Our Publication
(Year 2020)
Alperet DJ, Rebello SA, Khoo EY, Tay Z, Seah SS, Tai BC, Tai ES, Emady-Azar S, Chou CJ, Darimont C, van Dam RM.Am J Clin Nutr. 2020 Feb 1;111(2):448-458. doi: 10.1093/ajcn/nqz306.PMID: 31891374
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer’s and Parkinson’s diseases. Chai JF, Raichur S, Khor IW, Torta F, Chew WS, Herr DR, Ching J, Kovalik JP, Khoo CM, Wenk MR, Tai ES, Sim X. Hum Mol Genet. 2020 Jan 15;29(2):189-201. doi: 10.1093/hmg/ddz246. PMID:31628463
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer’s and Parkinson’s diseases. Chai JF, Raichur S, Khor IW, Torta F, Chew WS, Herr DR, Ching J, Kovalik JP, Khoo CM, Wenk MR, Tai ES, Sim X.Hum Mol Genet. 2020 Jan 15;29(2):189-201. doi: 10.1093/hmg/ddz246.PMID: 31628463
Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function. Ding Q, Tan ALM, Parra EJ, Cruz M, Sim X, Teo YY, Long J, Alsafar H, Petretto E, Tai ES, Chen H.J Hum Genet. 2020 Apr;65(4):411-420. doi: 10.1038/s10038-019-0720-3. Epub 2020 Jan 21.PMID: 31959871
Identification of type 2 diabetes loci in 433,540 East Asian individuals. Spracklen CN, Horikoshi M, Kim YJ, Lin K, Bragg F, Moon S, et al. Nature. 2020 Jun;582(7811):240-245. doi: 10.1038/s41586-020-2263-3. Epub 2020 May 6.PMID: 32499647
The mutational constraint spectrum quantified from variation in 141,456 humans. Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alföldi J, Wang Q, et al. Nature. 2020 May;581(7809):434-443. doi: 10.1038/s41586-020-2308-7. Epub 2020 May 27.PMID: 32461654
Repositioning of the global epicentre of non-optimal cholesterol. NCD Risk Factor Collaboration (NCD-RisC).Nature. 2020 Jun;582(7810):73-77. doi: 10.1038/s41586-020-2338-1. Epub 2020 Jun 3.PMID: 32494083
Cohort profile: the Singapore diabetic cohort study. Luo M, Tan LWL, Sim X, Ng MKH, Van Dam R, Tai ES, Chia KS, Tang WE, Seah DE, Venkataraman K.BMJ Open. 2020 May 30;10(5):e036443. doi: 10.1136/bmjopen-2019-036443.PMID: 32474429
Haematology & Oncology
Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma. de Mel S, Rashid MBM, Zhang XY, Goh J, Lee CT, Poon LM, Chan EHL, Liu X, Chng WJ, Chee YL, Lee J, Yuen YC, Lim JQ, Chia BKH, Laurensia Y, Huang D, Pang WL, Cheah DMZ, Wong EKY, Ong CK, Tang T, Lim ST, Ng SB, Tan SY, Loi HY, Tan LK, Chow EK, Jeyasekharan AD. Blood Cancer J. 2020 Jan 27;10(1):9. doi: 10.1038/s41408-020-0276-7. PMID: 3198828
Immunotherapy in Multiple Myeloma. Soekojo CY, Ooi M, de Mel S, Chng WJ. Cells. 2020 Mar 3;9(3). pii: E601. doi: 10.3390/cells9030601. Review. PMID: 32138182
Qualitative Study of Factors Affecting Patient, Caregiver and Physician Preferences for Treatment of Myeloma and Indolent Lymphoma. Jen WY, Yoong J, Liu X, Tan MSY, Chng WJ, Chee YL. Patient Prefer Adherence. 2020 Feb 17;14:301-308. doi: 10.2147/PPA.S241340. eCollection 2020. PMID: 32109996
Macrophages protect mycoplasma-infected chronic myeloid leukemia cells from natural killer cell killing. Choo QWW, Koean RAG, Chang SC, Chng WJ, Chan MC, Wang W, Er JZ, Ding JL. Immunol Cell Biol. 2020 Feb;98(2):138-151. doi: 10.1111/imcb.12309. Epub 2020 Jan 13. PMID: 31837284
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma. Kong LR, Mohamed Salleh NAB, Ong RW, Tan TZ, Syn NL, Goh RM, Fhu CW, Tan DSW, Iyer NG, Kannan S, Verma CS, Lim YC, Soo R, Ho J, Huang Y, Lim JSJ, Yan BJ, Nga ME, Lim SG, Koeffler HP, Lee SC, Kappei D, Hung HT, Goh BC. Nat Commun. 2020 Mar 25;11(1):1556. doi: 10.1038/s41467-020-15318-5. PMID: 32214092
Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors. Chin TM, Boopathy GTK, Man EPS, Clohessy JG, Csizmadia E, Quinlan MP, Putti T, Wan SC, Xie C, Ali A, Wai FC, Ong YS, Goh BC, Settleman J, Hong W, Levantini E, Tenen DG. Theranostics. 2020 Feb 3;10(6):2727-2743. doi: 10.7150/thno.38729. eCollection 2020. PMID: 32194831
Elevated IL18 levels in Nasopharyngeal carcinoma induced PD-1 expression on NK cells in TILS leading to poor prognosis. Liou AK, Soon G, Tan L, Peng Y, Cher BM, Goh BC, Wang S, Lim CM. Oral Oncol. 2020 Mar 6;104:104616. doi: 0.1016/j.oraloncology.2020.104616. PMID: 32151994
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Fachal L, Aschard H, Beesley J, Barnes DR, Allen J, Kar S, et al. Nat Genet. 2020 Jan;52(1):56-73. doi: 10.1038/s41588-019-0537-1. Epub 2020 Jan 7. PMID: 31911677
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants. Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, et al. Nat Commun. 2020 Mar 5;11(1):1217. doi: 10.1038/s41467-020-15046-w.PMID: 32139696
Incidence of breast cancer attributable to breast density, modifiable and non-modifiable breast cancer risk factors in Singapore. Ho PJ, Lau HSH, Ho WK, Wong FY, Yang Q, Tan KW, Tan MH, Chay WY, Chia KS, Hartman M, Li J.Sci Rep. 2020 Jan 16;10(1):503. doi: 10.1038/s41598-019-57341-7.PMID: 31949192
Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer. Ngoi NYL, Choong C, Lee J, Bellot G, Wong ALA, Goh BC, Pervaiz S. Cancers (Basel). 2020 Mar 2;12(3). pii: E574. doi: 10.3390/cancers12030574. Review. PMID: 32131385
Impact of deviation from guideline recommended treatment on breast cancer survival in Asia. Ho PJ, Ow SGW, Sim Y, Liu J, Lim SH, Tan EY, Tan SM, Lee SC, Tan VK, Yap YS, Chay WY, Tan BKT, Wong FY, Li J, Hartman M.Sci Rep. 2020 Jan 28;10(1):1330. doi: 10.1038/s41598-020-58007-5.PMID: 31992769
Impact of delayed treatment in women diagnosed with breast cancer: A population-based study. Ho PJ, Cook AR, Binte Mohamed Ri NK, Liu J, Li J, Hartman M.Cancer Med. 2020 Apr;9(7):2435-2444. doi: 10.1002/cam4.2830. Epub 2020 Feb 13.PMID: 32053293
Coronary and Cardiovascular Diseases
Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy. Lavenniah A, Luu TDA, Li YP, Lim TB, Jiang J, Ackers-Johnson M, Foo RS.Mol Ther. 2020 Jun 3;28(6):1506-1517. doi: 10.1016/j.ymthe.2020.04.006. Epub 2020 Apr 14.PMID: 32304667
