The accurate diagnosis of the most common small B-cell lymphoma histological subtypes can pose a significant challenge for pathologists. There is an urgent need to address this challenge as the enhancement of diagnostic accuracy can lead to improved treatments and clinical outcome. In this study led by A/Prof Tan Soo Yong, the authors explored if microRNA (miRNA) expression can serve as potential biomarkers to improve diagnostic accuracy. Through their investigation, the authors identified and verified two sets of microRNAs that could not only identify small B-cell lymphomas but also distinguish between four subtypes of such lymphomas, highlighting the promise of utilising miRNA expression profiling as an aid for the diagnosis of small B-cell lymphomas.

Read more: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856483/