For updated publication list please refer:
https://pubmed.ncbi.nlm.nih.gov/?term=Sajikumar+S&sort=date

1. Bin Ibrahim, M. Z., & Sajikumar, S. (2024). Exploring New Horizons: Synaptic Tagging and Capture Beyond Space and Time. Synaptic Tagging and Capture: From Synapses to Behavior , (pp. 237-253). Cham: Springer International Publishing.
   
2. Zhu, Y., Mei, Y., Baby, N., Teo, H. Y., Binte Hanafi, Z., Mohd Salleh, S. N., Sajikumar, S. & Liu, H. (2023). Tumor-mediated microbiota alteration impairs synaptic tagging/capture in the hippocampal CA1 area via IL-1β production. Communications Biology , 6(1), 685.
   
3. Wang, Z., Kennedy, B. K., Wong, L. W., & Sajikumar, S. (2023). Aging inverts the effects of p75NTR‐modulated mTOR manipulation on hippocampal neuron synaptic plasticity in male mice. The FASEB Journal, 37(8), e23067.
   
4. Raghuraman, R., Navakkode, S., & Sajikumar, S. (2023). Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress. Hippocampus, 33(6), 745-758.
   
5. Pavon, M. V., Navakkode, S., Wong, L. W., & Sajikumar, S. (2023, April). Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's disease. Seminars in cell & developmental biology (Vol. 139, pp. 111-120). Academic Press.
   
6. Varma, V. R., Desai, R. J., Navakkode, S., Wong, L. W., Anerillas, C., Loeffler, T., ... Sajikumar, S. & Thambisetty, M. (2022). Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease. Molecular Psychiatry, 1-15.
   
7. Singh, A. K., Neo, S. H., Liwang, C., Pang, K. K., Leng, J. C., Sinha, S. H., ... & Sajikumar, S. (2022). Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid‐beta 1–42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons. Aging Cell, e13675.
   
8. Zhai, J., Navakkode, S., Yeow, S. Q. Z., Krishna-K, K., Liang, M. C., Koh, J. H., ... & Soong, T. W. (2022). Loss of CaV1. 3 RNA editing enhances mouse hippocampal plasticity, learning, and memory. Proceedings of the National Academy of Sciences, 119(32), e2203883119.
   
9. Benoy, A., Wong, L. W., Ather, N., & Sajikumar, S. (2022). Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats. Oxford Open Neuroscience, 1.
   
10. Pavon, M. V., Navakkode, S., Wong, L. W., & Sajikumar, S. (2022, April). Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's disease. In Seminars in Cell & Developmental Biology. Academic Press.
    
11. Navakkode, S., Ch’ng, T. H., & Sajikumar, S. (2022). Sex matters in Alzheimer’s disease?. Aging (Albany NY), 14(5), 2018.
    
12. Chong, Y. S., Wong, L. W., Gaunt, J., Lee, Y. J., Goh, C. S., Morris, R. G., ... & Sajikumar, S. (2022). Distinct contributions of ventral CA1/amygdala co-activation to the induction and maintenance of synaptic plasticity. Cerebral Cortex.
    
13. Raghuraman, R., Manakkadan, A., Richter-Levin, G., & Sajikumar, S. (2022). Inhibitory metaplasticity in juvenile stressed rats restores associative memory in the adulthood by regulating epigenetic complex G9a/GLP. Int J Neuropsychopharmacol., pyac008.
    
14. Wong, L. W., Wang, Z., Ang, S. R. X., & Sajikumar, S. (2022). Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit? Ageing Res Rev., 101567.
    
15. Navakkode, S., Gaunt, J. R., Pavon, M. V., Bansal, V. A., Abraham, R. P., Chong, Y. S., Ch’ng, T. H., & Sajikumar, S. (2021). Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer's disease. Aging Cell, 20(12), e13502.
    
16. Benoy, A., bin Ibrahim, M. Z., Behnisch, T., & Sajikumar, S. (2021). Metaplastic Reinforcement of Long-Term Potentiation in Hippocampal Area CA2 by Cholinergic Receptor Activation. J. Neurosci., 41(44), 9082-9098.
    
17. bin Ibrahim, M. Z., Benoy, A., & Sajikumar, S. (2021) Long‐Term Plasticity in the Hippocampus: Maintaining Within and ‘Tagging’Between Synapses. The FEBS Journal.
    
18. Lee, J. T. H., Pang, K. K. L., Ang, S. R. X., Sharma, M., & Sajikumar, S. (2021). Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer’s disease. Translational neurodegeneration, 10(1), 1-3.
    
