Included under the umbrella of University Surgical Cluster, some key research areas and strengths are the generation of minimal invasive endoscopic tools and related intellectual properties. We manufacture biosensors, flow sensors, less invasive surgical retractors and scopes. We also develop methodology to make heart and vascular surgery, more efficient and safer. In the colorectal field, we strive to improve the outcome in colorectal diseases by promoting minimal invasive surgical routes, targeting benign, anorectal disease as well as colorectal cancer. Colorectal cancer, pelvic floor disorders are further priorities, moreover, we use stem cells to address gastric cancer and discover biomarkers for locally advanced gastric cancer. We use Genomic- guided chemotherapy for gastric cancer patients who are at good risks and to address diabetes mellitus and obesity, we explore new Endoluminal Device for Duodenal exclusion for better control in the treatment of Type II diabetes and obesity In Plastic, Reconstructive & Aesthetic Surgery, we pursue scaffold technologies, adult stem cells for tissue regeneration as well as the usage of bio-imaging to better understand pathology & patho-physiology e.g. in facial trauma.
All surgical developments have to aim at reducing patient burden, pain and surgical trauma, to distribute high standards of care to wide masses of the population in the region and the world. Without research and investment in research projects, without research infrastructure and academic commitment, medicine and surgery stagnate. Progress is eliminated. However, diseases spread and change within evolving megatrends, as countries become more industrialized, lifestyle changes and people become older. New pandemics emerge. Without research and innovative surgical therapies many organs, organ systems, human lives cannot be salvaged. It is our vocation, in alignment with the most primary principles of health care, to lead the way to the future with research, teaching and innovation, and hopefully turn scientific concepts of today to useful therapies tomorrow.
The Wang Lab
A multidisciplinary team working on translational research in cardio-metabolic diseases: to discover pathogenic mechanisms, to identify novel therapeutic targets, and to create viable nanomedicines for targeted therapy, with a focus on the heart, the liver, and the gut.
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Our team has been working on cardio-metabolic diseases, cardiac immunology, extracellular vesicles and nanomedicine. Our laboratory is working with various established pre-clinical animal models of human disease, including myocardial infarction, ischemia reperfusion injury, pressure overload, diet-induced heart failure), atherosclerosis and non-alcoholic fatty liver disease. The newly established NANONASH research program aims to tap unto brilliant and young scientists to develop new and effective nanomedicine-based therapies for the treatment of fatty liver disease. Our group also works on new nanomaterials and drug delivery systems (carrying small molecules, nucleic acids, RNAs etc) for translational research in cardiovascular disease, fatty liver disease and gut related disease. Our nanomedicine laboratory, the Centre for NanoMedicine, provides state-of-the-art technology to enable such research and expand the applications of nanomedicine for unmet clinical needs.
BICEPS Laboratory
Developing targeted Magnetic Mitohormesis strategies to improve human health, longevity and physical performance.
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Pioneering changes in clinical management through research.
Development of novel therapies for urological malignancies for bladder cancer and prostate cancer.
Bladder Cancer Workgroup
Our vision is to improve patient care by making
treatments safer and more efficient and developing novel therapies. We aim to
achieve this through rigorous scientific research. Over the last two decades,
the BCW has developed a research program encompassing clinical, translational,
and innovative approaches. Here are some research themes we are currently
working on.
Genetic polymorphisms as a marker of response
to BCG therapy
Alternative treatments for non-muscle invasive
bladder cancer such
as probiotics, nano-drug formulations and implantable devices Disease models of bladder cancer such asorthotopic model and
aging model.
Cancer Initiation and Evolution Laboratory
The Cancer Initiation and Evolution Laboratory (CIEL) is focused on understanding key events which occur along the continuum of normalcy to cancer. This includes the first changes which sets a cell on the path towards eventual cancer, as well as later events which may dictate metastasis or confer onto a cancer unique oncologic phenotypes. Currently, the laboratory has a special interest in colorectal cancer.
