Research Areas of Interest:

• Chromosome instability as driver of inflammation in age-related disease
• Extracellular vesicles and therapy-induced senescence
• Impact of aged tumour microenvironment in cancers
• Role of extrachromosomal circular DNA in age-related disease

Selected Publications

Selected Publications

• Matius Robert and Karen Crasta. Breaking the vicious circle: Extrachromosomal circular DNA as an emerging player in tumour evolution. Semin Cell Dev Biol. doi.org/10.1016/j.semcdb.2021.11.015. (2021)
• Karen Crasta. Chromothripsis: A shattered chromosome in the spotlight.
  Semin Cell Dev Biol. doi.org/10.1016/j.semcdb.2021.11.021. Guest Editor for Special Issue on Chromothripsis. (2021)
• JWK Ku, Y Chen, BJW Lim, S Gasser, KC Crasta, YH Gan. Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation. Proceedings of the National Academy of Sciences 117 (27), 15923-15934. (2020)
• VSY Tay, S Devaraj, T Koh, G Ke, KC Crasta, Y Ali. Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis. Scientific Reports 9, 19341. (2019)
• Jakhar R. and Crasta K. Exosomes as emerging pro-tumorigenic mediators of the senescence-associated secretory phenotype. Special Issue: Focus on Exosome-based Cell-Cell Communication in Health and Disease. Int. J. Mol. Sci. 20: 2547. (2019)
• Wong A.X.F., Chen S., Yang L.K., Yoganathan K. and Crasta K.C. Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment. Cell Death Discovery (NPG). 4: 109. (2018)
• P Shyu*, XFA Wong*, K Crasta#, G Thibault#. Dropping in on lipid droplets: insights into cellular stress and cancer. Bioscience Reports 38 (5). (2018)
• He Q., Au B., Kulkarni M., Shen Y., Lim K.J., Maimaiti J., Wong C.K., Luijten M.N.H., Chong H.C.C., Lim E.H., Rancati G., Sinha I., Fu Z., Wang X., Connolly J.E. and Crasta K.C. Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects. Oncogenesis (NPG) 7(8): 62-79. (2018)
• Jakhar R., Luijten M.N.H., Wong A.X.F., Cheng B., Guo K., Neo S.P., Au B., Kulkarni M., Lim K.J., Maimaiti J., Chong H.C., Lim E.H., Tan T.B.K., Ong K.W., Sim Y., Wong J.S.L., Khoo J.B.K., Ho J.T.S., Chua B.T., Sinha I., Wang X., Connolly J.E., Gunaratne J. and Crasta K.C. Autophagy governs pro-tumourigenic effects of mitotic slippage-induced senescence. Mol Can Res (AACR Journal) 16 (11): 1625-1640. (2018).
• Luijten M.N.H., Lee J.X.T. and Crasta K.C. Mutational game changer: chromothripsis and emerging relevance in cancer. Mut Res – Rev Mut Res. 777: 29-51. (2018).
• Monique NH Luijten, Jeannie XT Lee, Sixun Chen, Karen C Crasta. Generation of micronuclei and detection of chromosome pulverization. Chapter 12 pp 183-195. in Chromothripsis. Humana Press, New York, NY. (2018)
• Crasta K# and Aneja R#¬. 50 years on… the discovery of tubulin continues to advance cancer treatment. Endocrine-Related Cancer 24 (9), E3-E5. Invited Guest Editor for Special Issue on “50 years of discovery of Tubulin”. (2017)
• Cheng B. and Crasta K. Consequences of mitotic slippage for anti-microtubule therapy. Endocr Relat Cancer. 24(9): T97-T106. (2017)
• Cheng B. and Crasta K. Autophagy, Cellular Senescence and Cancer. Chapter 4 pp 67-90. in Autophagy and Signaling. CRC Press, Taylor and Francis Group. (2017)
• Crasta K., Ganem N., Dagher R., Lantermann A., Ivanova E., Potopova A., Yunfeng P., Nezi L., Chowdhury D and Pellman D. DNA breaks and chromosome pulverization from errors in mitosis. Nature 482: 53-58. (2012).