19. Wong, L. W., Chong, Y. S., Lin, W., Kisiswa, L., Sim, E., Ibáñez, C. F., & Sajikumar, S. (2021). Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor. Aging cell, 20(2), e13305.
    
20. Yi, C., Goh, K. Y., Wong, L. W., Ramanujan, A., Tanaka, K., Sajikumar, S., & Ibáñez, C. F. (2021). Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization. The EMBO Journal, 40(2), e104450.
    
21. Ong, W., Marinval, N., Lin, J., Nai, M. H., Chong, Y. S., Pinese, C., ... & Chew, S. Y. (2020). Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP‐Dependent Regulation. Small, 16(37), 2003656.
    
22. Krishna‐K, K., Baby, N., Raghuraman, R., Navakkode, S., Behnisch, T., & Sajikumar, S. (2020). Regulation of aberrant proteasome activity re‐establishes plasticity and long‐term memory in an animal model of Alzheimer's disease. The FASEB Journal, 34(7), 9466-9479.
    
23. Wong, L.W., Chong, Y.S., Wong, W.L.E., Sajikumar, S. (2020) Inhibition of histone deacetylase reinstates hippocampus-dependent long-term synaptic plasticity and associative memory in sleep-deprived mice. Cerebral cortex. bhaa041.
    
24. Baby, N., Alagappan, N., Dheen, S.T., Sajikumar, S. (2019). MicroRNA-134-5p inhibition rescues long-term plasticity and synaptic tagging/capture in an Aβ(1-42)-induced model of Alzheimer’s disease. Aging Cell. 9(1), e13046.
    
25. Saw, G., Krishna, K.K., Gupta, N., Soong, T.W., Mallilankaraman, K., Sajikumar, S., Dheen, S.T. (2019). Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Glia. 68(3), 656-669.
    
26. Mak, A., Dharmadhikari, B., Kow, N.Y., Thamboo, T.P., Tang, Q., Wong, L.W., Sajikumar, S., Wong, H.Y., Schwarz, H. (2019). Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus. Front Immunol. 10, 1411.
    
27. Pang, K.K.L., Sharma, M., Krishna, K.K., Behnisch, T., Sajikumar, S. (2019). Long-term population spike-timing-dependent plasticity promotes synaptic tagging but not cross-tagging in rat hippocampal area CA1. PNAS. 116(12), 5737-5746.
    
28. Pang, K.K.L., Sharma, M., Sajikumar, S. (2019). Epigenetics and memory: Emerging role of histone lysine methyltransferase G9a/GLP complex as bidirectional regulator of synaptic plasticity. Neurobiol Learn Mem. 159, 1-5.
    
29. Raghuraman, R., Karthikeyan, A., Wei, W.L., Dheen, S.T., Sajikumar, S. (2019). Activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area CA1. Neurobiol Learn Mem. 163, 107039.
    
30. Sharma, M., Sajikumar, S. (2019). G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons. Cerebral Cortex. 29(7), 2932-2946.
    
31. Tann, J.Y., Wong, L.W., Sajikumar, S., Ibanez, C.F. (2019). Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing. EMBO J. 38(5).
    
32. Wong, L.W., Tann, J.Y., Ibanez, C.F., Sajikumar, S. (2019). The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation. J. Neurosci. 39(28), 5452-5465.
    
33. Benoy, A., Dasgupta, A., Sajikumar, S. (2018). Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit. Exp Brain Res. 236(4), 919-931.
    
34. Dasgupta, A., Kim, J., Manakkadan, A., Arumugam, T.V., Sajikumar, S. (2018). Intermittent fasting promotes prolonged associative interactions during synaptic tagging/capture by altering the metaplastic properties of the CA1 hippocampal neurons. Neurobiol Learn Mem. 154, 70-77.
    
35. Luo, S.X., Huang, J., Li, Q., Mohammad, H., Lee, C.Y., Krishna, K., Kok, A.M., Tan, Y.L., Lim, J.Y., Li, H., et al. (2018). Regulation of feeding by somatostatin neurons in the tuberal nucleus. Science. 361(6397), 76-81.
    
36. Sharma, M., Raghuraman, R., Sajikumar, S. (2018). Epigenetics: the panacea for cognitive decline? Aging (Albany NY). 10(1), 1-2.
    
37. Sharma, M., Sajikumar, S. (2018). G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons. Cerebral Cortex. 29(7), 2932-2946.
    
38. Dasgupta, A., Baby, N., Hakim, M., Wong, Y.P., Behnisch, T., Soong, T.W., Sajikumar, S. (2017) Substance P induces plasticity and synaptic tagging/ capture in rat hippocampal area CA2. PNAS. 2017 Jun 30. 114(41), E8741-E8749.
    
