Research Theme
Theme Leads
Theme Members
Dr Shruti BHATT
The central focus of research is to identify treatment strategies and underlying mechanisms of therapy-resistant myeloid tumors by studying clonal evolutionary path and cell death mechanisms, particularly the mitochondrial pathway of apoptosis.
Prof Dario CAMPANA
Prof CHNG Wee Joo
Dr CHEONG Jit Kong
Research focus is on uncovering and characterising novel signalling nodes of oncogenic RAS-driven human cancers to facilitate the development of tractable therapeutic modalities.
A/Prof CHEW Suk Peng, Valerie
Research delves into deciphering the intricate immune landscape and crosstalk within the tumor microenvironment of hepatocellular carcinoma (HCC), with a keen focus on uncovering biomarkers and therapeutic avenues.
Dr ENG Wee Ling, Gracie
Research interest focuses on the role of miRNAs as a biomarker for diagnosis and prognosis, and as a potential therapeutic biomolecule in a variety of diseases.
A/Prof Alfredo FRANCO-OBREGON
Dr Anand Devaprasath JEYASEKHARAN
Dr Dennis KAPPEI
Dr Shawn LEE Hsien Ren
Research interests lies in pharmacogenomics and immunogenomics in childhood leukemia; translating these precision modalities into greater personalised therapy to reduce toxicities and improve outcomes in acute leukemias
Dr LIM Si Jing, Joline
Dr Jun Siong LOW
T and B cells are components of the immune system that are essential in fighting against infection-causing “foreign” pathogens, but are also involved in disease settings like cancer and autoimmunity where they can attack “self”. Our lab aims to understand the complex biology of T and B cells at the interplay of infection and cancer, by focusing on their phenotypic and functional profiles, antigen specificities and receptor repertoires. Our long-term goal is to develop rational and effective immune-based therapies to leverage on the immune system to fight cancer.
Dr NGOI Yan Li, Natalie
I am a Medical Oncologist with a keen interest in early drug development and personalized cancer medicine. My research areas of interest surround novel targets, synthetic lethal strategies and associated biomarker discovery for the treatment of Gynecologic Cancers.
Dr OOI Gaik Ming, Melissa
She is currently the leukaemia group lead in National University Cancer Institute of Singapore and is also heavily involved in myeloma, leukaemia and myelodysplasia clinical care and research. She is also interested in health service research and geriatric research.
A/Prof Gautam SETHI
Research focus is to elucidate the mechanism(s) of activation of oncogenic transcription factors and identification of novel inhibitors of these proteins for cancer prevention as well as therapy.
Dr SOON Yu Yang
Research focuses on evidence synthesis and clinical trials. Research goal is to improve health outcomes by synthesizing evidence to evaluate various health interventions to guide clinical practice and inform health policy.
Dr Sriram SRIDHARAN
My research focus is to study how DNA replication is a source of genome instability. I aim to understand why and how the (epi)genome acts as an impediment to faithful DNA replication.
Dr Supriya SRIVASTAVA
Pathologist with a specific focus on solid cancers, particularly gastrointestinal cancers. Research focuses on the identification and validation of biomarkers that aid in the early diagnosis of gastric cancers as well as metaplastic lesions of stomach, that are considered preneoplastic and could be targeted at an early stage thereby improving the patient outcome.
Dr TAI Yee Kit Alex
Research focus is on integrating non-invasive pulsed electromagnetic fields as a complement to conventional chemotherapy to improve treatment outcomes and the quality of life in patients.
Dr TAN Char Loo
Dr TAY Kah Ping, Andy
The research focus of the Tay lab is tissue-specific drug delivery and immunotherapeutics against cancer.
Dr TAY Kai Xun, Joshua
Research interest is in developing gene signatures for precision medicine with full-transcriptome RNA-Seq from small amounts of FFPE tissue.
Prof Daniel TENEN
A/Prof TOO Heng-Phon
A/Prof Balamurugan A VELLAYAPPAN
A/Prof WANG Lingzhi
Prof YEOH Eng Juh, Allen
Dr YONG Wei Peng
Prof Yang ZHANG
Research focus is on cutting-edge artificial intelligence (AI) and deep-learning techniques, we are developing new methods for protein and RNA structure prediction and protein designs. We are particularly interested in the application of the AI-based computational methods for effective cancer therapeutics, with focuses on anti-cancer peptide-drug conjugates (PDCs) and T-cell receptor (TCR)-based adoptive therapy.
Dr ZHOU Jianbiao
Research focus is on the drug resistance mechanisms and aggressive phenotypes in hematologic malignancies, as well as the development predictive markers, novel therapeutic targets.
A/Prof YEOH Eng Juh, Allen
Dr YONG Wei Peng
Prof Yang ZHANG
Research focus is on cutting-edge artificial intelligence (AI) and deep-learning techniques, we are developing new methods for protein and RNA structure prediction and protein designs. We are particularly interested in the application of the AI-based computational methods for effective cancer therapeutics, with focuses on anti-cancer peptide-drug conjugates (PDCs) and T-cell receptor (TCR)-based adoptive therapy.