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype. Tan WLW, Anene-Nzelu CG, Wong E, Lee M, Tan HS, Tang SJ, Perrin AMY, Wu KX, Zheng WH, Ashburn RJ, Pan B, Lee MY, Autio MI, Morley M, Tam WL, Cheung C, Margulies KB, Chen L, Cappola TP, Loh M, Chambers J, Prabhakar S, Foo RS.Circ Res. 2020 Jun 12. doi: 10.1161/CIRCRESAHA.120.317254. Online ahead of print.PMID: 32529949
Circles in the heart and cardiovascular system. Lim TB, Lavenniah A, Foo RS.Cardiovasc Res. 2020 Feb 1;116(2):269-278. doi: 10.1093/cvr/cvz227.PMID: 31552406
Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis. Wu Q, Wang J, Tan WLW, Jiang Y, Wang S, Li Q, Yu X, Tan J, Liu S, Zhang P, Tiang Z, Chen Z, Foo RS, Yang HT.Cell Death Dis. 2020 May 11;11(5):354. doi: 10.1038/s41419-020-2508-y.PMID: 32393784
A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. Nguyen NUN, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WLW, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA.Nature. 2020 Jun;582(7811):271-276. doi: 10.1038/s41586-020-2228-6. Epub 2020 Apr 22.PMID: 32499640
E/e’ in relation to outcomes in ST-elevation myocardial infarction. Tai SB, Lau WR, Gao F, Hamid N, Amanullah MR, Fam JM, Yap J, Ewe SH, Chan MY, Yeo KK, Ding ZP, Sahlén A.Echocardiography. 2020 Apr 3. doi: 10.1111/echo.14652. PMID: 32242982
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. Xing M, Ooi WF, Tan J, Qamra A, Lee PH, Li Z, Xu C, Padmanabhan N, Lim JQ, Guo YA, Yao X, Amit M, Ng LM, Sheng T, Wang J, Huang KK, Anene-Nzelu CG, Ho SWT, Ray M, Ma L, Fazzi G, Lim KJ, Wijaya GC, Zhang S, Nandi T, Yan T, Chang MM, Das K, Isa ZFA, Wu J, Poon PSY, Lam YN, Lin JS, Tay ST, Lee MH, Tan ALK, Ong X, White K, Rozen SG, Beer M, Foo RSY, Grabsch HI, Skanderup AJ, Li S, Teh BT, Tan P.J Clin Invest. 2020 Jun 1;130(6):3005-3020. doi: 10.1172/JCI126726.PMID: 32364535
Aldosterone-potassium ratio predicts primary aldosteronism subtype. Puar TH, Loh WJ, Lim DS, Loh LM, Zhang M, Foo RS, Lee L, Swee DS, Khoo J, Tay D, Kam JW, Dekkers T, Velema M, Deinum J, Kek PC.J Hypertens. 2020 Jul;38(7):1375-1383. doi: 10.1097/HJH.0000000000002348.PMID: 31851033
Cardiovascular molecular mechanisms of disease with COVID-19. Foo R, Wang Y, Zimmermann WH, Backs J, Wang DW.J Mol Cell Cardiol. 2020 Apr;141:107. doi: 10.1016/j.yjmcc.2020.04.010. Epub 2020 Apr 11.PMID: 32289321
Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Severe Mitral Regurgitation. Li S, Nguyen NUN, Xiao F, Menendez-Montes I, Nakada Y, Tan WLW, Anene-Nzelu CG, Foo RS, Thet S, Cardoso AC, Wang P, Elhelaly WM, Lam NT, Pereira AHM, Hill JA, Sadek HA.Circulation. 2020 Jun 2;141(22):1787-1799. doi: 10.1161/CIRCULATIONAHA.119.043939. Epub 2020 Apr 10.PMID: 32272846
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. de Las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, et al. Fornage M.Mol Psychiatry. 2020 May 5. doi: 10.1038/s41380-020-0719-3. Online ahead of print.PMID: 32372009
Treating very-long coronary artery disease in the contemporary drug eluting stent era: Single long 48 mm stent versus two overlapping stents showed comparable clinical outcomes. Sim HW, Thong EH, Loh PH, Lee CH, Chan MY, Low AF, Tay EL, Chan KH, Tan HC, Loh JP. Cardiovasc Revasc Med. 2020 Feb 13. pii: S1553-8389(20)30075-0. doi: 10.1016/j.carrev.2020.02.005. PMID: 32085945
Pneumococcal Pneumonia Resembling Acute Myocardial Infarction in an Adolescent Male. Chiong YK, Tan I, Lim TC, Thong WY, Chan MY, Chan SM. Pediatr Infect Dis J. 2020 Jan;39(1):81-84. doi: 10.1097/INF.0000000000002527. PMID: 31725548
Feasibility to Perform T2 * Mapping Postcontrast Administration in Reperfused STEMI Patients for the Detection of Intramyocardial Hemorrhage. Bulluck H, Chowdhury N, Lim MX, Allen JC, Bryant JA, Chan MY, Chan MHH, Chin CWL, Ho HH, Lim ST, Tan RS, Tan JW, Wong PE, Yeo KK, Cook SA, Hausenloy DJ. J Magn Reson Imaging. 2020 Feb;51(2):644-645. doi: 10.1002/jmri.26779. Epub 2019 May 14. No abstract available. PMID: 31087614
Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Yip C, Seneviratna A, Tan SH, Khaing T, Chan SP, Loh J, Lee CH, Low AF, Drum CL, Poh SC, Gibson CM, Ohman EM, Richards AM, Chan MY. J Thromb Thrombolysis. 2020 Feb 19. doi: 10.1007/s11239-020-02066-y. [Epub ahead of print] PMID: 32077007
Computational Fluid Dynamics Modeling of Hemodynamic Parameters in the Human Diseased Aorta: A Systematic Review. Ong CW, Wee I, Syn N, Ng S, Leo HL, Richards AM, Choong AMTL.Ann Vasc Surg. 2020 Feb;63:336-381. doi: 10.1016/j.avsg.2019.04.032. Epub 2019 Jul 22.PMID: 31344467
Transplantation of Endothelial Progenitor Cells in Obese Diabetic Rats Following Myocardial Infarction: Role of Thymosin Beta-4. Poh KK, Lee PSS, Djohan AH, Galupo MJ, Songco GG, Yeo TC, Tan HC, Richards AM, Ye L.Cells. 2020 Apr 12;9(4):949. doi: 10.3390/cells9040949.PMID: 32290541
Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting. Koo CY, Aung AT, Chen Z, Kristanto W, Sim HW, Tam WW, Gochuico CF, Tan KA, Kang GS, Sorokin V, Ong PJL, Kojodjojo P, Richards AM, Tan HC, Kofidis T, Lee CH.Heart. 2020 May 18:heartjnl-2019-316118. doi: 10.1136/heartjnl-2019-316118. Online ahead of print.PMID: 32423904
Have a heart during the COVID-19 crisis: Making the case for cardiac rehabilitation in the face of an ongoing pandemic. Yeo TJ, Wang YL, Low TT.Eur J Prev Cardiol. 2020 Jun;27(9):903-905. doi: 10.1177/2047487320915665. Epub 2020 Apr 1.PMID: 32233671
Accuracy of the 2017 international recommendations for clinicians who interpret adolescent athletes’ ECGs: a cohort study of 11 168 British white and black soccer players. Malhotra A, Dhutia H, Yeo TJ, Finocchiaro G, Gati S, Bulleros P, Fanton Z, Papatheodorou E, Miles C, Keteepe-Arachi T, Basu J, Parry-Williams G, Prakash K, Gray B, D’Silva A, Ensam B, Behr E, Tome M, Papadakis M, Sharma S.Br J Sports Med. 2020 Jun;54(12):739-745. doi: 10.1136/bjsports-2017-098528. Epub 2019 Jul 5.PMID: 31278087
