This research, led by N2CR members Prof Goh Boon Cher and Prof Shazib Pervaiz with Dr Jayshree Hirpara as the first author, investigates the role of extracellular vesicles (EVs) in the tumour microenvironment and its contribution to drug resistance. By isolating and analysing EVs from drug-resistant cells and plasma, the study revealed high levels of metabolic transporters like SLC1A5 which are associated with resistance to Tyrosine Kinase Inhibitors (TKIs), a class of targeted cancer therapy.

The results demonstrated that EVs from resistant cells can induce resistance in sensitive cells and transform fibroblasts into tumour-associated fibroblasts, thereby enhancing their invasive capabilities. These findings highlight the significance of EVs in promoting therapy resistance and suggest potential diagnostic and therapeutic targets.

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