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This study, co-led by A/Prof Takaomi Sanda and A/Prof Allen Yeoh, delves into T-cell acute lymphoblastic leukemia (T-ALL), a difficult to treat form of blood cancer. In T-ALL, the mutated TAL1 gene switches on the enhMYCN, a gene regulatory signal which increases MYCN gene expression. T-ALL cells rely heavily on MYCN to grow. Targeting this pathway may offer a potential treatment approach for T-ALL.
Read more here: https://www.nature.com/articles/s41375-023-01993-y
This research, led by N2CR members Prof Goh Boon Cher and Prof Shazib Pervaiz with Dr Jayshree Hirpara as the …
Detecting cancer-driving mutations is crucial for understanding cancer and developing treatments. Existing prediction tools vary in accuracy. N2CR member A/Prof …
Led by N2CR member A/Prof Polly Chen, this research highlights the crucial role of ‘death associated protein 3’ (DAP3) in …