Prevalence of Brugada Syndrome in a Large Population of Young Singaporean Men. Shen X, Tan BYQ, Sia CH, Lee JSW, Dalakoti M, Wang K, Lim DYZ, Sng GGR, Lee ECY, Chow W, Kwan CKW, Wang LK, Tan BY, Lim PCY, Chua KCM, Ho KL, Lim ETS, Ching CK, Teo WS, Chua TSJ, Tan RS, Yeo TJ, Chong DTT.Circulation. 2020 Jan 14;141(2):155-157. doi: 10.1161/CIRCULATIONAHA.119.043670. Epub 2020 Jan 13.PMID: 31928436
Sport and exercise during and beyond the COVID-19 pandemic. Yeo TJ.Eur J Prev Cardiol. 2020 Jun 15:2047487320933260. doi: 10.1177/2047487320933260. Online ahead of print.PMID: 32539555
Screening and treatment of obstructive sleep apnea in acute coronary syndrome. A randomized clinical trial. Koo CY, Chua AP, Kristanto W, Koh EH, Tan ES, Abd Rahman S, Abd Gani MB, Chong JP, Aung AT, Han TO, Chan SP, Low AF, Yeo TC, Chan MY, Kojodjojo P, Richards AM, Lee CH.Int J Cardiol. 2020 Jan 15;299:20-25. doi: 10.1016/j.ijcard.2019.07.003. Epub 2019 Jul 3.PMID: 31307844
Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Yip C, Seneviratna A, Tan SH, Khaing T, Chan SP, Loh J, Lee CH, Low AF, Drum CL, Poh SC, Gibson CM, Ohman EM, Richards AM, Chan MY.J Thromb Thrombolysis. 2020 Feb 19. doi: 10.1007/s11239-020-02066-y. Online ahead of print.PMID: 32077007
Rethinking COVID-19 ‘pneumonia’ – is this primarily a vaso-occlusive disease, and can early anticoagulation save the ventilator famine? Low TT, Cherian R, Lim SL, Chandra B, Tung ML, Kumar SK, Lye P, Chin Xin Yi A, Teo L, Tay EL.Pulm Circ. 2020 Jun 2;10(3):2045894020931702. doi: 10.1177/2045894020931702. eCollection 2020 Jul-Sep.PMID: 32537129
Gastroenterology & Hepatology
Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: the GOASIA study. Pitisuttithum P, Chan WK, Piyachaturawat P, Imajo K, Nakajima A, Seki Y, Kasama K, Kakizaki S, Fan JG, Song MJ, Yoon SK, Dan YY, Lesmana L, Ho KY, Goh KL, Wong VWS, Treeprasertsuk S. BMC Gastroenterol. 2020 Apr 6;20(1):88. doi: 10.1186/s12876-020-01240-z. PMID: 32252638
Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review. Tan EX, Wang MX, Pang J, Lee GH.World J Gastroenterol. 2020 Jan 14;26(2):219-245. doi: 10.3748/wjg.v26.i2.219.PMID: 31988586
Esophageal Melanocytosis in a Patient With Gastroesophagheal Reflux Disease. Koo CS, Wang S, Lee JWJ.Clin Gastroenterol Hepatol. 2020 Feb;18(2):A27-A28. doi: 10.1016/j.cgh.2018.11.044. Epub 2018 Nov 29.PMID: 30502509
Nucleoside analog monotherapy for prophylaxis in Hepatitis B liver transplant patients is safe and efficacious. Muthiah MD, Tan EY, Chua SHM, Huang DQY, Bonney GK, Kow AWC, Lim SG, Dan YY, Tan PS, Lee GH, Lim BL.Hepatol Int. 2020 Jan;14(1):57-69. doi: 10.1007/s12072-019-10011-2. Epub 2020 Jan 10.PMID: 31919678
The efficacy of hepatitis B treatments in achieving HBsAg seroclearance: A systematic review and meta-analysis. Fonseca MA, Ling JZJ, Al-Siyabi O, Co-Tanko V, Chan E, Lim SG. J Viral Hepat. 2020 Mar 14. doi: 10.1111/jvh.13283. [ Review. PMID: 32170983
Gene regulatory network analysis with drug sensitivity reveals synergistic effects of combinatory chemotherapy in gastric cancer. Lee JH, Park YR, Jung M, Lim SG. Sci Rep. 2020 Mar 3;10(1):3932. doi: 10.1038/s41598-020-61016-z. PMID: 32127608
Hepatitis B: Who to treat? A critical review of international guidelines. Huang DQ, Lim SG. Liver Int. 2020 Feb;40 Suppl 1:5-14. doi: 10.1111/liv.14365. Review. PMID: 32077616
Dietary effect of low fish meal aquafeed on gut microbiota in olive flounder (Paralichthys olivaceus) at different growth stages. Niu KM, Lee BJ, Kothari D, Lee WD, Hur SW, Lim SG, Kim KW, Kim KD, Kim NN, Kim SK. Microbiologyopen. 2020 Mar;9(3):e992. doi: 10.1002/mbo3.992. Epub 2020 Jan 11. PMID: 31925997
Ophthalmology
Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases. Seah I, Zhao X, Lin Q, Liu Z, Su SZZ, Yuen YS, Hunziker W, Lingam G, Loh XJ, Su X.Eye (Lond). 2020 Jan 30. doi: 10.1038/s41433-020-0770-y. Online ahead of print.PMID: 32001821
Systemic Factors Associated with Treatment Response in Diabetic Macular Edema. Wong WM, Chee C, Bhargava M, Chai C, Lin H, Zhao P, Ariadarma Mangunkusumo E, Naing T, Yuen YS, Wong TY, Su X, Lingam G.J Ophthalmol. 2020 Mar 19;2020:1875860. doi: 10.1155/2020/1875860. eCollection 2020.PMID: 32280516
A new highly transparent injectable PHA-based thermogelling vitreous substitute. Xue K , Liu Z , Jiang L , Kai D , Li Z , Su X , Loh XJ .Biomater Sci. 2020 Feb 4;8(3):926-936. doi: 10.1039/c9bm01603a.PMID: 31833480
Exploring Factors Underlying Ethnic Difference in Age-related Macular Degeneration Prevalence. Jones M, Whitton C, Tan AG, Holliday EG, Oldmeadow C, Flood VM, Sim X, Chai JF, Hamzah H, Klein R, Teo YY, Mitchell P, Wong TY, Tai ES, Van Dam RM, Attia J, Wang JJ.Ophthalmic Epidemiol. 2020 Jun 8:1-10. doi: 10.1080/09286586.2020.1762229. Online ahead of print.PMID: 32511069
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error. Fan Q, Pozarickij A, Tan NYQ, Guo X, Verhoeven VJM, Vitart V, et al. Commun Biol. 2020 Mar 19;3(1):133. doi: 10.1038/s42003-020-0802-y.PMID: 32193507
Infectious Diseases
Infection, Antibiotics, and Patient Outcomes in the Intensive Care Unit. Yin M, Tambyah PA, Perencevich EN.JAMA. 2020 Mar 24. doi: 10.1001/jama.2020.2241. Online ahead of print.PMID: 32207775
Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases. Tadolini M, Codecasa LR, García-García JM, Blanc FX, Borisov S, Alffenaar JW, et al. Eur Respir J. 2020 May 26:2001398. doi: 10.1183/13993003.01398-2020. Online ahead of print.PMID: 32457198
Next generation sequencing identifies multi-drug resistant herpes simplex virus- associated scrotal ulceration. Mo Y, Lee CK, Loh TP, Koay ESC, Tang JW, Lee CC.J Infect. 2020 Feb;80(2):232-254. doi: 10.1016/j.jinf.2019.10.011. Epub 2019 Oct 18.PMID: 31634492
Acute kidney injury in hospitalized patients with coronavirus disease 2019 (COVID-19): A meta-analysis. Ng JJ, Luo Y, Phua K, Choong AMTL.J Infect. 2020 May 8:S0163-4453(20)30280-2. doi: 10.1016/j.jinf.2020.05.009. Online ahead of print.PMID: 32389782
