Publications
JOURNAL ARTICLES
2022
Goh, P. S., Roberts-Lieb, S., and Sandars, J. (2022) Micro-Scholarship: An innovative approach for the first steps for Scholarship in Health Professions Education. Medical teacher, pp 1-6. Advance online publication at https://doi.org/10.1080/0142159X.2022.2133689.
Shorey, S., Ang, E., Chua, J., and Goh, P. S. (2022) Coaching interventions among healthcare students in tertiary education to improve mental well-being: A mixed studies review. Nurse education today, 109, 105222. https://doi.org/10.1016/j.nedt.2021.105222
Bhatia SN, Chen X, Dobrovolskaia MA, Lammers T. (2022) Cancer Nanomedicine.Nat Rev Cancer, 22(10):550-6. Epub 2022/08/09. doi: 10.1038/s41568-022-00496-9.
Li B, Zhao M, Lin J, Huang P, Chen X.(2022) Management of Fluorescent Organic/Inorganic Nanohybrids for Biomedical Applications in the Nir-Ii Region. Chem Soc Rev, 51(18):7692-714. Epub 2022/07/22. https://doi.org/10.1039/d2cs00131d
Wu D, Yang K, Zhang Z, Feng Y, Rao L, Chen X, et al. (2022) Metal-Free Bioorthogonal Click Chemistry in Cancer Theranostics. Chem Soc Rev, 51(4):1336-76. Epub 2022/01/21. https://doi.org/10.1039/d1cs00451d
Xue Y, Che J, Ji X, Li Y, Xie J, Chen X. (2022) Recent Advances in Biomaterial-Boosted Adoptive Cell Therapy. Chem Soc Rev, 51(5):1766-94. Epub 2022/02/17. https://doi.org/10.1039/d1cs00786f
Liu C, Liu X, Xiang X, Pang X, Chen S, Zhang Y, et al.(2022) A Nanovaccine for Antigen Self-Presentation and Immunosuppression Reversal as a Personalized Cancer Immunotherapy Strategy. Nat Nanotechnol, 17(5):531-40. Epub 2022/04/13. https://doi.org/10.1038/s41565-022-01098-0
Chen W, Wang Z, Wang L, Chen X. (2022) Smart Chemical Engineering-Based Lightweight and Miniaturized Attachable Systems for Advanced Drug Delivery and Diagnostics. Adv Mater, 34(6):e2106701. Epub 2021/10/14. https://doi.org10.1002/adma.202106701
Hou L, Gong X, Yang J, Zhang H, Yang W, Chen X. (2022) Hybrid-Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy Via Tumor-Associated Macrophages Polarization and Hypoxia Relief. Adv Mater, 34(14):e2200389. Epub 2022/02/02.
Hua Y, Huang JH, Shao ZH, Luo XM, Wang ZY, Liu JQ, et al.(2022) Composition-Dependent Enzyme Mimicking Activity and Radiosensitizing Effect of Bimetallic Clusters to Modulate Tumor Hypoxia for Enhanced Cancer Therapy. Adv Mater, 34(31):e2203734. Epub 2022/06/11. https://doi.org/10.1002/adma.202203734
Ma Y, Su Z, Zhou L, He L, Hou Z, Zou J, et al. (2022) Biodegradable Metal-Organic-Framework-Gated Organosilica for Tumor-Microenvironment-Unlocked Glutathione-Depletion-Enhanced Synergistic Therapy. Adv Mater, 34(12):e2107560. Epub 2021/12/14. https://doi.org/10.1002/adma.202107560.
