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New, collaborative work from researchers’ team led by Dr. Shruti Bhatt at National University of Singapore and Dr. Letai at Dana-Farber Cancer Institute has succeeded in understanding the biology of
A hallmark of cancer cells is the ability to grow indefinitely, which in most tumors depends on the enzyme telomerase. Previous work had shown that the telomerase gene, TERT, is
Social behaviors such as altruism, where one self-sacrifices for collective benefits, critically influence an organism’s survival and responses to the environment. Such behaviors are widely exemplified in nature but have
Intestinal metaplasia (IM), often symptomless, poses a six-fold increased risk of stomach cancer. In this cross-institutional study, co-led by N2CR member Prof Jimmy So, researchers have identified 26 IM driver
Multiple myeloma cells adapt to the harsh bone marrow environment by changing their metabolism. This change affects how the cells use energy and involves a protein called NSD2. Another protein,
Exposure to chemotherapy can change “chemical tags” in our DNA. These tags don’t change the actual DNA, but they can affect how easily the information on DNA is read and used. In
A team of scientists, led by N2CR member Dr. Tee Wee Wei, has identified the enzyme DNA topoisomerase I (TOP1) as a key regulator of gene activity crucial for normal
This study, co-led by A/Prof Takaomi Sanda and A/Prof Allen Yeoh, delves into T-cell acute lymphoblastic leukemia (T-ALL), a difficult to treat form of blood cancer. In T-ALL, the mutated
The PI3K/AKT/mTOR (PAM) signaling pathway is crucial in regulating cell survival, growth, and the cell cycle. Its complex connections with other pathways can lead to cancer when disrupted. This review
Pancreatic cancer is a devastating illness with a poor five-year survival rate. A team of researchers, which includes A/Prof Gautam Sethi, explores the role of autophagy in pancreatic cancer and