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In this study, led by A/Prof Polly Chen, multi-omics approaches revealed that MDA5 loss in ADAR1-deficient livers does not reduce inflammation and dysfunction. Hepatocyte-macrophage interaction via the PGRN-EGFR axis controls responses to endogenous duplex RNAs, with PGRN driving interferon responses and macrophage recruitment. ADAR1 suppresses PGRN-EGFR signalling, helping tumours evade the immune system.
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This research, led by N2CR members Prof Goh Boon Cher and Prof Shazib Pervaiz with Dr Jayshree Hirpara as the …
Detecting cancer-driving mutations is crucial for understanding cancer and developing treatments. Existing prediction tools vary in accuracy. N2CR member A/Prof …
Led by N2CR member A/Prof Polly Chen, this research highlights the crucial role of ‘death associated protein 3’ (DAP3) in …