Wu S-Y, Wu F-G, Chen X. (2022) Antibody-Incorporated Nanomedicines for Cancer Therapy. Advanced Materials, 34(24):2109210. https://doi.org/10.1002/adma.202109210
Wu SY, Wu FG, Chen X. (2022) Antibody-Incorporated Nanomedicines for Cancer Therapy. Adv Mater, 34(24):e2109210. Epub 2022/02/11. https://doi.org/doi:10.1002/adma.202109210
Yang K, Yang Z, Yu G, Nie Z, Wang R, Chen X. (2022) Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy. Adv Mater, 34(6):e2107434. Epub 2021/10/26. https://doi.org/10.1002/adma.202107434
Zhang L, Jiang Z, Yang X, Qian Y, Wang M, Wu S, et al. (2022) Totipotent ""All-in-One"" Peptide Sequentially Blocks Immune Checkpoint and Reverses Immunosuppressive Tumor Microenvironment. Adv Mater, e2207330. Epub 2022/10/20. https://doi.org/10.1002/adma.202207330
Zhang Z, Dalan R, Hu Z, Wang JW, Chew NW, Poh KK, et al. (2022) Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease. Adv Mater, 34(35):e2202169. Epub 2022/04/27. https://doi.org/10.1002/adma.202202169
Huang P, Deng H, Zhou Y, Chen X. (2022) The Roles of Polymers in Mrna Delivery. Matter 5(6):1670-99. https://doi.org/10.1016/j.matt.2022.03.006
Pan Y, Liu L, Rao L, Chen X. (2022) Nanomaterial-Mediated Ablation Therapy for Cancer Stem Cells. Matter, 5(5):1367-90. https://doi.org/10.1016/j.matt.2022.02.015
Huang X, Zha F, Zou J, Li Y, Wang F, Chen X. (2022) Photoacoustic Imaging-Guided Synergistic Photothermal/Radiotherapy Using Plasmonic Bi/Bi2o3−X Nanoparticles. Advanced Functional Materials, 32(23):2113353. https://doi.org/10.1002/adfm.202113353
An L, Wang C, Tian Q, Tao C, Xue F, Yang S, et al. (2022) Nir-Ii Laser-Mediated Photo-Fenton-Like Reaction Via Plasmonic Cu9s8 for Immunotherapy Enhancement. Nano Today, 43:101397. https://doi.org/10.1016/j.nantod.2022.101397
Deng H, Yang Z, Pang X, Zhao C, Tian J, Wang Z, et al. (2022) Self-Sufficient Copper Peroxide Loaded Pka-Tunable Nanoparticles for Lysosome-Mediated Chemodynamic Therapy. Nano Today, 42:101337. https://doi.org/10.1016/j.nantod.2021.101337
Hu H, Zhong D, Li W, Lin X, He J, Sun Y, et al. (2022) Microalgae-Based Bioactive Hydrogel Loaded with Quorum Sensing Inhibitor Promotes Infected Wound Healing. Nano Today, 42:101368. https://doi.org/10.1016/j.nantod.2021.101368
Pan Y, Xu C, Deng H, You Q, Zhao C, Li Y, et al. (2022) Localized Nir-Ii Laser Mediated Chemodynamic Therapy of Glioblastoma.Nano Today, (2022) 43:101435. https://doi.org/10.1016/j.nantod.2022.101435
Yang W, Zhang M, Zhang J, Liu Y, Ning J, Yang J, et al. (2022) In Vivo Activated T Cell Targeting with Pd-1/Pd-L1 Blockade for Sequential Treatment Mediated Cancer Immunotherapy. Nano Today, 44:101492. https://doi.org/10.1016/j.nantod.2022.101492
Li Q, Xu R, Fan H, Xu J, Xu Y, Cao P, et al.(2022) Smart Mushroom-Inspired Imprintable and Lightly Detachable (Mild) Microneedle Patterns for Effective Covid-19 Vaccination and Decentralized Information Storage. ACS Nano, 16(5):7512-24. https://doi.org/10.1021/acsnano.1c10718
