Intestinal metaplasia (IM), often symptomless, poses a six-fold increased risk of stomach cancer. In this cross-institutional study, co-led by N2CR member Prof Jimmy So, researchers have identified 26 IM driver genes pivotal in the transition to cancer. The findings, published in Cancer Cell, was the world’s largest genomic survey of over 1,100 samples of IM. This significant discovery offers insight into the processes that control the transformation to stomach cancer, providing a crucial opportunity for early detection and focused prevention.

Read more: https://pubmed.ncbi.nlm.nih.gov/37890493/