J. Cell Biol. 2007 177:647-57.
• Sun H, Lu B, Li R-Q, Flavell RA, and Taneja, R.Defective T-cell activation and autoimmune disorder in Stra13-deficient mice. Nature Immunology 2001. 2:1040-1047.
• Sun H and Taneja R.tra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC) dependent and HDAC independent mechanisms. Proc. Natl. Acad. Sci (USA) 2000 97:4058-4063.

Books Edited:
bHLH Transcription Factors in Development and Disease. 2014 (Current Topics in Developmental Biology, Vol. 110). Editor: Reshma Taneja, Publisher: Academic Press, Elsevier Inc
Nuclear Receptors In Development. 2006 (Advances In Developmental Biology, Vol. 16). Editor: Reshma Taneja, Publisher,: Elsevier Press