Thromboembolic events in patients with SARS-CoV-2. Ng JJ, Choong AMTL.J Vasc Surg. 2020 Apr 30:S0741-5214(20)31094-6. doi: 10.1016/j.jvs.2020.04.488. Online ahead of print.PMID: 32360371
Identification of Burkholderia pseudomallei Genes Induced During Infection of Macrophages by Differential Fluorescence Induction. Jitprasutwit S, Jitprasutwit N, Hemsley CM, Onlamoon N, Withatanung P, Muangsombut V, Vattanaviboon P, Stevens JM, Ong C, Stevens MP, Titball RW, Korbsrisate S.Front Microbiol. 2020 Feb 21;11:72. doi: 10.3389/fmicb.2020.00072. eCollection 2020.PMID: 32153515
Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, Zhang Z, You H, Wu M, Zheng Q, Xiong Y, Xiong H, Wang C, Chen C, Xiong F, Zhang Y, Peng Y, Ge S, Zhen B, Yu T, Wang L, Wang H, Liu Y, Chen Y, Mei J, Gao X, Li Z, Gan L, He C, Li Z, Shi Y, Qi Y, Yang J, Tenen DG, Chai L, Mucci LA, Santillana M, Cai H.Cancer Discov. 2020 Jun;10(6):783-791. doi: 10.1158/2159-8290.CD-20-0422. Epub 2020 Apr 28.PMID: 32345594
Obstetrics and Gynaecology
Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study. Tint MT, Sadananthan SA, Soh SE, Aris IM, Michael N, Tan KH, Shek LPC, Yap F, Gluckman PD, Chong YS, Godfrey KM, Velan SS, Chan SY, Eriksson JG, Fortier MV, Zhang C, Lee YS. Am J Clin Nutr. 2020 Mar 27. pii: nqaa055. doi: 10.1093/ajcn/nqaa055. PMID: 32219421
Eating behaviors moderate the associations between risk factors in the first 1000 days and adiposity outcomes at 6 years of age. Fogel A, McCrickerd K, Aris IM, Goh AT, Chong YS, Tan KH, Yap F, Shek LP, Meaney MJ, Broekman BFP, Godfrey KM, Chong MFF, Cai S, Pang WW, Yuan WL, Lee YS, Forde CG. Am J Clin Nutr. 2020 Mar 27. pii: nqaa052. doi: 10.1093/ajcn/nqaa052. [PMID: 32219418
Is breastfeeding associated with later child eating behaviours? Pang WW, McCrickerd K, Quah PL, Fogel A, Aris IM, Yuan WL, Fok D, Chua MC, Lim SB, Shek LP, Chan SY, Tan KH, Yap F, Godfrey KM, Meaney MJ, Wlodek ME, Eriksson JG, Kramer MS, Forde CG, Chong MF, Chong YS. Appetite. 2020 Mar 7;150:104653. doi: 10.1016/j.appet.2020.104653. PMID: 32151607
Maternal antenatal anxiety and electrophysiological functioning amongst a sub-set of preschoolers participating in the GUSTO cohort. Tan HK, Goh SKY, Tsotsi S, Bruntraeger M, Chen HY, Broekman B, Tan KH, Chong YS, Meaney MJ, Qiu A, Rifkin-Graboi A. BMC Psychiatry. 2020 Feb 12;20(1):62. doi: 10.1186/s12888-020-2454-3. PMID: 32050929
Associations between early-life screen viewing and 24 hour movement behaviours: findings from a longitudinal birth cohort study. Chen B, Bernard JY, Padmapriya N, Ning Y, Cai S, Lança C, Tan KH, Yap F, Chong YS, Shek L, Godfrey KM, Saw SM, Chan SY, Eriksson JG, Tan CS, Müller-Riemenschneider F. Lancet Child Adolesc Health. 2020 Mar;4(3):201-209. doi: 10.1016/S2352-4642(19)30424-9. PMID: 32004497
Nutrients or nursing? Understanding how breast milk feeding affects child cognition. Pang WW, Tan PT, Cai S, Fok D, Chua MC, Lim SB, Shek LP, Chan SY, Tan KH, Yap F, Gluckman PD, Godfrey KM, Meaney MJ, Broekman BFP, Kramer MS, Chong YS, Rifkin-Graboi A.Eur J Nutr. 2020 Mar;59(2):609-619. doi: 10.1007/s00394-019-01929-2. Epub 2019 Feb 26.PMID: 30809702
Influences of the perinatal diet on maternal and child health: insights from the GUSTO study. Chong MF, Godfrey KM, Gluckman P, Tan KH, Shek LP, Meaney M, Chan JKY, Yap F, Lee YS, Chong YS. Proc Nutr Soc. 2020 Jan 24:1-6. doi: 10.1017/S0029665119001526. PMID: 31973784
Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study. Lai JS, Veetil VO, Lanca C, Lee BL, Godfrey KM, Gluckman PD, Shek LP, Yap F, Tan KH, Chong YS, Ong CN, Ngo CS, Saw SM, Chong MFF. Nutrients. 2020 Jan 21;12(2). pii: E274. doi: 10.3390/nu12020274. PMID: 31972973
Association between maternal carotenoid, vitamin A, and vitamin E levels and allergic outcomes in the offspring in the first 5 years of life. Loo EXL, Zhu Y, Lai JS, Chan YH, Ong CN, Tham EH, Goh A, Teoh OH, Tan KH, Yap F, Chong YS, Gluckman PD, Godfrey KM, Van Bever H, Lee BW, Chong MF, Shek LP.Pediatr Allergy Immunol. 2020 Jan;31(1):95-97. doi: 10.1111/pai.13122. Epub 2019 Oct 9. PMID: 31532016
Drug Discovery, Development and Precision Medicine
Navigating conflicts of justice in the use of race and ethnicity in precision medicine. Schaefer GO, Tai ES, Sun SH.Bioethics. 2020 May 19. doi: 10.1111/bioe.12757. Online ahead of print.PMID: 32426883
Enabling Technologies for Personalized and Precision Medicine. Ho D, Quake SR, McCabe ERB, Chng WJ, Chow EK, Ding X, Gelb BD, Ginsburg GS, Hassenstab J, Ho CM, Mobley WC, Nolan GP, Rosen ST, Tan P, Yen Y, Zarrinpar A. Trends Biotechnol. 2020 Jan 21. pii: S0167-7799(19)30316-6. doi: 10.1016/j.tibtech.2019.12.021. [Epub ahead of print] Review. PMID: 31980301
1Phase I trial of expanded, activated autologous NK cell infusions with trastuzumab in patients with HER2-positive cancers. Lee SC, Shimasaki N, Lim JSJ, Wong AL, Yadav K, Yong WP, Tan LK, Koh LP, Poon MLM, Tan SH, Ow SG, Bharwani L, Yap YS, Foo M, Coustan-Smith E, Sundar R, Tan HL, Chong WQ, Kumarakulasinghe NB, Lieow JLM, Koe PJX, Goh BC, Campana D.Clin Cancer Res. 2020 Jun 10:clincanres.0768.2020. doi: 10.1158/1078-0432.CCR-20-0768. Online ahead of print.PMID: 32522887
Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors. Chin TM, Boopathy GTK, Man EPS, Clohessy JG, Csizmadia E, Quinlan MP, Putti T, Wan SC, Xie C, Ali A, Wai FC, Ong YS, Goh BC, Settleman J, Hong W, Levantini E, Tenen DG.Theranostics. 2020 Feb 3;10(6):2727-2743. doi: 10.7150/thno.38729. eCollection 2020.PMID: 32194831
Oral administration of protein nanoparticles: An emerging route to disease treatment. Sadeghi S, Lee WK, Kong SN, Shetty A, Drum CL.Pharmacol Res. 2020 Feb 22;158:104685. doi: 10.1016/j.phrs.2020.104685. Online ahead of print.PMID: 32097749 Review.
Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. Wang W, Xiang P, Chew WS, Torta F, Bandla A, Lopez V, Seow WL, Lam BWS, Chang JK, Wong P, Chayaburakul K, Ong WY, Wenk MR, Sundar R, Herr DR.J Biol Chem. 2020 Jan 24;295(4):1143-1152. doi: 10.1074/jbc.RA119.011699. Epub 2019 Dec 27.PMID: 31882542
Pharmacology and Therapeutics
A unique CDK4/6 inhibitor: current and future therapeutic strategies of abemaciclib. Chong QY, Kok ZH, Bui NL, Xiang X, Li-Ann Wong A, Peng Yong W, Sethi G, Lobie PE, Wang L, Goh BC. Pharmacol Res. 2020 Feb 14:104686. doi: 10.1016/j.phrs.2020.104686. [Epub ahead of print] Review. PMID: 32068118
Redefining chemotherapy-induced peripheral neuropathy through symptom cluster analysis and patient-reported outcome data over time. Wang M, Cheng HL, Lopez V, Sundar R, Yorke J, Molassiotis A.BMC Cancer. 2019 Nov 27;19(1):1151. doi: 10.1186/s12885-019-6352-3.PMID: 31775665
Venom natriuretic peptides guide the design of heart failure therapeutics. Sridharan S, Kini RM, Richards AM.Pharmacol Res. 2020 May;155:104687. doi: 10.1016/j.phrs.2020.104687. Epub 2020 Feb 11.PMID: 32057893
Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations. Sheu WHH, Chan SP, Matawaran BJ, Deerochanawong C, Mithal A, Chan J, Suastika K, Khoo CM, Nguyen HM, Linong J, Luk A, Yoon KH. Diabetes Metab J. 2020 Feb;44(1):11-32. doi: 10.4093/dmj.2019.0208. Review. PMID: 32097996
Biotherapeutic Approaches in Atopic Dermatitis. Tham EH, Koh E, Common JEA, Hwang IY.Biotechnol J. 2020 Mar 16:e1900322. doi: 10.1002/biot.201900322. Online ahead of print.PMID: 32176834
Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma. Dimopoulos MA, Jakubowiak AJ, McCarthy PL, Orlowski RZ, Attal M, Bladé J, Goldschmidt H, Weisel KC, Ramasamy K, Zweegman S, Spencer A, Huang JSY, Lu J, Sunami K, Iida S, Chng WJ, Holstein SA, Rocci A, Skacel T, Labotka R, Palumbo A, Anderson KC. Blood Cancer J. 2020 Feb 13;10(2):17. doi: 10.1038/s41408-020-0273-x. Review. PMID: 32054831
Surgery
Maternal and fetal outcomes of Asian pregnancies after bariatric surgery. Malik S, Teh JL, Lomanto D, Kim G, So JB, Shabbir A.Surg Obes Relat Dis. 2020 Apr;16(4):529-535. doi: 10.1016/j.soard.2020.01.017. Epub 2020 Jan 23.PMID: 32085937
Successful endovascular management of multiple mycotic aneurysms after liver transplantation – A case report and review of the literature. Ng JJ, Tan JKH, Wong JCL, Wee BBK, Shridhar IG, Kow AWC, Madhavan K, Mangat KS, Bonney GK.Vascular. 2020 Apr;28(2):165-171. doi: 10.1177/1708538119890963. Epub 2019 Dec 10.PMID: 31821777
A proposed scoring system for triaging patients who require vascular access creation in times of COVID-19. Ng JJ, Ngoh CLY, Choong AMTL.J Vasc Surg. 2020 Jun 9:S0741-5214(20)31316-1. doi: 10.1016/j.jvs.2020.05.057. Online ahead of print.PMID: 32531319
Nasal Cavity Metastasis From Colorectal Cancer Represents End-Stage Disease and Should Be Palliated. Hwang S, Chan DKH, Petersson F, Tan KK.Ann Coloproctol. 2020 Apr;36(2):119-121. doi: 10.3393/ac.2019.03.04. Epub 2019 Nov 13.PMID: 32054259
A Case of a Rare Ischiorectal Fossa Mass. Tan IJ, Thian YL, Tan KK.J Gastrointest Surg. 2020 May 4. doi: 10.1007/s11605-020-04595-6. Online ahead of print.PMID: 32367281
Avoiding collateral mortality in a pandemic – time to change our mindset in surgical oncology. Tan KK, Moran BJ, Solomon MJ.Nat Rev Clin Oncol. 2020 May 5:1-3. doi: 10.1038/s41571-020-0383-1. Online ahead of print.PMID: 32372035
Experience from a Singapore tertiary hospital with restructuring a vascular surgery practice in response to national and institutional policies during the COVID-19 pandemic. Ng JJ, Gan TRX, Niam JY, Menon RK, Ho P, Dharmaraj RB, Wong JCL, Choong AMTL.J Vasc Surg. 2020 May 23:S0741-5214(20)31281-7. doi: 10.1016/j.jvs.2020.05.026. Online ahead of print.PMID: 32454232
Laparoscopic gastrectomy and metastasectomy for stage IV gastric cancer. Min SH, Won Y, Lee K, Youn SI, Kim G, Park YS, Ahn SH, Park DJ, Kim HH.Surg Endosc. 2020 Apr 27. doi: 10.1007/s00464-020-07592-7. Online ahead of print.PMID: 32342215
Effect of bariatric surgery on glycemic profiles in multiethnic obese nondiabetic Asians. Teh JL, Leong WQ, Tan YZ, So JB, Kim G, Shabbir A.Surg Obes Relat Dis. 2020 Mar;16(3):422-430. doi: 10.1016/j.soard.2019.11.017. Epub 2019 Dec 3.PMID: 31954632
Letter by Ng and Choong Regarding Article, “Absence of Long-Term Benefit of Revascularization in Patients With Intermittent Claudication: Five-Year Results From the IRONIC Randomized Controlled Trial”. Ng JJ, Choong AMTL.Circ Cardiovasc Interv. 2020 Jun;13(6):e009322. doi: 10.1161/CIRCINTERVENTIONS.120.009322. Epub 2020 Jun 10.PMID: 32519891
Robot-Assisted Endoscopic Resection: Current Status and Future Directions. Kaan HL, Ho KY.Gut Liver. 2020 Mar 15;14(2):150-152. doi: 10.5009/gnl19047.PMID: 31158954
Endoscopic Full Thickness Resection for Gastrointestinal Tumors – Challenges and Solutions. Kaan HL, Ho KY. Clin Endosc. 2020 Feb 17. doi: 10.5946/ce.2019.161. Online ahead of print.PMID: 32061203
First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity. Kaan HL, Phan PT, Tiong AMH, Miyasaka M, Phee SJ, Ho KY.Endosc Int Open. 2020 May;8(5):E607-E610. doi: 10.1055/a-1127-2991. Epub 2020 Apr 17.PMID: 32355877
A Rare Case of Ileocecal Valve Stricture. Jse-Wei TI, Tan KK.Gastroenterology. 2020 Apr 17:S0016-5085(20)30507-2. doi: 10.1053/j.gastro.2020.04.024. Online ahead of print.PMID: 32311365
