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In this study, led by A/Prof Polly Chen, multi-omics approaches revealed that MDA5 loss in ADAR1-deficient livers does not reduce inflammation and dysfunction. Hepatocyte-macrophage interaction via the PGRN-EGFR axis controls responses to endogenous duplex RNAs, with PGRN driving interferon responses and macrophage recruitment. ADAR1 suppresses PGRN-EGFR signalling, helping tumours evade the immune system.
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Gastric cancer (GC) has significant global mortality with high heterogeneity. A study of 226 GC samples from 121 patients integrated …
The tumour microenvironment (TME) plays a pivotal role in cancer progression, metastasis, and therapeutic resistance. Comprised of diverse cells, extracellular …
Research led by N2CR member Dr. Cheok Chit Fang found that the tumour suppressor protein p53 protects DNA during replication …