This study, co-led by A/Prof Takaomi Sanda and A/Prof Allen Yeoh, delves into T-cell acute lymphoblastic leukemia (T-ALL), a difficult to treat form of blood cancer. In T-ALL, the mutated TAL1 gene switches on the enhMYCN, a gene regulatory signal which increases MYCN gene expression. T-ALL cells rely heavily on MYCN to grow. Targeting this pathway may offer a potential treatment approach for T-ALL.

Read more here: https://www.nature.com/articles/s41375-023-01993-y