Laparoscopic gastrectomy and metastasectomy for stage IV gastric cancer. Min SH, Won Y, Lee K, Youn SI, Kim G, Park YS, Ahn SH, Park DJ, Kim HH.Surg Endosc. 2020 Apr 27. doi: 10.1007/s00464-020-07592-7. Online ahead of print.PMID: 32342215
Dermatology
Malassezia: a case of coexisting pityriasis versicolor and Malassezia folliculitis. Choi E, Tan CL, Aw D.Singapore Med J. 2020 Apr;61(4):221. doi: 10.11622/smedj.2018079. Epub 2018 Jun 21.PMID: 29926112
Efficacy of Targeted Education In Reducing Topical Steroid Phobia, A Randomised Clinical Trial. Choi E, Tan KW, Tang F, Tan C, Chandran NS.J Am Acad Dermatol. 2020 Mar 11:S0190-9622(20)30389-3. doi: 10.1016/j.jaad.2020.02.079. Online ahead of print.PMID: 32171815
Patient characteristics, expectations and willingness to pay for hair loss therapies: A survey of 1561 participants at a tertiary dermatological referral centre in Singapore. Choi EC, Zhao X, Lee JS, Wang EC.Australas J Dermatol. 2020 May 18. doi: 10.1111/ajd.13329. Online ahead of print.PMID: 32424817
Corticosteroid phobia: a questionnaire study using TOPICOP score. Choi E, Chandran NS, Tan C.Singapore Med J. 2020 Mar;61(3):149-153. doi: 10.11622/smedj.2019110. Epub 2019 Sep 19.PMID: 32488277
Pathology
Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach. Hue SS, Oon ML, Wang S, Tan SY, Ng SB.Pathology. 2020 Jan;52(1):111-127. doi: 10.1016/j.pathol.2019.09.011. Epub 2019 Nov 22.PMID: 31767131
Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations. Lin GW, Xu C, Chen K, Huang HQ, Chen J, Song B, Chan JKC, Li W, Liu W, Shih LY, Chuang WY, Kim WS, Tan W, Peng RJ, Laurensia Y, Cheah DMZ, Huang D, Cheng CL, Su YJ, Tan SY, Ng SB, Tang TPL, Han K, Wang VY, Jia WH, Pei Z, Li YJ, Gao S, Shi Y, Hu Z, Zhang F, Zhang B, Zeng YX, Shen H, He L, Ong CK, Lim ST, Chanock S, Kwong YL, Lin D, Rothman N, Khor CC, Lan Q, Bei JX; International NKTCL Working Group.Lancet Oncol. 2020 Feb;21(2):306-316. doi: 10.1016/S1470-2045(19)30799-5. Epub 2019 Dec 23.PMID: 31879220
Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma. de Mel S, Rashid MBM, Zhang XY, Goh J, Lee CT, Poon LM, Chan EHL, Liu X, Chng WJ, Chee YL, Lee J, Yuen YC, Lim JQ, Chia BKH, Laurensia Y, Huang D, Pang WL, Cheah DMZ, Wong EKY, Ong CK, Tang T, Lim ST, Ng SB, Tan SY, Loi HY, Tan LK, Chow EK, Jeyasekharan AD.Blood Cancer J. 2020 Jan 27;10(1):9. doi: 10.1038/s41408-020-0276-7.PMID: 31988286
Neurology
How to support the quality of life of people living with cognitive disorders? A (k)new challenge in the post-Covid World. Chen Y, Chen C.Eur J Neurol. 2020 Jun 3. doi: 10.1111/ene.14373. Online ahead of print.PMID: 32492256
Paediatrics
Single Hepatitis B Booster Dose in High-risk Children with Suboptimal Surface Antigen Antibody Responses After 3-dose Primary Vaccine Series. Low JM, Lee LY, Tan MLN, Hong M, Chan SM.Indian Pediatr. 2020 Jan 15;57(1):68-69.PMID: 31937704
Epicutaneous sensitization to food allergens in atopic dermatitis: What do we know? Tham EH, Rajakulendran M, Lee BW, Van Bever HPS.Pediatr Allergy Immunol. 2020 Jan;31(1):7-18. doi: 10.1111/pai.13127. Epub 2019 Oct 9.PMID: 31541586
Timeliness of Childhood Vaccination Coverage: the Growing Up in Singapore Towards Healthy Outcomes Study. Loy SL, Cheung YB, Chan JKY, Soh SE, Godfrey KM, Tan KH, Shek LP, Chong YS, Lek N, Yap F, Teoh OH, Yung CF, Thoon KC. Prev Sci. 2020 Apr;21(3):283-292. doi: 10.1007/s11121-019-01078-2. PMID: 31960261
Developmental Origins of Health and Disease: Impact of environmental dust exposure in modulating microbiome and its association with non-communicable diseases. Ooi DS, Tan CP, Tay MJ, Ong SG, Tham EH, Siah KTH, Eriksson JG, Godfrey KM, Shek LP, Loo EX.J Dev Orig Health Dis. 2020 Jun 15:1-12. doi: 10.1017/S2040174420000549. Online ahead of print.PMID: 32536356
Gut microbiota changes in children with autism spectrum disorder: a systematic review. Ho LKH, Tong VJW, Syn N, Nagarajan N, Tham EH, Tay SK, Shorey S, Tambyah PA, Law ECN.Gut Pathog. 2020 Feb 3;12:6. doi: 10.1186/s13099-020-0346-1. eCollection 2020.PMID: 32025243
Association between maternal carotenoid, vitamin A, and vitamin E levels and allergic outcomes in the offspring in the first 5 years of life. Loo EXL, Zhu Y, Lai JS, Chan YH, Ong CN, Tham EH, Goh A, Teoh OH, Tan KH, Yap F, Chong YS, Gluckman PD, Godfrey KM, Van Bever H, Lee BW, Chong MF, Shek LP.Pediatr Allergy Immunol. 2020 Jan;31(1):95-97. doi: 10.1111/pai.13122. Epub 2019 Oct 9.PMID: 31532016
Intentional Poisoning in Pediatric Patients: Examining the Risk Factors. Tay EY, Tan GF, Yeo AWC, Tham EH.Pediatr Emerg Care. 2020 Apr 16. doi: 10.1097/PEC.0000000000002101. Online ahead of print.PMID: 32304525
Mitigation of a Prospective Association Between Early Language Delay at Toddlerhood and ADHD Among Bilingual Preschoolers: Evidence from the GUSTO Cohort. Goh SKY, Yang H, Tsotsi S, Qiu A, Chong YS, Tan KH, Pei-Chi LS, Broekman BFP, Rifkin-Graboi A. J Abnorm Child Psychol. 2020 Apr;48(4):511-523. doi: 10.1007/s10802-019-00607-5. PMID: 31900836
Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia. Zhang C, Amanda S, Wang C, Tan TK, Ali MZ, Leong WZ, Ng LM, Kitajima S, Li Z, Yeoh AEJ, Tan SH, Sanda T.Haematologica. 2020 May 15:haematol.2019.245639. doi: 10.3324/haematol.2019.245639. Online ahead of print.PMID: 32414855
Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Rives S, Del Pozo Carlavilla M, Alonso MEV, Domínguez-Pinilla N, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch J, Pieters R, Brozou T, Borkhardt A, Escherich G, Lauten M, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Ottoffy G, Felice MS, Buldini B, Conter V, Stary J, Schrappe M.Eur J Cancer. 2020 Jun;132:11-16. doi: 10.1016/j.ejca.2020.03.021. Epub 2020 Apr 7.PMID: 32305831
