Calendar
Cell Cycle Dysregulation in Cancer
A study led by Dr Alan Prem Kumar, a member of N2CR, delves into how cancer arises from disruptions in cell cycle regulation, driven by mutations that fuel unchecked division
Spatially Resolved, Tumour Ecosystems in Gastric Cancer Progression
Gastric cancer (GC) has significant global mortality with high heterogeneity. A study of 226 GC samples from 121 patients integrated spatial transcriptomics and single-cell expression profiles, revealing extensive intratumour heterogeneity
Harnessing TME: Breaking Down EMT Barriers in Cancer Treatment
The tumour microenvironment (TME) plays a pivotal role in cancer progression, metastasis, and therapeutic resistance. Comprised of diverse cells, extracellular matrix, and signaling molecules, the TME drives processes like epithelial-mesenchymal
Unveiling p53’s Role in DNA Protection: New Cancer Insights
Research led by N2CR member Dr. Cheok Chit Fang found that the tumour suppressor protein p53 protects DNA during replication by preventing the hyperactivation of PARP1 caused by oxidative stress.
ZBTB48: A New On-Switch for the Immune Response
CIITA is the master regulator of MHC class-II immune genes that are important for defense mechanism against infections and cancer development. CIITA is controlled by three specific switches used in
Magnetic Field Therapy Improves Breast Cancer Treatment with Fewer Side Effects
Chemotherapy, although the first line of defense in cancer treatment, is indiscriminate and is damaging to the entire body, which, ironically, worsens a patient’s chances of getting better from cancer.
director's foreword n2cr
Welcome to the NUS Centre for Cancer Research (N2CR) website!
The N2CR was established in 2020 as one of ten new Translational Research Programmes (TRPs) in the National University of Singapore’s Yong Loo Lin School of Medicine. We are the largest of these Programmes, with over 100 faculty members spanning the basic, translational and clinical sciences.
Professor Ashok Venkitaraman
Director, NUS Centre for Cancer Research
Director, Cancer Science Institute of Singapore
Distinguished Professor of Medicine, Yong Loo Lin School of Medicine, NUS
OUR VISION AND MISSION
of the N2CR is simple
To develop innovative new ways to detect, cure or prevent cancer.
The hallmark of
The Programme
Research Team Of
Tissue-Specific Carcinogenesis
Tissue Specific Carcinogenesis (TSC) focuses on unraveling molecular mechanisms of tissue specific carcinogenesis driving therapy resistance in cancer. The ultimate goal of this Theme is to build an infrastructure and research network that improves how cancer patients are diagnosed, treated and understanding the mechanisms behind therapy resistance in cancer, to identify potential biomarkers of drug resistance/ sensitivity and to identify new targets and treatment modalities to overcome therapy resistance.
A/Prof TAN Shao Peng, David
Theme Lead
Research Team Of
Precision Cancer Medicine
Precision Cancer Medicine (PCM) aims to make diagnosis of cancer simpler and more accurate and ultimately improve treatment. The PCM theme aims to focus research that will identify effective biomarkers, develop new treatment modalities for precision and personalized cancer therapy and create enabling technologies for accurate clinical diagnosis and treatment of specific cancer subtypes and individual cancer patients.
A/Prof CHOW Kai-Hua, Edward
Theme Lead
Research focus is on how to quickly and accurately identify effective cancer therapeutic options for individual cancer patients as well as specific sub-groups of cancer patients in both blood cancers and solid tumours.
Research Team Of
Early Cancer Intervention
Early Cancer Intervention (ECI) focuses on understanding how cell autonomous and non-cell autonomous changes contribute to cancer initiation and relapse post-treatment with the goal of developing innovative approaches to delay, prevent or treat cancer at its earliest stages.
Prof Ashok VENKITARAMAN
Theme Lead
A/Prof Polly CHEN
Theme Lead
some of our trending
News & Events
Discover what matters to you the most.
N2CR recognised by MOE for our Educational Outreach Programme
Nov 13, 2024
Awardees of the Distinguished Senior Clinician Award 2024
Oct 25, 2024
Awardees of the Distinguished Senior Clinician Award 2023
Dec 6, 2023
Yong Loo Lin School of Medicine Excellence Awards for 2023
Jun 27, 2023
A/Prof Polly Chen is nominated as the RNA Society’s Asian Research Ambassador
Apr 28, 2023
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Research Fellow – Dr Shruti Bhatt’s lab
We are seeking a full-time post-doctoral fellow in the leukemia biology laboratory of Dr. Shruti Bhatt in the Department of Pharmacy at the National University of Singapore, Singapore. We are looking for candidates who share our …
Research Fellow – A/Prof Glenn Bonney’s lab
The National University of Singapore invites applications for a Research Fellow position in the Department of Surgery, Yong Loo Lin School of Medicine. The Department of Surgery is a family of 14 sub-specialties that deliver …
Research Fellow – Dr Gloryn Chia’s lab
We are seeking highly motivated Research Fellows with keen interest and expertise in immunology, oncology and/or bioinformatics. Our team aims to leverage on stem cell biology (Sagi, Chia et. al., Nature 2016; Chia et. al., …