39. Sharma, M., Dierkes, T., Sajikumar, S. (2017) Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons. Aging Cell. 16(5), 1062-1072.
    
40. Li, Q., Navakkode, S., Rothkegel, M., Soong, T.W., Sajikumar, S., Korte, M. (2017). Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease. PNAS. 114(21), 5527-5532.
    
41. Shetty, M., Sajikumar, S. (2017). 'Tagging' along memories in aging: Synaptic tagging and capture mechanisms in the aged hippocampus. Ageing Res Rev. 35, 22-35.
    
42. Shetty, M.S., Sharma, M., Sajikumar, S. (2016). Chelation of hippocampal zinc enhances long-term potentiation and synaptic tagging/capture in CA1 pyramidal neurons of aged rats: implications to aging and memory. Aging Cell. 16(1), 136-148.
    
43. Yap, K.A., Shetty, M.S., Garcia-Alvarez, G., Lu, B., Alagappan, D., Oh-Hora, M., Sajikumar, S., Fivaz, M. (2016). STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses. Neurobiol Learn Mem. 138, 54-61.
    
44. Shetty, M.S., Sajikumar, S. (2016). Differential involvement of Ca2+/Calmodulin-dependent protein kinases and mitogen-activated protein kinases in the dopamine D1/D5 receptor-mediated potentiation in hippocampal CA1 pyramidal neurons. Neurobiol Learn Mem. 138, 111-120.
    
45. Philips, D.S., Sreejith, S., He, T., Menon, N.V., Anees, P., Mathew, J., Sajikumar, S., Kang, Y., Stuparu, M.C., Sun, H., Zhao, Y., Ajayaghosh, A. (2016). A Three-Photon Active Organic Fluorophore for Deep Tissue Ratiometric Imaging of Intracellular Divalent Zinc. Chem Asian J. 11(10), 1523-1527.
    
46. Chan, E.S., Shetty, M.S., Sajikumar, S., Chen, C., Soong, T.W., Wong, B.S. (2016). ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Scientific Reports. 6(26119).
    
47. Sharma, M., Razali, N.B., Sajikumar, S. (2016). Inhibition of G9a/GLP Complex Promotes Long-Term Potentiation and Synaptic Tagging/Capture in Hippocampal CA1 Pyramidal Neurons. Cerebral Cortex. 27(6), 3161-3171.
    
48. Krishna, K., Behnisch, T., Sajikumar, S. (2016). Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons. Journal of Alzheimer's Disease. 51(3), 783-791.
    
49. Sharma, M., Shetty, M.S., Arumugam, T.V., Sajikumar, S. (2015). Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B. Scientific Reports. 5(16616).
    
50. Shetty, M.S., Sharma, M., Hui, N.S., Dasgupta, A., Gopinadhan, S., Sajikumar, S. (2015). Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from rodents. J. Vis. Exp. (103), e53008, doi:10.3791/53008
    
51. Shetty, M.S., Gopinadhan, S., Sajikumar, S. (2015). Dopamine D1/D5 receptor signalling regulates synaptic cooperation and competition in hippocampal CA1 pyramidal neurons via sustained ERK1/2 activatione. Hippocampus. 26(2), 137-150.
    
52. Li, Q., Korte, M., Sajikumar, S. (2015). Ubiquitin-proteasome system inhibition promotes long-term depression and synaptic tagging /capture. Cerebral Cortex. 26(6), 2541-2548.
    
53. Sharma, M., Sajikumar, S. (2015), Metaplasticity of Synaptic Tagging and Capture: Memory Beyond the Circle, Chapter, Page 197-213, Synaptic Tagging and Capture Book, SPRINGER, New York. 197-213
    
54. Sajikumar, S. (2015) Synaptic Tagging and Capture: From Synapses to Behavior. Editor. SPRINGER, New York. ISBN: 978-1-4939-1760-0 (Print) 978-1-4939-1761-7 (Online)
    
55. Li, Q., Rothkegal, M., Xiao, Z.C., Abraham, W.C., Korte, M., Sajikumar, S. (2014). Making synapses strong: metaplasticity prolongs associativity of long-term memory by switching synaptic tag mechanisms. Cerebral Cortex. 24(2), 353-363.
    
56. Chew, B., Ryu, J.R., Ng, T., Ma, D., Dasgupta, A., Neo, S.H., Zhao, J., Zhong, Z., Bichler, Z., Sajikumar, S., Goh, E.L. (2015). Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity. Front Behav Neurosci. 9(158).
    