Identifying IGH disease clones for MRD monitoring in childhood B-cell acute lymphoblastic leukemia using RNA-Seq. Li Z, Jiang N, Lim EH, Chin WHN, Lu Y, Chiew KH, Kham SKY, Yang W, Quah TC, Lin HP, Tan AM, Ariffin H, Yang JJ, Yeoh AE.Leukemia. 2020 Feb 25. doi: 10.1038/s41375-020-0774-4. Online ahead of print.PMID: 32099036
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity. Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ.Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5394-5401. doi: 10.1073/pnas.1915680117. Epub 2020 Feb 24.PMID: 32094176
Evaluation of a Quantitative Food Frequency Questionnaire for 5-Year-Old Children in an Asian Population. Sugianto R, Chan MJ, Wong SF, Shek LP, Tan KH, Chong YS, Godfrey KM, Tai BC, Chong MF. J Acad Nutr Diet. 2020 Mar;120(3):437-444. doi: 10.1016/j.jand.2019.09.021. Epub 2019 Dec 19. PMID: 31866358
Epidemiology
Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. Zheng Y, Huang T, Wang T, Mei Z, Sun Z, Zhang T, et al. Eur J Epidemiol. 2020 May 7. doi: 10.1007/s10654-020-00638-z. Online ahead of print. PMID: 32383070
Radiology and Diagnostic Imaging
Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies. Goh Y, Balasundaram G, Moothanchery M, Attia A, Li X, Lim HQ, Burton NC, Qiu Y, Putti TC, Chan CW, Iau P, Buhari SA, Hartman M, Tang SW, Ng CWQ, Chan YH, Pool FJ, Pillay P, Chua W, Kapur J, Jagmohan P, Sterling E, Quek ST, Olivo M.Transl Oncol. 2020 Feb;13(2):254-261. doi: 10.1016/j.tranon.2019.11.005. Epub 2019 Dec 21.PMID: 31869750
Operational Strategies to Prevent Coronavirus Disease 2019 (COVID-19) Spread in Radiology: Experience From a Singapore Radiology Department After Severe Acute Respiratory Syndrome. Goh Y, Chua W, Lee JKT, Ang BWL, Liang CR, Tan CA, Choong DAW, Hoon HX, Ong MKL, Quek ST.J Am Coll Radiol. 2020 Jun;17(6):717-723. doi: 10.1016/j.jacr.2020.03.027. Epub 2020 Apr 3.PMID: 32298643
Optoacoustic characterization of breast conserving surgery specimens – A pilot study. Balasundaram G, Goh Y, Moothanchery M, Attia A, Lim HQ, Burton NC, Qiu Y, Putti TC, Chan CW, Hartmann M, Quek ST, Olivo M.Photoacoustics. 2020 Apr 27;19:100164. doi: 10.1016/j.pacs.2020.100164. eCollection 2020 Sep.PMID: 32420026
Malignant phyllodes tumor of the male breast. Jagmohan P, Almaskeen HSH, Pillay PG, Goh Y, Singh P, Tay LE, Putti TC, Quek ST.Breast J. 2020 May;26(5):1050-1051. doi: 10.1111/tbj.13710. Epub 2019 Dec 26.PMID: 31876033
Immunology
Predictive Biomarkers of Immune Checkpoint Inhibition in Gastroesophageal Cancers. Sundar R, Smyth EC, Peng S, Yeong JPS, Tan P.Front Oncol. 2020 May 15;10:763. doi: 10.3389/fonc.2020.00763. eCollection 2020.PMID: 32500029
LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages. Lim SG, Suk K, Lee WH. J Immunol. 2020 Mar 1;204(5):1299-1309. doi: 10.4049/jimmunol.1900551. Epub 2020 Jan 24. PMID: 31980577
Research Methodology & Techniques
Handling ties in continuous outcomes for confounder adjustment with rank-ordered logit and its application to ordinal outcomes. Ning Y, Tan CS, Maraki A, Ho PJ, Hodgins S, Comasco E, Nilsson KW, Wagner P, Khoo EY, Tai ES, Kao SL, Hartman M, Reilly M, Støer NC.Stat Methods Med Res. 2020 Feb;29(2):437-454. doi: 10.1177/0962280219837656. Epub 2019 Apr 3.PMID: 30943882
Transcript expression-aware annotation improves rare variant interpretation. Cummings BB, Karczewski KJ, Kosmicki JA, Seaby EG, Watts NA, Singer-Berk M, Mudge JM, Karjalainen J, Satterstrom FK, O’Donnell-Luria AH, Poterba T, Seed C, Solomonson M, Alföldi J; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Daly MJ, MacArthur DG.Nature. 2020 May;581(7809):452-458. doi: 10.1038/s41586-020-2329-2. Epub 2020 May 27.PMID: 32461655
Robust estimation of the effect of an exposure on the change in a continuous outcome. Ning Y, Støer NC, Ho PJ, Kao SL, Ngiam KY, Khoo EYH, Lee SC, Tai ES, Hartman M, Reilly M, Tan CS.BMC Med Res Methodol. 2020 Jun 6;20(1):145. doi: 10.1186/s12874-020-01027-6.PMID: 32505178
Shared reference materials harmonize lipidomics across MS-based detection platforms and laboratories. Triebl A, Burla B, Selvalatchmanan J, Oh J, Tan SH, Chan MY, Mellet NA, Meikle PJ, Torta F, Wenk MR. J Lipid Res. 2020 Jan;61(1):105-115. doi: 10.1194/jlr.D119000393. Epub 2019 Nov 15. PMID: 31732502
NanoVar: accurate characterization of patients’ genomic structural variants using low-depth nanopore sequencing. Tham CY, Tirado-Magallanes R, Goh Y, Fullwood MJ, Koh BTH, Wang W, Ng CH, Chng WJ, Thiery A, Tenen DG, Benoukraf T. Genome Biol. 2020 Mar 3;21(1):56. doi: 10.1186/s13059-020-01968-7. PMID: 32127024
High-speed automatic characterization of rare events in flow cytometric data. Qi Y, Fang Y, Sinclair DR, Guo S, Alberich-Jorda M, Lu J, Tenen DG, Kharas MG, Pyne S.PLoS One. 2020 Feb 11;15(2):e0228651. doi: 10.1371/journal.pone.0228651. eCollection 2020.PMID: 32045462
Emergency Medicine
Safe patient transport for COVID-19. Liew MF, Siow WT, Yau YW, See KC.Crit Care. 2020 Mar 18;24(1):94. doi: 10.1186/s13054-020-2828-4.PMID: 32183864