Pan Y, Zhu Y, Xu C, Pan C, Shi Y, Zou J, et al. (2022) Biomimetic Yolk-Shell Nanocatalysts for Activatable Dual-Modal-Image-Guided Triple-Augmented Chemodynamic Therapy of Cancer. ACS Nano, Epub 2022/11/01. https://doi.org/10.1021/acsnano.2c08077
Ye Y, He J, Wang H, Li W, Wang Q, Luo C, et al. (2022) Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis. ACS Nano, Epub 2022/10/25. https://doi.org/10.1021/acsnano.2c07444
Zhao C, Deng H, Chen X. (2022) Harnessing Immune Response Using Reactive Oxygen Species-Generating/Eliminating Inorganic Biomaterials for Disease Treatment. Adv Drug Deliv Rev, 188:114456. Epub 2022/07/18. https://doi.org/10.1016/j.addr.2022.114456
Mu J, Li C, Shi Y, Liu G, Zou J, Zhang DY, et al.(2022) Protective Effect of Platinum Nano-Antioxidant and Nitric Oxide against Hepatic Ischemia-Reperfusion Injury. Nat Commun, 13(1):2513. Epub 2022/05/07. https://doi.org/10.1038/s41467-022-29772-w
Tian R, Feng X, Wei L, Dai D, Ma Y, Pan H, et al. (2022) A Genetic Engineering Strategy for Editing near-Infrared-Ii Fluorophores. Nat Commun,13(1):2853. Epub 2022/05/24. https://doi.org/10.1038/s41467-022-30304-9
Wang X, Sun W, Shi H, Ma H, Niu G, Li Y, et al. (2022) Organic Phosphorescent Nanoscintillator for Low-Dose X-Ray-Induced Photodynamic Therapy.Nat Commun, 13(1):5091. Epub 2022/08/31. https://doi.org/10.1038/s41467-022-32054-0
Chan, C. Y., Yuen, V. W., Chiu, D. K., Goh, C. C., Thu, K. L., Cescon, D. W., Soria-Bretones, I., Law, C. T., Cheu, J. W., Lee, D., Tse, A. P., Tan, K. V., Zhang, M. S., Wong, B. P., Wong, C. M., Khong, P. L., Ng, I. O., Bray, M. R., Mak, T. W., Yau, T. C., … Wong, C. C. (2022) Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity. Hepatology https://doi.org/10.1002/hep.32461. Advance online publication
Li B, Liu H, He Y, Zhao M, Ge C, Younis MR, et al. (2022) A “Self-Checking” pH/Viscosity-Activatable NIR-II Molecule for Real-Time Evaluation of Photothermal Therapy Efficacy. Angew Chem Int Ed Engl, 61(16):e202200025. Epub 2022/02/17. https://doi.org/10.1002/anie.202200025
Mu J, Xiao M, Shi Y, Geng X, Li H, Yin Y, et al. (2022) The Chemistry of Organic Contrast Agents in the Nir-Ii Window. Angewandte Chemie International Edition, 61(14):e202114722. https://doi.org/10.1002/anie.202114722
Mu J, Xiao M, Shi Y, Geng X, Li H, Yin Y, et al. (2022) The Chemistry of Organic Contrast Agents in the Nir-Ii Window. Angew Chem Int Ed Engl, 61(14):e202114722. Epub 2021/12/08. https://doi.org/10.1002/anie.202114722
Wang Z, Sun C, Yang K, Chen X, Wang R. (2022) Cucurbituril-Based Supramolecular Polymers for Biomedical Applications. Angew Chem Int Ed Engl, 61(38):e202206763. Epub 2022/06/29. https://doi.org/10.1002/anie.202206763
Zeng F, Tang L, Zhang Q, Shi C, Huang Z, Nijiati S, et al. (2022) Coordinating the Mechanisms of Action of Ferroptosis and the Photothermal Effect for Cancer Theranostics. Angew Chem Int Ed Engl, 61(13):e202112925. Epub 2021/12/22. https://doi.org/10.1002/anie.202112925
Zhao M, Zhuang H, Zhang H, Li B, Ming J, Chen X, et al. (2022) A Lret Nanoplatform Consisting of Lanthanide and Amorphous Manganese Oxide for Nir-Ii Luminescence Lifetime Imaging of Tumor Redox Status. Angew Chem Int Ed Engl, e202209592. Epub 2022/09/30. https://doi.org/10.1002/anie.202209592