57. Garcia-Alvarez, G., Shetty, M.S., Lu, B., Yap, K.A., Oh-Hora, M., Sajikumar, S., Bichler, Z., Fivaz, M. (2015). Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes. Front Behav Neurosci. 9(180).
    
58. Sajikumar, S., Morris, R.G., Korte, M. (2014). Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture. PNAS. 111(33), 12217-12221.
    
59. Navakkode, S., Sajikumar, S., Korte, M., Soong, T.W. (2012). Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels. Learning & Memory. 19(7), 294-299.
    
60. Sajikumar, S., Korte, M. (2011). Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture. Learning & Memory. 18(5), 327-331.
    
61. Sajikumar, S., Korte, M. (2011). Metaplasticity governs compartmentalization of synaptic tagging and capture through BDNF and PKMzeta (PKMζ). PNAS. 108(6), 2551-2556.
    
62. Navakkode, S., Sajikumar, S., Sacktor, T.C., Frey, J.U. (2010) Protein kinase Mzeta is essential for the induction and maintenance of dopamine-induced long-term potentiation in apical CA1 dendrites. Learn Mem. 17(12), 605-611.
    
63. Sajikumar, S.*, Li, Q., Abraham, W.C., Xiao, Z.C. (2009). Priming of short-term potentiation and synaptic tagging/capture mechanisms mediated by ryanodine receptor activation in rat hippocampal CA1. Learn Mem. 16(3), 178-186. (*Corresponding author)
    
64. Yao, Y., Kelly, M.T., Sajikumar, S., Serrano, P., Tian, D., Bergold, P., Frey, J.U., Sacktor, T.C. (2008). PKMzeta maintains late-LTP by enhancing NSF/GluR2-mediated trafficking of postsynaptic AMPARs. J. Neurosci. 28(31), 7820-7827.
    
65. Sajikumar, S., Navakkode, S., Frey, J.U. (2008). Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the CA1. Learn Mem. 15(2), 46-49.
    
66. Sajikumar, S., Navakode, S., Korz, V. Frey, J.U., (2007). Cognitive and emotional information processing: Protein synthesis versus Gene expression. J. Physiol. 584(Pt 2), 389-400.
    
67. Sajikumar, S., Navakkode, S., Frey, J.U. (2007). Identification of compartment- and process-specific molecules required for 'synaptic tagging' during LTP and LTD in hippocampal CA1. J. Neurosci. 27(19), 5068-5080.
    
68. Navakkkode, S., Sajikumar, S., Frey, J.U. (2007). Synergistic requirements for the induction of dopaminergic D1/D5-receptor mediated LTP in hippocampal slices of rat CA1 in vitro. Neuropharmacology. 52(7), 1547-1554.
    
69. Sajikumar, S., Navakkode, S., Frey, J.U. (2005). Protein synthesis-dependent long-term functional plasticity: methods and techniques. Curr. Opin. Neurobiol.15(5), 607-613.
    
70. Navakkode, S., Sajikumar, S., Frey, J.U. (2005). Mitogen-activated protein kinase-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodiesterase inhibitor rolipram and its effect on synaptic tagging. J. Neurosci. 25(46), 10664-10670.
    
71. Sajikumar, S., Navakkode, S., Sacktor, T.C., Frey, J.U. (2005). Synaptic tagging and cross-tagging: the role of protein kinase M zeta in maintaining long-term potentiation, but not long-term depression. J. Neurosci. 25(24), 5750-5756.
    
72. Sajikumar, S., Frey, J.U. (2004). Resetting of 'synaptic tags' is time- and activity-dependent in rat hippocampal CA1 in vitro. Neuroscience. 129(2), 503-507.
    
73. Navakkode, S., Sajikumar, S., Frey, J.U. (2004). The type IV-specific phosphodiesterase inhibitor rolipram and its effect on hippocampal long-term potentiation and synaptic tagging. J. Neuroscience. 24(35), 7740-7744.
    
74. Sajikumar, S., Frey, J.U. (2004). Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD. Neurobiol Learn Mem. 82(1), 12-25.
    
75. Sajikumar, S., Frey, J.U. (2003). Anisomycin inhibits the late maintenance of long-term depression in rat hippocampal slices in vitro. Neurosci Lett. 338(2), 147-150.
    
76. Sajikumar, S., Goel, HC. (2003). Podophyllum hexandrum prevents radiation-induced neuronal damage in postnatal rats exposed in utero. Phytother Res. 2003. 17(7), 761-766.
    
77. Goel, H.C., Sajikumar, S., Sharma, A. (2002). Effects of Podophyllum hexandrum on radiation induced delay of postnatal appearance of reflexes and physiological markers in rats irradiated in utero. Phytomedicine. 2002 Jul; 9(5), 447-454.