Phoenix Lab of Gene and Cell Therapy
Discovery of new and improved methods for treatment of diabetes and other metabolic diseases, such as Laron’s syndrome. Viral Gene Therapy using Adeno-Associated Virus (AAV) and Lentiviral (LV) vectors. Cell therapy using Mesenchymal Stem Cells (MSCs)
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Lee Foundation Programme in the Education of Microbiome
The Lee Foundation Microbiome Education Program has been dedicated to fostering awareness and understanding of the microbiome to the society and it is headed by esteemed mentors Professor Lee Chuen Neng, Associate Professor Shabbir Moochhala and Asst. Prof Jiong-Wei Wang.
moreCardiovascular Single Cell Research Lab
Cellular and Molecular Mechanisms, and
Genetics behind the disease exploration to allow better prevention, prognosis, prediction
behind cardiovascular disease and CVD therapeutic.
The Surgical Proteomics Laboratory (SCALPEL)
SCALPEL was commissioned in February 2018 in the Institute for Health Innovation and technology (iHealthtech), NUS. Using a multidisciplinary approach, our aim is to translate scientific breakthroughs into tangible improvements in patient outcomes. Using a combination of mass spectrometry imaging, proteomics and primary patient derived organiod culture, our research is targeted towards improving the efficacy, safety and precision of chemotherapy, as well as development of mass spectrometry based platforms for real-time pathological and surgical analysis with an emphasis on pancreatic ductal adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC).
Wound Healing and Stem Cell Research Lab
Research and development of novel and affordable biological products for better treatment of non-healing wounds as resulted of aged related diseases
MOreIn 2004,A/Prof Phan invented a new stem cell technology exploiting a Singapore based novel source of stem cells derived from human umbilical cord lining tissue or CLSC tech. 20 years on this technology has proven to be the optimal stem cell tech for cell therapy and regenerative medicine. With the invention, A/Prof Phan's teams have gained a great deal of publications and patents as well as a Singapore based stem cell biotech CellResearch Corp (CRC), which is recognised today as one of most success stories in Singapore and the region. CRC is an employer of more than 50 high income Singapore based workers, a funding source for my research projects and a training hub for both local and overseas students of NUS, NTU, Polytechnics, ITE and high schools for research, innovation and enterprise. CRC is still growing as a significant player in stem cell tech at the global stage and contributing to Singapore development.
RESEARCH: The team stays focus on research and development of novel and affordable biological products for better treatment of non-healing wounds as resulted of aged related diseases and is collaborating with local and international scientists to exploit CLSC tech for other therapies like cancer, diabetes, CVD and neuronal degeneration. INNOVATION: My team and I are still growing our patents portfolio and Singapore based intellectual capital both internally and externally by collaborating with scientists in NUS, Duke-NUS, NTU, A Star, SingHealth. ENTERPRISE: His teams are continuing to grow our Singapore based stem cell biotech CellResearch Corp to be a leading player at the world stage and providing mentorship and advice to NUS and Singapore biotech startups like Cellivate Technologies, Agem Bio and so on.
Professor Theo Kofidis is Head of the Department of Cardiac-, Thoracic- and Vascular Surgery, at the National University Hospital of Singapore, Senior Consultant Cardiothoracic Surgeon, an expert minimally invasive heart surgeon and avid researcher. He is a renowned Cardiac Surgeon and strongly sought-for proctor and surgical teacher around the world. One of only very few AATS members in SE Asia, he is also an Ambassador / Steering Committee of the World Society for Cardiothoracic Surgery for the same region. He is Founder and Owner of the Company Kardia Pte Ltd, aiming at the development of disruptive heart valve- and minimally invasive heart surgery technology. He is Chairman of I.R.I.S. (Initiative for Research and Innovation in Surgery), has introduced various new technologies, and launched new types of less invasive surgery. Over the last 12 years in Singapore, he has established the most complete, pioneering and advanced Minimally Invasive Heart Surgery program in the region, and set up the most advanced hemodynamic research laboratory and Cardiovascular Surgical Research Group in Singapore, with NMRC support.
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