Wen X, Shi C, Zeng X, Zhao L, Yao L, Liu Z, et al. (2022) A Paradigm of Cancer Immunotherapy Based on 2-[18f]Fdg and Anti-Pd-L1 Mab Combination to Enhance the Antitumor Effect. Clin Cancer Res, 28(13):2923-37. Epub 2022/03/24. https://doi.org/10.1158/1078-0432.Ccr-22-0159
Chan, C. Y., Chiu, D. K., Yuen, V. W., Law, C. T., Wong, B. P., Thu, K. L., Cescon, D. W., Soria-Bretones, I., Cheu, J. W., Lee, D., Tse, A. P., Zhang, M. S., Tan, K. V., Ng, I. O., Khong, P. L., Yau, T. C., Bray, M. R., Mak, T. W., and Wong, C. C. (2022) CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the United States of America, 119(32), e2119514119. https://doi-org/10.1073/pnas.2119514119
Lu Y, Feng J, Liang Z, Lu X, Guo S, Huang L, et al. (2022) A Tumor Microenvironment Dual Responsive Contrast Agent for Contrary Contrast-Magnetic Resonance Imaging and Specific Chemotherapy of Tumors. Nanoscale Horiz, 7(4):403-13. Epub 2022/02/26. https://doi.org/10.1039/d1nh00632k
Bai L, Hu Z, Han T, Wang Y, Xu J, Jiang G, et al. (2022) Super-Stable Cyanine@Albumin Fluorophore for Enhanced Nir-Ii Bioimaging. Theranostics, 12(10):4536-47. Epub 2022/07/15. https://doi.org/10.7150/thno.71443
Duan H, Ma T, Huang X, Gao B, Zheng L, Chen X, et al. (2022) Avoiding the Self-Nucleation Interference: A Ph-Regulated Gold in Situ Growth Strategy to Enable Ultrasensitive Immunochromatographic Diagnostics. Theranostics, 12(6):2801-10. Epub 2022/04/12. https://doi.org/10.7150/thno.70092
He P, Ren E, Chen B, Chen H, Cheng H, Gao X, et al. (2022) A Super-Stable Homogeneous Lipiodol-Hydrophilic Chemodrug Formulation for Treatment of Hepatocellular Carcinoma. Theranostics 12(4):1769-82. Epub 2022/02/25. https://doi.org/10.7150/thno.68456
Jiang Y, Liu Q, Wang G, Sui H, Wang R, Wang J, et al. (2022) Safety and Efficacy of Peptide Receptor Radionuclide Therapy with (177)Lu-Dota-Eb-Tate in Patients with Metastatic Neuroendocrine Tumors. Theranostics 12(15):6437-45. Epub 2022/10/04. https://doi.org/10.7150/thno.77219
Li M, Zheng X, Han T, Ma S, Wang Y, Sun B, et al. (2022) Near-Infrared-Ii Ratiometric Fluorescence Probes for Non-Invasive Detection and Precise Navigation Surgery of Metastatic Sentinel Lymph Nodes. Theranostics, 12(16):7191-202. Epub 2022/10/25. https://doi.org/10.7150/thno.78085
Wen X, Xu P, Shi M, Liu J, Zeng X, Zhang Y, et al. (2022) Evans Blue-Modified Radiolabeled Fibroblast Activation Protein Inhibitor as Long-Acting Cancer Therapeutics. Theranostics 12(1):422-33. Epub 2022/01/07. https://doi.org/10.7150/thno.68182
Zang J, Wen X, Lin R, Zeng X, Wang C, Shi M, et al. (2022) Synthesis, Preclinical Evaluation and Radiation Dosimetry of a Dual Targeting Pet Tracer [(68)Ga]Ga-Fapi-Rgd. Theranostics, 12(16):7180-90. Epub 2022/10/25. https://doi.org/10.7150/thno.79144
Wen, X., Xu, P., Shi, M., Liu, J., Zeng, X., Zhang, Y., Shi, C., Li, J., Guo, Z., Zhang, X., Khong, P. L., and Chen, X. (2022) Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics. Theranostics, 12(1), 422–433
