This study co-led by N2CR member A/Prof Gautam Sethi, investigates the effects of CHL-C (an imidazopyridine-tethered chalcone) on colorectal cancer (CRC). CHL-C was shown to induce apoptosis and autophagy in CRC cell lines by down-regulating key components of the Wnt/β-catenin signaling pathway. The compound also demonstrated strong binding affinity to β-catenin, comparable to known inhibitors. In vivo experiments further confirmed that CHL-C significantly inhibited tumor growth and activated cell death mechanisms, suggesting its potential as a therapeutic agent for CRC.

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