5-Fluorouracil (5-FU) is a common chemotherapy drug widely used around the world to treat cancer but development of resistance which compromises responsiveness remains a major hurdle to its efficacy. A team of researchers, led by N2CR member A/Prof Chen Ee Sin, explores the reasons behind the resistance of certain cancer cells to 5-FU. By studying fission yeast mutants, the researchers identified specific mutations that influence the cells’ resistance to 5-FU. They also discovered that Ino80 complex proteins play a significant role in 5-FU resistance and could be targeted to reverse this resistance. The study’s practical implications include providing insights into drug resistance mechanisms for 5-FU, a widely used chemotherapy drug. These findings may lead to the development of new strategies for managing drug resistance in cancer treatment, although further research on human cells is required for validation.

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