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In this study, led by A/Prof Polly Chen, multi-omics approaches revealed that MDA5 loss in ADAR1-deficient livers does not reduce inflammation and dysfunction. Hepatocyte-macrophage interaction via the PGRN-EGFR axis controls responses to endogenous duplex RNAs, with PGRN driving interferon responses and macrophage recruitment. ADAR1 suppresses PGRN-EGFR signalling, helping tumours evade the immune system.
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CIITA is the master regulator of MHC class-II immune genes that are important for defense mechanism against infections and cancer …
Chemotherapy, although the first line of defense in cancer treatment, is indiscriminate and is damaging to the entire body, which, …
This research, led by N2CR members Prof Goh Boon Cher and Prof Shazib Pervaiz with Dr Jayshree Hirpara as the …