Zhao C, Pang X, Yang Z, Wang S, Deng H, Chen X. (2022) Nanomaterials Targeting Tumor Associated Macrophages for Cancer Immunotherapy. J Control Release, 341:272-84. Epub 2021/11/24. https://doi.org/10.1016/j.jconrel.2021.11.028
Pang Y, Zhao L, Meng T, Xu W, Lin Q, Wu H, et al. (2022) Pet Imaging of Fibroblast Activation Protein in Various Types of Cancers by Using (68)Ga-Fap-2286:Comparison with (18)F-Fdg and (68)Ga-Fapi-46 in a Single-Center, Prospective Study. J Nucl Med, Epub 2022/10/11. https://doi.org/10.2967/jnumed.122.264544
Schuchardt C, Zhang J, Kulkarni HR, Chen X, Müller D, Baum RP. (2022) Prostate-Specific Membrane Antigen Radioligand Therapy Using (177)Lu-Psma I&T and (177)Lu-Psma-617 in Patients with Metastatic Castration-Resistant Prostate Cancer: Comparison of Safety, Biodistribution, and Dosimetry. J Nucl Med, 63(8):1199-207. Epub 2021/12/11. https://doi.org/10.2967/jnumed.121.262713
Baum, R. P., Schuchardt, C., Singh, A., Chantadisai, M., Robiller, F. C., Zhang, J., Mueller, D., Eismant, A., Almaguel, F., Zboralski, D., Osterkamp, F., Hoehne, A., Reineke, U., Smerling, C., and Kulkarni, H. R. (2022). Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using 177Lu-FAP-2286: First-in-Humans Results. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 63(3), 415–423. https://doi.org/10.2967/jnumed.120.259192
Pang, Y., Zhao, L., Meng, T., Xu, W., Lin, Q., Wu, H., Zhang, J., Chen, X., Sun, L., and Chen, H. (2022). PET imaging of fibroblast activation protein in various types of cancers by using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a single-center, prospective study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, jnumed.122.264544. Advance online publication. https://doi.org/10.2967/jnumed.122.264544
Qiu Q, Huang Y, Zhang B, Huang D, Chen X, Fan Z, et al. (2022) Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (Mmc): A Mouse Study. Environmental Health Perspectives, 130(2):027002. https://doi.org/10.1289/EHP8907
Cui C, Wang C, Fu Q, Song J, Zou J, Li L, et al. (2022) A Generic Self-Assembly Approach Towards Phototheranostics for Nir-Ii Fluorescence Imaging and Phototherapy. Acta Biomaterialia, 140:601-9. https://doi.org/10.1016/j.actbio.2021.11.023
Wu J, Tian J, Zhang Y, Ji H, Sun J, Wang X, et al. (2022) (18)F-Alfatide Ii for the Evaluation of Axillary Lymph Nodes in Breast Cancer Patients: Comparison with (18)F-Fdg. Eur J Nucl Med Mol Imaging, 49(8):2869-76. Epub 2022/02/10. https://doi.org/10.1007/s00259-021-05333-z
Zhao L, Pang Y, Wang Y, Chen J, Zhuang Y, Zhang J, et al.(2022) Somatostatin Receptor Imaging with [68ga]Ga-Dotatate Positron Emission Tomography/Computed Tomography (Pet/Ct) in Patients with Nasopharyngeal Carcinoma. European Journal of Nuclear Medicine and Molecular Imaging, 49(4):1360-73. https://doi.org/10.1007/s00259-021-05587-7
Shi, J., Xue, Z., Tan, K. V., Yuan, H., Tsang, A. C. M., Tsao, S. W., and Khong, P. L. (2022). Longitudinal evaluation of five nasopharyngeal carcinoma animal models on the microPET/MR platform. European journal of nuclear medicine and molecular imaging, 49(5), 1497–1507. https://doi.org/10.1007/s00259-021-05633-4
