Epstein-Barr virus (EBV)-associated smooth muscle tumours (EBV-SMTs) are rare tumours that can arise in immunosuppressed patients. Such patients include those who are post-transplant or have HIV/AIDS or congenital immunodeficiency. However, understanding of EBV-SMTs in terms of its genomic profile is limited, hindering the development of novel treatments for this disease. This study enhances understanding of EBV-SMTs through the characterisation of EBV-SMT copy number alterations, which are modifications in the number of copies of specific DNA sections in the genome. Their findings lay the foundation for the discovery of novel drugs for the treatment of EBV-SMTs.

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