Dr Alan Prem Kumar and his team have discovered a key protein called DP103 that acts like a “master switch,” helping one of the most aggressive forms of breast cancer grow, spread, return after treatment, and resist chemotherapy. By switching off this protein with an investigational drug, researchers were able to dramatically slow cancer growth, reduce the treatment-resistant cells responsible for relapse, prolong survival in animal preclinical studies, and largely spare healthy cells. This breakthrough brings us a step closer to more precise, personalised cancer treatments that target the root cause of disease rather than simply shrinking tumours, offering new hope for patients with difficult-to-treat breast cancers.

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