Kang X, Wang Y, Cai XL, Hua Y, Shao ZH, Chen X, et al. (2022) Chiral Gold Clusters Functionalized Two-Dimensional Nanoparticle Films to Regulate the Adhesion and Differentiation of Stem Cells. J Colloid Interface Sci, 625:831-8. Epub 2022/07/02. https://doi.org/10.1016/j.jcis.2022.06.070
Meng L, Fang J, Zhao L, Wang T, Yuan P, Zhao Z, et al. (2022) Rational Design and Pharmacomodulation of Protein-Binding Theranostic Radioligands for Targeting the Fibroblast Activation Protein. J Med Chem, 65(12):8245-57. Epub 2022/06/07. https://doi.org/10.1021/acs.jmedchem.1c02162
Huang Q, Chen X, Meng QF, Yue L, Jiang W, Zhao XZ, et al.(2022) Microfluidics-Assisted Fluorescence Mapping of DNA Phosphorothioation. Anal Chem, 94(29):10479-86. Epub 2022/07/15. https://doi.org/10.1021/acs.analchem.2c01752
Wang Y, Hua Y, Shao ZH, Chen X, Zhao X, Zang SQ. (2022) Levonorgestrel-Protected Au(8) and Au(10) Clusters with Different Antimicrobial Abilities. J Mater Chem B,10(26):5028-34. Epub 2022/06/21. https://doi.org/10.1039/d2tb00533f
Mo T, Liu X, Luo Y, Zhong L, Zhang Z, Li T, et al. (2022) Aptamer-Based Biosensors and Application in Tumor Theranostics. Cancer Sci, 113(1):7-16. Epub 2021/11/09. https://doi.org/10.1111/cas.15194
Wen X, Zeng X, Liu J, Zhang Y, Shi C, Wu X, et al. (2022) Synergism of (64)Cu-Labeled Rgd with Anti-Pd-L1 Immunotherapy for the Long-Acting Antitumor Effect. Bioconjugate Chemistry, Epub 2022/10/19. https://doi.org/10.1021/acs.bioconjchem.2c00408
Li L, Chen X, Yu J, Yuan S. (2022) Preliminary Clinical Application of Rgd-Containing Peptides as Pet Radiotracers for Imaging Tumors. Front Oncol, 12:837952. Epub 2022/03/22. https://doi.org/10.3389/fonc.2022.837952
Wen X, Zeng X, Cheng X, Zeng X, Liu J, Zhang Y, et al. (2022) Pd-L1-Targeted Radionuclide Therapy Combined with Αpd-L1 Antibody Immunotherapy Synergistically Improves the Antitumor Effect. Mol Pharm, 19(10):3612-22. Epub 2022/06/03. https://doi.org/10.1021/acs.molpharmaceut.2c00281
Wu J, Zhang X, Jia Z, Zhou X, Qi R, Ji H, et al. (2022) Combined (18)F-Fdg and (18)F-Alfatide Ii Pet May Predict Luminal B (Her2 Negative) Subtype and Nonluminal Subtype of Invasive Breast Cancer.Mol Pharm, 19(9):3405-11. Epub 2022/08/17. https://doi.org/10.1021/acs.molpharmaceut.2c00547
Zhang M, Ye J, Xie Z, Wang Y, Ma W, Kang F, et al. (2022)Combined Probe Strategy to Increase the Enzymatic Digestion Rate and Accelerate the Renal Radioactivity Clearance of Peptide Radiotracers. Mol Pharm, 19(5):1548-56. Epub 2022/04/01. https://doi.org/10.1021/acs.molpharmaceut.2c00051
Li B, Lin J, Huang P, Chen X. (2022) Near-Infrared Probes for Luminescence Lifetime Imaging. Nanotheranostics 6(1):91-102. Epub 2022/01/04. https://doi.org/10.7150/ntno.63124
Gandomkar, Z., Khong, P. L., Punch, A., and Lewis, S. (2022). Using Occlusion-Based Saliency Maps to Explain an Artificial Intelligence Tool in Lung Cancer Screening: Agreement Between Radiologists, Labels, and Visual Prompts. Journal of digital imaging, 35(5), 1164–1175.
