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In this study, led by A/Prof Polly Chen, multi-omics approaches revealed that MDA5 loss in ADAR1-deficient livers does not reduce inflammation and dysfunction. Hepatocyte-macrophage interaction via the PGRN-EGFR axis controls responses to endogenous duplex RNAs, with PGRN driving interferon responses and macrophage recruitment. ADAR1 suppresses PGRN-EGFR signalling, helping tumours evade the immune system.
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Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow, leading to the buildup …
Muscle is our first line of defence against cancer. A randomised clinical trial in Singapore, led by N2CR members A/Prof …
Nasopharyngeal carcinoma (NPC) is common in South China and parts of Southeast Asia. Despite treatment, 20-30% of patients relapse within …