Responding to COVID-19: how an academic infectious diseases division mobilized in Singapore. Archuleta S, Cross G, Somani J, Lum L, Santosa A, Alagha RA, Allen DM, Ang A, Beh D, Chai L, Chan SM, Lim SM, Olszyna DP, Ong C, Oon J, Salada BMA, Smitasin N, Sun L, Tambyah PA, Tham SM, Yan G, Yee CH, Dan YY, Jureen R, Tee N, Mahadevan M, Yau YW, Quek SC, Liu EH, Sin C, Bagdasarian N, Fisher DA.Version 2. BMC Med. 2020 Jun 8;18(1):179. doi: 10.1186/s12916-020-01641-7.PMID: 32507112
Healthcare
Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies. Goh Y, Balasundaram G, Moothanchery M, Attia A, Li X, Lim HQ, Burton NC, Qiu Y, Putti TC, Chan CW, Iau P, Buhari SA, Hartman M, Tang SW, Ng CWQ, Chan YH, Pool FJ, Pillay P, Chua W, Kapur J, Jagmohan P, Sterling E, Quek ST, Olivo M.Transl Oncol. 2020 Feb;13(2):254-261. doi: 10.1016/j.tranon.2019.11.005. Epub 2019 Dec 21.PMID: 31869750
Psychological Impact of the COVID-19 Pandemic on Health Care Workers in Singapore. Tan BYQ, Chew NWS, Lee GKH, Jing M, Goh Y, Yeo LLL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ying Ng AY, Teoh HL, Ho CS, Ho RC, Sharma VK.Ann Intern Med. 2020 Apr 6:M20-1083. doi: 10.7326/M20-1083. Online ahead of print.PMID: 32251513
Doctors and social media: knowledge gaps and unsafe practices. Low JM, Tan MY, Joseph R.Singapore Med J. 2020 Apr 21. doi: 10.11622/smedj.2020067. Online ahead of print.PMID: 32312027
The global impact of COVID-19 on vascular surgical services. Ng JJ, Ho P, Dharmaraj RB, Wong JCL, Choong AMTL.J Vasc Surg. 2020 Jun;71(6):2182-2183.e1. doi: 10.1016/j.jvs.2020.03.024. Epub 2020 Apr 1.PMID: 32247029
Cessation of cancer screening: An unseen cost of the COVID-19 pandemic? Tan KK, Lau J.Eur J Surg Oncol. 2020 May 11:S0748-7983(20)30457-1. doi: 10.1016/j.ejso.2020.05.004. Online ahead of print.PMID: 32409112
Continuing chronic disease care during COVID-19 and beyond. Hong WZ, Chan GC, Chua HR.J Am Med Dir Assoc. 2020 May 16. doi: 10.1016/j.jamda.2020.05.013. Online ahead of print.PMID: 32425700
A segregated-team model to maintain cancer care during the COVID-19 outbreak at an academic center in Singapore. Ngoi N, Lim J, Ow S, Jen WY, Lee M, Teo W, et al. Ann Oncol. 2020 Mar 31. pii: S0923-7534(20)36410-3. doi: 10.1016/j.annonc.2020.03.306. [Epub ahead of print]. PMID: 32243893
Responding to COVID-19: how an academic infectious diseases division mobilized in Singapore. Archuleta S, Cross G, Somani J, Lum L, Santosa A, Alagha RA, Allen DM, Ang A, Beh D, Chai L, Chan SM, Lim SM, Olszyna DP, Ong C, Oon J, Salada BMA, Smitasin N, Sun L, Tambyah PA, Tham SM, Yan G, Yee CH, Dan YY, Jureen R, Tee N, Mahadevan M, Yau YW, Quek SC, Liu EH, Sin C, Bagdasarian N, Fisher DA.Version 2. BMC Med. 2020 Jun 8;18(1):179. doi: 10.1186/s12916-020-01641-7.PMID: 32507112
Revisiting the dangers of the coronavirus in the ophthalmology practice. Seah I, Su X, Lingam G.Eye (Lond). 2020 Feb 6:1-3. doi: 10.1038/s41433-020-0790-7. Online ahead of print.PMID: 32029919
Prevention of nosocomial SARS-CoV-2 transmission in endoscopy: international recommendations and the need for a gold standard. Ong J, Cross GB, Dan YY. Gut. 2020 Apr 2. pii: gutjnl-2020-321154. doi: 10.1136/gutjnl-2020-321154. [Epub ahead of print] PMID: 32241901
Cost-effectiveness analysis of antiviral treatment for pregnant women with high viral load to prevent hepatitis B virus vertical transmission. Ma T, Lee LY, Aw MM, Lee GH.Singapore Med J. 2020 Jan;61(1):24-27. doi: 10.11622/smedj.2019092. Epub 2019 Aug 7.PMID: 31388686
Restructuring the surgical service during the COVID-19 pandemic: Experience from a tertiary institution in Singapore. Low TY, Hartman M, Chee CYJ, Mohankumar B, Ang SBL, San MT, Shabbir A, Madhavan K, So JBY.Am J Surg. 2020 May 14:S0002-9610(20)30278-6. doi: 10.1016/j.amjsurg.2020.05.021. Online ahead of print.PMID: 32418631
A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak. Chew NWS, Lee GKH, Tan BYQ, Jing M, Goh Y, Ngiam NJH, Yeo LLL, Ahmad A, Ahmed Khan F, Napolean Shanmugam G, Sharma AK, Komalkumar RN, Meenakshi PV, Shah K, Patel B, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ying Ng AY, Teoh HL, Tsivgoulis G, Ho CS, Ho RC, Sharma VK.Brain Behav Immun. 2020 Apr 21:S0889-1591(20)30523-7. doi: 10.1016/j.bbi.2020.04.049. Online ahead of print.PMID: 32330593
Basic & Translational Research
Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation. Nakamura-Ishizu A, Suda T.Ann N Y Acad Sci. 2020 Apr;1466(1):51-58. doi: 10.1111/nyas.14169. Epub 2019 Jul 10.PMID: 31292976
The effect of LRRK2 loss-of-function variants in humans. Whiffin N, Armean IM, Kleinman A, Marshall JL, Minikel EV, Goodrich JK, et al. Nat Med. 2020 May 27. doi: 10.1038/s41591-020-0893-5. Online ahead of print.PMID: 32461697
A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity. Endoh M, Baba M, Endoh T, Hirayama A, Nakamura-Ishizu A, Umemoto T, Hashimoto M, Nagashima K, Soga T, Lang M, Schmidt LS, Linehan WM, Suda T.Cell Rep. 2020 Feb 11;30(6):1823-1834.e5. doi: 10.1016/j.celrep.2020.01.042.PMID: 32049013
Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential. O’Neill A, Chin D, Tan D, Abdul Majeed AQBB, Nakamura-Ishizu A, Suda T.Haematologica. 2020 Jun 11:haematol.2019.241406. doi: 10.3324/haematol.2019.241406. Online ahead of print.PMID: 32527954
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. Numata A, Kwok HS, Zhou QL, Li J, Tirado-Magallanes R, Espinosa Angarcia V, Hannah RL, Park J, Wang CQ, Krishnan V, Rajagopalan D, Zhang Y, Zhou S, Welner R, Osato M, Jha S, Bohlander SK, Göttgens B, Yang H, Benoukraf T, Lough JW, Bararia D, Tenen DG.Blood. 2020 Jun 15:blood.2019001279. doi: 10.1182/blood.2019001279. Online ahead of print.PMID: 32542325