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This study, co-led by A/Prof Takaomi Sanda and A/Prof Allen Yeoh, delves into T-cell acute lymphoblastic leukemia (T-ALL), a difficult to treat form of blood cancer. In T-ALL, the mutated TAL1 gene switches on the enhMYCN, a gene regulatory signal which increases MYCN gene expression. T-ALL cells rely heavily on MYCN to grow. Targeting this pathway may offer a potential treatment approach for T-ALL.
Read more here: https://www.nature.com/articles/s41375-023-01993-y
Gastric cancer (GC) has significant global mortality with high heterogeneity. A study of 226 GC samples from 121 patients integrated …
The tumour microenvironment (TME) plays a pivotal role in cancer progression, metastasis, and therapeutic resistance. Comprised of diverse cells, extracellular …
Research led by N2CR member Dr. Cheok Chit Fang found that the tumour suppressor protein p53 protects DNA during replication …